Rumana Akhter

Comparative In Vitro Equivalence Evaluation of Some Loratadine Generic Tablets Marketed in Bangladesh

Loratadine is a potent, rapidly effective and long-acting non-sedative, histamine H1 receptor antagonist, with anti-allergic properties. The purpose of this research work was to evaluate the pharmaceutical equivalent of six different brands of loratadine 10 mg tablets using various pharmacopoeial and nonpharmacopoeial tests with special landmark on in vitro dissolution study and with different price ranges purchased from retail pharmacies of Bangladesh. All brands complied with the official specification for friability, uniformity of weight and disintegration time but four brands did not comply with the official specification for hardness. Assay of loratadine tablets revealed that all samples contained 86.65-95.02% of labeled potency. Drug release was satisfactory for all brands, since more than 96.76% of the loratadine was dissolved in the medium within an hour of the test. The dissolution profiles were compared with the use of model independent approaches of difference factor and similarity factor, showing that all brands are similar with brand L3 and can be used interchangeably.

Evaluation of In vitro Antioxidant and In vivo Pharmacological Activity of Leaf Extracts of Hoya parasitica (Wall.)

In present study, leaf extract of Hoya parasitica Wall. was evaluated for in vitro antioxidant and membrane stabilizing activity along with in vivo gastro intestinal motility and acute toxicity. Five different assays were performed to evaluate antioxidant activity. In DPPH free radical scavenging activity, methanol, ethanol and chloroform extract exhibited IC50 value similar to standard ascorbic acid. The presence of flavonoid and phenolic contents was also similar in all the plant extracts. However, chloroform extract showed remarkable reducing power capacity (69.10% at 200µg/mL). In case of membrane stabilization, the chloroform extract showed maximum inhibition (32.62 %) of haemolysis, whereas the ethanol extract showed a significant (p