Ruei-Hao Shie

Burden of disease attributable to ambient fine particulate matter exposure in Taiwan

BACKGROUND/PURPOSE There is compelling epidemiological evidence that links air pollution to increased risk of mortality from cardiopulmonary disease and lung cancer. We quantified the burden of mortality attributable to ambient fine particulate matter (PM2.5) among the Taiwanese population in 2014 at the national and subnational levels. METHODS Subnational PM2.5 exposure levels were obtained from Taiwan Air Quality Monitoring Network. Relative risks were derived from a previously developed exposure-response model. Population attributable fraction for cause-specific mortality was estimated at the county level using the estimated ambient PM2.5 concentrations and the relative risk functions. RESULTS In 2014, PM2.5 accounted for 6282 deaths [95% confidence interval (CI), 5716-6847], from ischemic heart disease (2244 deaths; 95% CI, 2015-2473), stroke (2140 deaths; 95% CI, 1760-2520), lung cancer (1252 deaths; 95% CI, 995-1509), and chronic obstructive pulmonary disease (645 deaths; 95% CI, 418-872). Nationally, the population attributable mortality fraction of PM2.5 for the four disease causes was 18.6% (95% CI, 16.9-20.3%). Substantial geographic variation in PM2.5 attributable mortality fraction was found; the percentage of deaths attributable to PM2.5 ranged from 8.7% in Hualian County to 21.8% in Yunlin County. In terms of absolute number of deaths, New Taipei and Kaohsiung cities had the largest number of deaths associated with PM2.5 (874 and 829 deaths, respectively) among all cities and counties. CONCLUSION Ambient PM2.5 pollution is a major mortality risk factor in Taiwan. Aggressive and multisectorial intervention strategies are urgently needed to bring down the impact of air pollution on environment and health.

Urinary levels of 1-hydroxypyrene in children residing near a coal-fired power plant

BACKGROUND The effects of emissions from coal-fired power plants on childrens exposure to polycyclic aromatic hydrocarbons (PAHs) are not well understood. OBJECTIVES This study aimed to evaluate the sources and the urinary levels of 1-hydroxypyrene, a biomarker of exposure to PAHs, among children living in proximity to a coal-fired power plant. METHODS Study areas consisted of two high exposure and two low exposure communities, at different distances and directions from a large coal-fired power plant in central Taiwan. Study subjects included 369 children aged 1-13 years and randomly selected from each community. Each childs urinary 1-hydroxypyrene concentration was measured by a high-performance liquid chromatography-fluorescence detector method. Samples of ambient air were analyzed for PAHs using a gas chromatography-mass spectrometry method. Information on important factors was collected by an interview using a structured questionnaire. Multiple regression analysis was used to assess factors significantly associated with urinary 1-hydroxypyrene levels. RESULTS Levels of PAHs in ambient air in the high exposure communities were higher than those in the low exposure communities. Children living in high exposure communities had higher mean urinary 1-hydroxypyrene concentrations than those in low exposure communities (0.186 and 0.194 vs. 0.113 and 0.122 μmol/mol-creatinine, respectively). The difference in urinary 1-hydroxypyrene levels between the high exposure communities and one low exposure community remained significant after adjusting for age, gender, environmental tobacco smoke, dietary exposure, and traffic. CONCLUSIONS Children living in communities downwind of and in proximity to the coal-fired power plant had significantly increased urinary 1-hydroxypyrene levels.

Tracking hazardous air pollutants from a refinery fire by applying on-line and off-line air monitoring and back trajectory modeling

The air monitors used by most regulatory authorities are designed to track the daily emissions of conventional pollutants and are not well suited for measuring hazardous air pollutants that are released from accidents such as refinery fires. By applying a wide variety of air-monitoring systems, including on-line Fourier transform infrared spectroscopy, gas chromatography with a flame ionization detector, and off-line gas chromatography-mass spectrometry for measuring hazardous air pollutants during and after a fire at a petrochemical complex in central Taiwan on May 12, 2011, we were able to detect significantly higher levels of combustion-related gaseous and particulate pollutants, refinery-related hydrocarbons, and chlorinated hydrocarbons, such as 1,2-dichloroethane, vinyl chloride monomer, and dichloromethane, inside the complex and 10 km downwind from the fire than those measured during the normal operation periods. Both back trajectories and dispersion models further confirmed that high levels of hazardous air pollutants in the neighboring communities were carried by air mass flown from the 22 plants that were shut down by the fire. This study demonstrates that hazardous air pollutants from industrial accidents can successfully be identified and traced back to their emission sources by applying a timely and comprehensive air-monitoring campaign and back trajectory air flow models.

