Rupert Conrad

Temperament and character personality profiles and personality disorders in chronic pain patients

Abstract In his psychobiological model of personality, Cloninger developed a novel approach concerning the relationships between psychopathological syndromes and personality. We investigated 207 chronic pain patients (CPPs) and compared them to 105 pain‐free control subjects. Participants were assessed using the Temperament and Character Inventory (TCI), the Structured‐Clinical‐Interview‐II, the Beck Depression Inventory and the Spielberger Anxiety Inventory. The CPPs scored higher on the depression and state anxiety scales and 41% fulfilled the criteria of having at least one personality disorder (PD). We used a covariance analysis to control for depression and state anxiety and found that the CPPs scored higher on the Harm Avoidance Temperament Dimension and lower on the Self‐Directedness and Cooperativeness Character Dimensions. In CPPs, the symptom counts of all PD subtypes were significantly related to low Self‐Directedness and, to a lesser degree, low Cooperativeness. The PD symptoms in Cluster A were related to low Reward Dependence, those in Cluster B were related to high Novelty Seeking and the PD symptoms in Cluster C were related to high Harm Avoidance. In multiple hierarchical regression analyses, controlling for age, gender, depression and state anxiety, TCI scales predicted on average 23% in PD symptom counts. The Self‐Directedness and Cooperativeness personality traits appeared to be significant predictors in determining the presence or absence of a PD by correctly classifying 75.8% of CPPs. The TCI provides further insight into the mechanisms underlying the development of chronic pain. This useful diagnostic instrument helps to economically and validly facilitate the identification of core PD features.

Chorioretinopathia centralis serosa und psychische Belastung

ZusammenfassungHintergrund. Die Ätiologie der Chorioretinopathia centralis serosa ist bis heute nicht sicher geklärt. Vorangegangene Studien diskutierten u. a. inadäquate Bewältigungsstrategien und fehlende soziale Unterstützung bei Belastung als Auslösefaktoren. In der vorliegenden Untersuchung wurde der Frage nach einem Zusammenhang zwischen der Chorioretinopathia centralis serosa und psychischer Belastung nachgegangen. Patienten und Methode. 35 männliche Patienten mit Chorioretinopathia centralis serosa wurden mit einer Kontrollgruppe von 21 männlichen Patienten mit traumatischen Augenleiden verglichen. Neben soziodemographischen Daten und Krankheitssymptomatik wurden Persönlichkeitsfaktoren, kritische Lebensereignisse in der Vorgeschichte, Stressverarbeitung und körperliche Beschwerden untersucht. Ergebnisse. Die Patienten mit Chorioretinopathia centralis serosa zeigten signifikant mehr körperliche (nicht auf die Augensymptomatik bezogene) Beschwerden gemessen mit der Beschwerden-Liste (B-L). Im Freiburger Persönlichkeitsinventar zeigten sie eine höhere emotionale Labilität und Beanspruchung sowie eine niedrigere Extraversion. Schlussfolgerung. Die Ergebnisse der Untersuchung weisen in die Richtung einer höheren psychischen Belastung von Patienten mit Chorioretinopathia centralis serosa als Folge einer unangemessenen Bewältigung, die sich in einer verstärkten Äußerung körperlicher Beschwerden abbildet.AbstractBackground. To date we know little about the etiology of central serous chorioretinopathy. Former investigations discussed inadequate coping strategies and critical life-events as important psychological aspects. In this study we investigated the relationship between central serous chorioretinopathy and stress. Materials and Methods. 35 male patients with central serous chorioretinopathy (group1) were compared to 21 male patients with traumatic eye diseases. The evaluated data included sociodemographic data as well as data regarding the patients coping strategies, critical live-events before outbreak of the disease, personality factors and general physical complaints. Results. Group 1 showed a significantly higher amount of general physical complaints, measured with a complaints questionnaire (B-L). In a personality inventory (FPI-R) it scored significantly higher on the scales emotional instability and strain, significantly lower on the scale extraversion. Conclusion. The results indicate that patients with central serous chorioretinopathy are more stressed because of inadequate coping strategies, which can be seen in a higher amount of physical complaints.

