Rümeysa Sunal

1-(3-methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanones and ethanols: analgesic and antiinflammatory activities

Abstract Eight new 1-(3-methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanone and 1-(methyl-2-benzoxazolinone-6-yl)-2-(4-substituted piperazine-1-yl)ethanol derivatives were synthesized and their chemical structures elucidated by UV, IR, 1 H-NMR and elemental analysis. The analgesic activity of these compounds was investigated by a modified Koster test and constant temperature hot-plate test. Antiinflammatory activity of the compounds was screened by using the carrageenan hind-paw edema test. All the compounds showed higher analgesic activity than aspirin. Carrageenan edema inhibition of the compounds was higher than indomethacin. None of the compounds induced gastric ulceration.

Effect of Beta-Endorphin and Cold Stress on Heart Noradrenalin Levels in Rats

We investigated cardiac noradrenalin (NA) levels during stress (from cold and from swimming) and after i.p. administration of beta-endorphin. Cardiac NA levels were significantly increased by endorphin, 1.25 mg X kg-1, and decreased by 10 mg X kg-1. Beta-endorphin, 10 mg X kg-1, and cimetidine, 20 mg X kg-1, decreased cardiac NA to control levels in stressed animals. Naloxone given to stressed animals treated either with beta-endorphin or cimetidine elevated NA to control concentrations, but failed to restore NA to the elevated levels induced by stress. These results suggest endorphin involvement in enhanced NA levels in stress and a possible role of H2-receptors in this involvement.