Rudresh Kumar

Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

OBJECTIVEnTo screen different analogues of mangiferin pharmacologically for antipyretic activity.nnnMETHODSnThe naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the ethanolic extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin, 5-(N-p-chlorophenylamino methyleno) mangiferin, 5-(N-2-methyl phenylamino methyleno) mangiferin, 5-(N-p-methoxy phenylamino methyleno) mangiferin, 5-(N, N-diphenylamino methyleno) mangiferin, 5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues. The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 mg/kg. Mangiferin and its analogues were characterized by melting point andR(f)value determination and through spectral technique like UV, IR, and NMR spectral analysis.nnnRESULTSnThe antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie. 200 mg/kg which was depicted through a decrease in rectal temperature up to 3 h.nnnCONCLUSIONSnThe antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-α and anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.

Investigation of crystalline and electronic band alignment properties of GaP/Ge(111) heterostructure

Gallium phosphide (GaP) epitaxial layer and nanostructures are grown on n-Ge(111) substrates using metal organic vapour phase epitaxy. It is confirmed by high resolution x-ray diffraction measurements that the layer is highly crystalline and oriented with the coexistence of two domains, i.e., GaP(111)A and GaP(111)B, with an angle of 60° between them due to the formation of a wurtzite monolayer at the interface. The valence band offset between GaP and Ge is 0.7u2009±u20090.1u2009eV as determined from the valence band onsets and from Krauts method. A band alignment diagram for GaP/Ge/GeOx is also constructed which can be used to design monolithic optoelectronic integrated circuits.

Quality evaluation of mutton nuggets incorporated with optimized level of flaxseed flour

Purpose n n n n nFlaxseed is considered as a source of functional ingredients because it contains alpha-linolenic acid and high amount of dietary fiber which provides potential health benefits. Therefore, this paper aims to evaluate the effect of flaxseed flour on the quality of mutton nuggets. n n n n nDesign/methodology/approach n n n n nMutton nuggets were incorporated with three different levels of hydrated flaxseed flour (1:1), namely, 4, 8 and 12 per cent to optimize the level of incorporation. Detailed profile analysis was carried out to study various physico-chemical parameters, texture profile analysis and color values in the product with optimum level and compared with control product. n n n n nFindings n n n n nThere was no significant difference (p > 0.05) in sensory attributes of product with 4 and 8 per cent level of incorporation except for binding; however, significantly lower (p < 0.01) scores were observed for 12 per cent incorporation level. On the basis of sensory scores, 8 per cent level of incorporation was adjudged as optimum. Incorporation of flaxseed flour resulted in significantly lower (p < 0.01) moisture content, but higher (p < 0.01) fat and dietary fiber content. Texture profile analysis showed increased hardness of the product but resulted in decreased springiness and chewiness parameters. Incorporation of flaxseed flour significantly increased (p < 0.01) redness and yellowness of the product which improved overall acceptability. n n n n nOriginality/value n n n n nThe research work is original.

Monolithic composite based on multilayered fabrics for W-band radar absorber

In this paper a monolithic radar absorbing composite based on the fabric based multilayer laminates have been designed and fabricated. The multilayer laminate consists of the glass and carbon based fabrics along with lossy dielectric fillers in the epoxy medium. The individual laminates have been fabricated using vaccum bagging technology and their constitutive electromagnetic properties e.g. dielectric constant and loss tangent have been evaluated using the quasi optical free space measurement system (QOFMS) in the W band (75–110 GHz) frequency region. Based on the simulated results, optimized monolithic configuration of individual laminates have been fabricated and tested for the electromagnetic absorption using QOFMS. The experimental result shows minimum 10 dB reflection loss (90% electromagnetic absorption) across the entire frequency region. The fabricated structure shows potential applications for the radar cross section reduction for the stealth applications.