Association between Anxiety and Factors of Coagulation and Fibrinolysis

Background: Psychological stress and anxiety have been shown to produce an activation of coagulation and fibrinolysis. Resulting hypercoagulability is a risk factor for cardiovascular diseases, and could therefore contribute to an increased prevalence of coronary artery disease in anxiety patients. However, hemostasis function has not yet been studied in patients with clinically relevant anxiety disorders. Methods: A group of anxiety patients (panic disorder with agoraphobia or social phobia) and a healthy control group (each n = 29) completed some questionnaires [SCL-K9 (a short form of the SCL-90-R), State Trait Anxiety Inventory, ADS (general depression scale)], and had blood drawn after a 15-min rest period. To assess the reaction of the hemostatic system by global entities, sum scores were computed from parameters of coagulation and fibrinolysis (fibrinogen, FVII, FVIII, vWF, F1 + 2, TAT, D-dimer, α2-AP, PAP, tPA, PAI-1). Interfering variables, such as age, gender, alcohol consumption and smoking status, were controlled. Results: Anxiety patients scored higher in a composite hemostatic score and a sum score of fibrinolysis in comparison to the control group, with a predominant activation of inhibitors in fibrinolysis. However, the psychological variable with the closest association to hemostasis was not trait anxiety, but self-perceived worry about blood drawing before blood sampling was performed. Conclusions: The coagulation and fibrinolysis system is activated in the direction of a hypercoagulable state in patients with severe phobic anxiety, triggered by fear of blood drawing. This could be one mediating factor for the increased risk of cardiovascular diseases in this population. Acute situational phobic anxiety should be monitored closely when studying the association between anxiety and hemostasis.

A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project

We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss. As far as vitamins are concerned, vitamin E in combination with omega‐3 fatty acids displayed an effect on survival in a single study, vitamin D showed improvement of muscle weakness in prostate cancer patients, and vitamin C supplementation led to an improvement of various quality of life aspects in a sample with a variety of cancer diagnoses. For proteins, a combination therapy of β‐hydroxy‐β‐methylbutyrate (HMB), arginine, and glutamine showed an increase in lean body mass after 4 weeks in a study of advanced solid tumour patients, whereas the same combination did not show a benefit on lean body mass in a large sample of advanced lung and other cancer patients after 8 weeks. L‐carnitine led to an increase of body mass index and an increase in overall survival in advanced pancreatic cancer patients. Adverse effects of food supplementation were rare and showed mild intensity. There is not enough solid evidence for the use of minerals, vitamins, proteins, or other supplements in cancer. No serious adverse effects have been reported with dietary supplementation.

Temperament, Character, and Personality Disorders in Chronic Pain

In the past decades investigators have used personality inventories to help explain the relationship between personality and pain experience. This article reviews empirical research, which has examined temperament and character features in chronic pain patients. Robert Cloninger’s temperament and character model of personality based on a bio-psychosocial approach to personality and psychopathology has been used in multiple studies investigating the temperament and character profile of chronic pain patients. According to Cloninger’s model, research portrayed a common personality profile of chronic pain patients characterized by prevailing harm avoidance and lower self-directedness, which has been shown to predict the presence of a personality disorder. Pain-prone patients could benefit from the measurement of personality by the temperament and character inventory with improved treatment response.

Coagulation activation and fibrinolysis impairment are reduced in patients with anxiety and depression when medicated with serotonergic antidepressants.

Aims:  Anxiety disorders have been shown to be correlated with an activation of coagulation and impairment of fibrinolysis. The aim of the study was to assess whether medication with a serotonergic antidepressant, which has been associated with abnormal bleeding, may modify this effect.

