Rune Nyberg

A Technique for Perfusion of the Previable Human Fetus

A perfusion technique of the previable human fetus is described in detail. The fetuses survived 5–12 hours. ECG, blood pressure, and blood flow were recorded simultaneously. Examples of the oxygen consumption of hypo‐ and normo‐thermic fetuses are presented.

Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum.

body surface area in every instance, thus being normal. No correlation between the cardiopulmonary hemodynamics and the crea tinine clearance could be demonstrated. Preoperatively a high filtration fraction was frequently observed in cases with pulmonary hypertension or with shunts exceeding 40 % of the left ventricular output. A positive correlation existed between the shunt through the ductus and the filtration fraction. There was also a slight correlation between the pulmonary arterial pressure and the renal filtration fraction. Postoperatively the para-amino-hipcame entirely normal in the children with a normal pulmonary arterial pressure. In the group which before operation had pulmonary hypertension, the effective renal plasma flow and the renal fraction of the systemic blood flow remained at the lower limits of normal, and the filtration fraction was, on an average, still slightly above normal even postoperatively. However, the last postoperative investigation showed in three of these cases recanalization of the ductus. A high filtration fraction is necessarily not a sign of renal vascular disease. Increased tone in the efferent glomerular purate clearance and the renal fraction of arterioles seems to be of importance in the peripheral blood flow increased in maintaining a normal glomerular filtramost of the cases. The high filtration tion rate in children with patent ductus fraction decreased, on an average, and arteriosus despite decreased blood supply the creatinine clearance remained unto the kidneys. changed. Thus, the renal circulation be-

INTRAAMNIOTIC ADMINISTRATION OF PROSTAGLANDIN F2α FOR THERAPEUTIC ABORTION

Abstract. The present study was made to evaluate the efficiency of intraamniotically administered prostaglandin F2α upon unselected consecutive patients, hospitalized for legal abortion after the 12th week of pregnancy. In the first series, 178 cases were studied and in these the initial dose was related to the size of the uterus, i. e. 25 mg at 13 weeks, up to 40 mg at 24 weeks. A repeat injection of the same dose was required in 21% of the cases. Abortion occurred in 53% within 24 hours and in 81% within 48 hours. The mean abortion time was 32.3 hours. No failures occurred. In the second series, 73 patients were given an initial standardized dose of 40 mg irrespective of the size of the uterus. A repeat injection of 40 mg was given in 11%. Abortion occurred in 67% of the cases within 24 hours and in 80% within 48 hours. Four cases (5%) were failures. The mean time until expulsion of the fetus was 24.3 hours. Side effects in the form of vomiting and/or diarrhoea occurred about 2 times per patient in both series. In 20‐30% a blood loss was sustained of more than 500 ml. Rupture of the cervix occurred in 3 cases. In both series multigravidae aborted faster than primigravidae. Early rupture of the membranes before the cervix was effaced caused very long abortion times in several cases.

Intraamniotic and Intramuscular Administration of 15-Methyl Prostaglandin F2α for Midtrimester Abortion

Abstract. Two series of midtrimester abortion inductions are compared. In one series of 68 cases of midtrimester pregnancies (12–24 weeks), legal abortion was induced by one intraamniotic injection of 2.5 mg 15‐methyl prostaglandin F2α. Fetus was expelled in 67 cases (98.5%) after a mean time of 18.4 hours. One case with duplex failed to abort (1.5%). Abortion was complete in 54% of the aborted cases.