Exposure to volatile organic compounds and kidney dysfunction in thin film transistor liquid crystal display (TFT-LCD) workers

Many volatile organic compounds (VOCs) are emitted during the manufacturing of thin film transistor liquid crystal displays (TFT-LCDs), exposure to some of which has been reported to be associated with kidney dysfunction, but whether such an effect exists in TFT-LCD industry workers is unknown. This cross-sectional study aimed to investigate the association between exposure to VOCs and kidney dysfunction among TFT-LCD workers. The results showed that ethanol (1811.0+/-1740.4 ppb), acetone (669.0+/-561.0 ppb), isopropyl alcohol (187.0+/-205.3 ppb) and propylene glycol monomethyl ether acetate (PGMEA) (102.9+/-102.0 ppb) were the four dominant VOCs present in the workplace. The 63 array workers studied had a risk of kidney dysfunction 3.21-fold and 3.84-fold that of 61 cell workers and 18 module workers, respectively. Workers cumulatively exposed to a total level of isopropyl alcohol, PGMEA and propylene glycol monomethyl ether> or =324 ppb-year had a significantly higher risk of kidney dysfunction (adjusted OR=3.41, 95% CI=1.14-10.17) compared with those exposed to <25 ppb-year after adjustment for potential confounding factors. These findings indicated that array workers might be the group at greatest risk of kidney dysfunction within the TFT-LCD industry, and cumulative exposure to specific VOCs might be associated with kidney dysfunction.

The distance-to-source trend in vanadium and arsenic exposures for residents living near a petrochemical complex.

Biological monitoring of vanadium (V) and arsenic (As) for residents living near a big petrochemical complex has not been previously studied. This study aims to investigate distance-to-source trends in urinary levels and dispersion-estimated concentrations of V and As in areas surrounding a petrochemical complex in central Taiwan. Our study subjects were 1424 residents living in the townships up to ~40 km from the petrochemical complex, and categorized as near (Zone A), further (Zone B) and furthest (Zone C) from the complex. Urinary and ambient V and As levels were analyzed by inductively coupled plasma mass spectrometry. Two-stage dispersion model was used to estimate V and As concentrations at each study subject’s address. Multiple linear regression models were used to study the effects of distance-to-source and estimated air concentrations of V and As on the urinary V and As levels of study subjects. Area-wide levels of both V and As showed a high-to-low trend in urinary levels (μg/g-creatinine) from Zone A (V with 2.86±2.30 and As with 104.6±147.9) to Zone C (V with 0.73±0.72 and As with 73.8±90.8). For study subjects, urinary V and As levels were decreased by 0.09 and 1.17 μg/g-creatinine, respectively, with 1 km away from the emission source of the petrochemical complex, and urinary V levels were significantly elevated by 0.38 μg/g-creatinine with a 1 ng/m3 increase in estimated ambient V concentrations at their addresses. Our study concludes a distance-to-source gradient in V and As exposures exists for residents living near a petrochemical complex with oil refineries and coal-fired power plants and two-stage dispersion model can predict such a trend for V when inhalation is the major exposure route, but not for As that exposure may be from multiple sources and exposure routes.

Using pollution roses to assess sulfur dioxide impacts in a township downwind of a petrochemical complex

This study used pollution roses to assess sulfur dioxide (SO2) pollution in a township downwind of a large petrochemical complex based on data collected from a single air quality monitoring station. The pollution roses summarized hourly SO2 concentrations at the Taishi air quality monitoring station, located approximately 7.8–13.0 km south of the No. 6 Naphtha Cracking Complex in Taiwan, according to 36 sectors of wind direction during the preoperational period (1995–1999) and two postoperational periods (2000–2004 and 2005–2009). The 99th percentile of hourly SO2 concentrations 350˚ downwind from the complex increased from 28.9 ppb in the preoperational period to 86.2–324.2 ppb in the two postoperational periods. Downwind SO2 concentrations were particularly high during 2005–2009 at wind speeds of 6–8 m/sec. Hourly SO2 levels exceeded the U.S. Environmental Protection Agency (EPA) health-based standard of 75 ppb only in the postoperational periods, with 65 exceedances from 0–10˚ and 330–350˚ downwind directions during 2001–2009. This study concluded that pollution roses based on a single monitoring station can be used to investigate source contributions to air pollution surrounding industrial complexes, and that it is useful to combine such directional methods with analyses of how pollution varies between different wind speeds, times of day, and periods of industrial development. Implications: The pollution roses summarize SO2 concentrations by wind direction and to investigate source contribution to air quality. Percentile statistics can catch pollution episodes occurring in a very short time at specific wind directions and speeds. The downwind areas have already exceeded regulated 1-hr SO2 standard since the operation of the complex.

Characterization of volatile organic compounds in the vicinity of an optoelectronics industrial park in Taiwan.