CROSS-CULTURAL COMPARISON OF EXPLANATORY MODELS OF ILLNESS IN SCHIZOPHRENIC PATIENTS IN JORDAN AND GERMANY

This study investigated illness concepts of schizophrenic patients in an Arab-Islamic and a western European cultural background. 24 Jordanian and 23 German inpatients were interviewed using an illness concept scale and a causal belief questionnaire. Jordanian patients tend to believe more in esoteric factors underlying their illness, and they perceive the illness to be more threatening. There were no differences regarding biological explanations of illness and trust in medication; however, Jordanian patients reported more trust in the treating physician. Nearly all patients mentioned psychosocial stress as an important factor underlying their illness. Concerning treatment, only Jordanian patients believed religion to be an important factor and mentioned distance from the family as beneficial. The study highlights that culturally specific factors influence illness concepts of schizophrenic patients from an Arab-Islamic and a western European cultural background. Knowledge of these illness concepts is important to establish a helpful relationship between physician and patient.

Schema Change Without Schema Therapy: The Role of Early Maladaptive Schemata for a Successful Treatment of Major Depression

Early maladaptive schemata (EMS) have repeatedly been shown to be associated with several psychopathological conditions, including depression. Schema therapy proposes interventions that aim at altering EMS. In the present study, we examined the effect of an integrative psychodynamic inpatient therapy without explicit focus on EMS in a sample with major depression. Forty-seven (38 female, 9 male) patients filled out the Symptom Checklist (SCL-90-R) and the Young Schema Questionnaire (YSQ) at the beginning and end of the treatment. Results revealed that EMS were significantly reduced in three out of five schema domains. Strong endorsement of EMS at the beginning of treatment tended to predict symptom reduction. More importantly, the reduction of symptom distress during treatment was strongly associated with a reduction in EMS of the schema domain Impaired Autonomy/Performance. We discuss that changes in EMS are highly relevant for changes in symptom distress but that EMS can not only be changed by schema therapy but also by other approaches, like psychodynamic therapy.

Disclosing the cancer diagnosis: what contributes to patient satisfaction?

Despite the growing attention to the how, when and where of disclosing a cancer diagnosis, not all patients are satisfied with how the news is broken to them. As in German-speaking countries there is a lack of empirical studies on this subject, this analysis was conducted to determine how the cancer diagnosis was given in a German sample, and how satisfied the patients are with the disclosure experience. Patients and Methods: 162 outpatients received a self-report questionnaire focusing on their experiences with physician-patient communication when the diagnosis was disclosed. Results: Guidelines had been respected in most cases. 17% of patients were dissatisfied with the diagnosis disclosure. They reported a significantly shorter duration of the interaction, lack of privacy, deficits in understanding the information, and less emotional support by the physician. Conclusion: Adherence to guidelines of diagnosis disclosure in the German sample was fairly high. Respecting both informational and emotional needs is essential for patient satisfaction and can be taught in communication training.

Factorial structure of the 20-item Toronto Alexithymia Scale in a large sample of somatoform patients

Although a strong association between alexithymia and somatization has been postulated in numerous studies, no systematic study has investigated the psychometric properties of the 20-item Toronto Alexithymia Scale (TAS-20) in a sample of patients with somatoform disorder yet. The purpose of this study was to ensure a valid assessment by the German version of the TAS-20 in somatoform samples. We investigated whether the original three-factor model proposed by Bagby et al. (1994a), which is widely used in clinical research and practice, is replicable in a large sample of somatoform patients (n=806). Using confirmatory factor analysis (CFA) the goodness-of-fit of the originally proposed factor structure was compared to three factor models generated with exploratory factor analysis (EFA) and other factorial solutions derived from the literature. Our results demonstrate that the original three-factor model is not replicable in somatoform patients. Instead, the four-factor model by Franz et al. (2001b) described the data best. However, none of the models met all criteria of confirmatory factor analysis. Our results indicate that the three-factor model is not robust in the German version of the TAS-20. At this state of research we recommend to use the TAS-20 sum-score as a measure of alexithymia in somatoform patients in clinical practice.