Rummana Aslam

Guidelines for the treatment of pressure ulcers

1. Co-chaired this panel 2. University of Washington, Seattle, WA 3. University of Texas Medical Branch Galveston, Galveston, TX 4. Sinai Hospital, Baltimore, MD 5. Johns Hopkins Medical Institutions, Baltimore, MD 6. University of Southern Denmark, Odense University Hospital, Odense, Denmark 7. University of South Florida, Tampa, FL 8. University of Virginia Health System, Charlottesville, VA 9. St. Louis Medical Center, St. Louis, MO, and 10. University of San Francisco, San Francisco, CA

Guidelines for the treatment of venous ulcers

1. Co-chaired this panel2. University of South Florida, Tampa, FL3. Healthpoint Ltd., Fort Worth, TX4. University of California, San Francisco, CA5. University of Texas Medical Branch, Galveston, TX6. University of Cardiff, Cardiff, Wales, UK7. University of Pennsylvania, Philadelphia, PA8. Private practice, Warren, PA9. Private practice, Tamarac, FL10. University of Pittsburgh, Pittsburgh, PA11. St. Louis University, St. Louis, MO, and12. Washington University, St. Louis, MO

Guidelines for the treatment of arterial insufficiency ulcers

1. Co-chaired panel 2. University of Utah, Salt Lake City, UT 3. University of Texas, San Antonio, TX 4. Sinai Hospital/Johns Hopkins Medical Institutions, Baltimore, MD 5. GKT School of Medicine, King’s College, London, UK 6. University of Texas Health Science Center at Houston, TX 7. Sequoia Hospital, Redwood City, CA 8. Maricopa Medical Center, Phoenix, AZ 9. Tufts-New England Medical Center, Boston, MA 10. Southampton University Hospitals Trust NHS, Southampton, UK 11. Penrose–St. Francis Health Services, Colorado Springs, CO 12. Beverly Surgical Associates, Beverly, MA 13. Saint Francis Memorial Hospital, San Francisco, CA 14. Northbay Center for Wound Care, Vacaville, CA, and 15. University of California, San Francisco, CA

Lactate stimulates endothelial cell migration

The significance of the high lactate levels that characterize healing wounds is not fully understood. Lactate has been shown to enhance collagen synthesis by fibroblasts and vascular endothelial growth factor (VEGF) production by macrophages and endothelial cells. VEGF has been shown to induce endothelial cell migration. However, it has not been shown whether accumulated lactate correlates with the biological activity of VEGF. Therefore, we investigated the effect of lactate on migration of endothelial cells. Human umbilical vein endothelial cells and human microvascular endothelial cells were cultured to subconfluent monolayers in standard six‐well tissue culture plates. Following a 24‐hour serum starvation, cells were treated with the indicated concentrations of l‐lactate. Cell migration was assessed using a modified Boyden chamber. VEGF protein in the cell culture supernatant was measured by enzyme‐linked immunoassay. Lactate‐enhanced VEGF protein synthesis in a time‐ and dose‐dependent manner. Lactate added into the bottom well did not stimulate cellular migration from the upper well. However, lactate when added together with endothelial cells to the bottom well of the Boyden chamber increased cellular migration in a dose‐dependent manner. This effect was blocked by anti‐VEGF and by cycloheximide. Lactate enhances VEGF production in endothelial cells, although lactate, itself, is not a chemoattractant. We conclude that the lactate‐mediated increase in cellular migration is regulated by VEGF.

Guidelines for the prevention of pressure ulcers

The Wound Healing Society is a professional organization of physicians, nurses, physical therapists, basic scientists, clinical researchers, and industrial researchers dedicated to assuring that every patient receives optimal wound care. Its mission is to advance the science and practice of wound healing. To that end, the following comprehensive, evidence- and consensus-based guidelines were developed to address the Prevention of Pressure Ulcers. The guidelines are presented in generic terms; the details of specific tests, therapies, and procedures are the discretion of an interdisciplinary team of health care professionals who establish, implement, and evaluate policies and procedures directed at the prevention of pressure ulcers.

