Rupam Karmakar
R. G. Kar Medical College and Hospital
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Publication
Featured researches published by Rupam Karmakar.
Indian Journal of Pathology & Microbiology | 2009
Sumana Mukherjee; Gautam Bandyopadhyay; Chanda Dutta; Aparna Bhattacharya; Rupam Karmakar; Gopinath Barui
Various studies have shown the role of mast cells in chronic inflammatory states and in tumor growth. The study is designed to have an idea of the relationship of mast cell density (MCD) to gastric ulcer and cancer, to verify whether mast cell accumulation occurred in the two conditions especially in Indian patients and thus postulate that therapeutic strategies against mast cell mediators could be useful in treatment. Also, we want to review literature and attempt to explain our findings. A total of 240 patients, who underwent their first endoscopy and biopsy for a span of 21/2 years were studied retrospectively. Out of these, 210 cases that were either gastric ulcers or cancer were chosen for this MCD study. Biopsies were sectioned and stained routinely. Toluidine blue stain and copper grid was used to calculate MCD. Students t-Test was used to calculate the statistical significance of MCD. MCD in benign ulcers was much higher than in control subjects. MCD in well-differentiated cancers showed MCD higher than control. Poorly-differentiated adenocarcinoma showed lower MCD than well-differentiated adenocarcinoma. It was concluded that the accumulation of mast cells in gastric ulcers is an inflammatory response. MCD is increased in well-differentiated gastric cancers, which may be a mast cell mediated immune response or mast cells may have a role in tumor angiogenesis and produce factors for tumor progression. Poorly-differentiated adenocarcinoma apparently lacks mast cell mediated anti-tumor response in some unexplained way.
Journal of Cytology | 2010
Sumana Mukherjee; Gautam Bandyopadhyay; Aparna Bhattacharya; Ritu Ghosh; Gopinath Barui; Rupam Karmakar
Background: Fine needle aspiration cytology (FNAC) may be diagnostic in candidates with indeterminate solitary pulmonary nodules (SPNs) suspicious of bronchogenic carcinoma. Aims: The study was performed to evaluate the usefulness of computed tomography (CT)-guided FNAC in our centre. Materials and Methods: All the cases had a strong clinical suspicion of lung cancer, negative bronchoscopy, negative sputum cytology for malignant cells and acid fast bacilli. A thorough radiological evaluation was made to rule out primary malignancy elsewhere. Results: A total of 94 patients were studied in one year. May-Grünwald-Giemsa stain was used for the smears. The cytological diagnosis was correlated with clinical-radiological follow-up and biopsy to arrive at a final diagnosis. The procedure had a high sensitivity and specificity. Chi-square test was used to calculate statistical significance. Tumor of more than three centimeter and immediate cytological assessment significantly increased the yield. Review of slides added two cases of malignancy that were missed initially. There were very few complications. Conclusions: CT-guided FNAC was an accurate and safe procedure for SPNs.
Indian Journal of Pathology & Microbiology | 2010
Sonia Gon; Bipasa Majumdar; Gopinath Barui; Rupam Karmakar; Aparna Bhattacharya
Indian Journal of Pathology & Microbiology | 2003
Kuntal Chaudhuri; Amitava Sinha; Ganesh Chandra Hati; Rupam Karmakar; Arijit Banerjee
Indian Journal of Pathology & Microbiology | 2006
Ray S; Anuradha D; Barui G; Rupam Karmakar; Amitava Sinha; Aparna Bhattacharya
Journal of the Indian Medical Association | 2012
Sudipta Chakrabarti; Rupam Karmakar; Gopinath Barui; Maity Pk; Bandyopadhyay A; Roy A
Indian Journal of Hematology and Blood Transfusion | 2015
Debjani Mallick; Rupam Karmakar; Gopinath Barui; Sonia Gon; Sudipta Chakrabarti
Journal of Cytology | 2009
Gopi N Barui; Rupam Karmakar; Amitava Sinha; Aparna Bhattacharya
Journal of Cytology | 2008
Gopi N Barui; Rupam Karmakar; Amitava Sinha; Aparna Bhattacharya
Journal of Evolution of medical and Dental Sciences | 2017
Gopinath Barui; Manas Talukdar; Kaberi Datta; Rupam Karmakar