Rulon W. Rawson

The effects of chemical derivatives of thyroid-stimulating hormone on the metamorphosis of Rana pipiens tadpoles☆

Abstract Thirty-nine different chemically modified derivatives of TSH preparations have been studied on metamorphosis of Rana pipiens tadpoles. The results indicate that derivatives prepared under a wide range of conditions show various degrees of metamorphosing ability when tested in the tadpole. None of the derivatives gave evidence of inhibiting simultaneously administered TSH, or preventing normal metamorphosis.