Guidelines for the prevention of venous ulcers

1. Co-chaired this panel,2. University of South Florida, Tampa, Florida,3. Healthpoint Ltd., Fort Worth, Texas,4. Sinai Hospital, Baltimore, Maryland,5. University of Cardiff, Cardiff, Wales, UK,6. University of Pennsylvania, Philadelphia, Pennsylvania,7. Bay Pines VAMC, Bay Pines, Florida,8. Gannon University, Erie, Pennsylvania,9. University Hospital, Tamarac, Florida,10. University of Pittsburgh, Pittsburgh, Pennsylvania,11. St. Louis University, St. Louis, Missouri, and12. Washington University, Barnes Jewish Hospital, St. Louis, Missouri

Guidelines for the prevention of lower extremity arterial ulcers

The Wound Healing Society (WHS) is a professional society of physicians, nurses, physical therapists, podiatrists, and other wound care specialists, basic scientists, clinical researchers, and industrial researchers dedicated to assuring that every patient receives optimal wound care. Its mission is to advance the science and practice of wound healing. To that end, the following comprehensive, evidence- and consensus-based guidelines were developed to address the Prevention of Lower Extremity Arterial Insufficiency Ulcers. The guidelines are presented in generic terms; the details of specific tests, therapies, and procedures are at the discretion of an interdisciplinary team of health care professionals who establish, implement, and evaluate policies and procedures directed at prevention of arterial ulcers.

Wound healing society 2015 update on guidelines for pressure ulcers: Guidelines for the treatment of pressure ulcers

1. Wound Recovery and Hyperbaric Medicine Center, Kent Hospital, Warwick, Rhode Island, 2. Department of Plastic Surgery, The Ohio State University College of Medicine, Columbus, Ohio, 3. University of South Florida Morsani College of Medicine, Tampa, Florida, 4. Departments of Surgery and Physical Medicine and Rehabilitation, Hackensack University Medical Center, Hackensack, New Jersey, 5. American Board of Internal Medicine, Philadelphia, Pennsylvania, 6. Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Seattle, Washington, 7. Department of Musculoskeletal Sciences, Spectrum Health Medical Group, Grand Rapids, Michigan, 8. Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida, 9. Chairman WHS Wound Practice Guideline Committee, 10. Chair WHS Pressure Ulcer Guideline Committee

Preventing, minimizing, and managing pain in patients with chronic wounds: challenges and solutions

php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Chronic Wound Care Management and Research 2016:3 85–90 Chronic Wound Care Management and Research Dovepress

Poster 282 Rehabilitation of the Patient With Chronic Wounds: A Case Report

analysis of survivors of EDT. Setting: Level 1 trauma and tertiary care rehabilitation center. Participants: Patients that survived EDT (n 21). Interventions: Comprehensive inpatient rehabilitation, skilled nursing facility, outpatient comprehensive rehabilitation. Main Outcome Measures: Functional Independence Measure (FIM) instrument scores, Mini-Mental Status Examination, Timed Get-Up and Go Test (TGUG). Results: From 2000-2010, the level I trauma center registry revealed that 37 of 448 patients survived hospitalization after EDT. The patients (n 37) were followed up in 2010 post-EDT survival for long-term outcome measures. Patients lost to follow-up (n 16) were excluded from the analyses. The functional and cognitive statuses were evaluated by an outpatient multidisciplinary assessment: the Mini-Mental Status Examination, TGUG, and FIM Score. Mini-Mental Status Examination revealed a mean score of 25.9 and a median score of 29. Outpatient follow-up FIM scores were assessed for dressing, feeding, bathing, functional transfers, and bed mobility, and all revealed mean scores above 6.5. TGUG showed normal times for 81% of the patients studied. Only 12.5% of the patients were wheelchair dependent. Conclusions: Predictors of hospital survival after EDT are well established, but little is known of functional and cognitive outcomes after hospital survival. The results of this study suggest that the majority of the survivors of EDT had improved functional and cognitive outcomes from discharge. Additional studies are warranted in these EDT survivors to enable a multidisciplinary team to develop suitable individual programs and better allocate resources.