Abstract This study aimed to determine the concentration of volatile organic compounds (VOCs) and investigate the impacts of traffic and industrial activities on the concentration of VOCs near the Central Taiwan Science Park (CTSP) in Taiwan during 2005. Twelve-hour canister sampling was performed at 10 sites near CTSP every season. Samples were analyzed by gas chromatography with a mass-selective detector. The traffic flow rate, industrial production rates, and meteorological information were also collected to assess their impacts on VOC concentrations using multiple linear regression models. The major components determined in the atmosphere were toluene (29.4–218.8 μg m−3), acetone (30–71.3 μg m−3), m/p-xylene (7.8–51.7 μg m−3), and ethanol (16.4–47.8 μg m−3); only ethanol revealed a pattern of increasing concentration from spring to winter. The log-transformed mean concentrations of toluene, acetone, and ethanol were significantly associated with the production rates of the optoelectronic companies after adjustment for traffic flow and meteorological factors (P < 0.05). There was no significant association between the total traffic flow rate and any log-transformed mean concentrations of VOCs. Each

Assessment of urinary thiodiglycolic acid exposure in school-aged children in the vicinity of a petrochemical complex in central Taiwan

1 million (U.S.) increase in optoelectronic sales was significantly associated with increasing mean concentrations of 1.29 ±1.08 μg m-3 for toluene, 1.13 ±1.05μg m-3 for acetone, and 1.25± 1.09μg m-3 for ethanol. The authors’ findings suggest that optoelectronic industrial activities are still the predominant source for VOC emissions surrounding this industrial park.

Increased cancers among residents living in the neighborhood of a petrochemical complex: A 12-year retrospective cohort study

BACKGROUND School-aged children living in the vicinity of vinyl chloride (VCM)/polyvinyl chloride (PVC) factories may have an increased risk of exposure to hazardous air pollutants. OBJECTIVES We aimed to evaluate the urinary thiodiglycolic acid (TDGA) level, as TDGA is a major metabolite of VCM, for students at elementary schools near a petrochemical complex in central Taiwan. METHODS We recruited 343 students from 5 elementary schools based on distance to the VCM/PVC factory. First-morning urine and blood samples were obtained from our subjects from October 2013 to September 2014. Urine samples were analyzed for urinary creatinine and TDGA using LC/MS-MS. Hepatitis virus infection were assessed using blood samples. We determined their vitamin consumption, resident location, parents employment, and other demographic or lifestyle characteristics using a questionnaire. RESULTS Median urinary TDGA levels for 316 students at 5 elementary schools from the closest (<.9km) to the farthest (∼8.6km) with respect to the petrochemical complex were 147.6, 95.5, 115.5, 86.8, and 17.3μg/g creatinine, respectively. After adjusting for age, gender, hepatitis virus infection, vitamin B consumption, passive smoking, and home to source distance, we found that urinary TDGA levels for the closest students was significantly higher than those at other schools. Further, median urinary TDGA levels for students during school time were 4.1-fold higher than those during summer vacation. CONCLUSIONS After adjusting for confounders, urinary TDGA levels for the school-aged children decreased with increasing distances between the elementary schools and the petrochemical complex.

Dynamic real‐time monitoring of chloroform in an indoor swimming pool air using open‐path Fourier transform infrared spectroscopy

This study investigates whether cancers are increased for residents living in the vicinity of a petrochemical complex with coal power plants and refineries. We recruited a residential cohort of 2388 long-term residents aged above 35 years in 2009-2012 who lived within a 40 km radius of the complex. We measured their internal exposure biomarkers of urinary carcinogenic metals and retrospectively compared cancer incidences between those who lived fewer than 10 km from the complex (high exposure, HE) and those who lived more than 10 km from the complex (low exposure, LE). Residents had lived in their respective areas for 12 years, since the complex began operating in mid-1999. This included two periods of operation: 0-9 years and 10-12 years. Crude cumulative incident rates (CIRs) of all cancers were calculated for new cancer cases (ICD-9: 140-165, 170-176, 179-208) recorded in the Taiwan Health Insurance Database over total person-years at risk in each study period. Poisson regression was applied to estimate relative risks for the CIRs of all cancers between HE and LE areas during the 10-12 years since the beginning of the complexs operation, adjusting for age, gender, body mass index, smoking, hepatitis C, and occupational exposure. We found that our study subjects in HE areas had higher urinary carcinogenic metal levels, including As, Cd, Hg, Pb, and V, and higher prevalence rates of hepatitis C than those in LE areas. After the complex had been operating for 10-12 years, SIRs per 1000 person-years for all cancers in HE and LE areas were 4.44 vs. 2.48 for all subjects, 15.2 vs. 4.86 for elder subjects aged above 60 years, and 2.94 vs. 2.71 for female subjects. Correspondingly, the adjusted relative risks of CIRs for all cancers between HE and LE areas were 1.29 (95% CI: 0.99-1.68) for all subjects, 1.52 (1.04-2.22) for elder subjects, 1.41 (1.00-1.97) for female subjects, and 1.91 (1.15-3.19) for female elderly subjects. We conclude that elder and female residents living within 10 km of a petrochemical complex had higher carcinogenic exposure and cancers than those living farther away from the complex after the complex had been operating for 10 years.