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Dive into the research topics where Ruslan R. Kashapov is active.

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Featured researches published by Ruslan R. Kashapov.


Russian Chemical Bulletin | 2012

Alkylated 1,4-diazabicyclo[2.2.2]octanes: self-association, catalytic properties, and biological activity

Elena P. Zhiltsova; T. N. Pashirova; Ruslan R. Kashapov; N. K. Gaisin; Oleg I. Gnezdilov; S. S. Lukashenko; A. D. Voloshina; N. V. Kulik; V. V. Zobov; L. Ya. Zakharova; A. I. Konovalov

Aggregation of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide in the presence of diethyl 4-nitrophenyl phosphate was studied using 1H NMR spectroscopy. The quantitative characteristics of the aggregation were determined. The data obtained were used to explain the catalytic effect of micelles on the hydrolysis of the phosphate. It was found that the aggregation properties and biological activity of alkylated mono- and dicationic 1,4-diazabicyclo-[2.2.2]octanes are correlated.


Kinetics and Catalysis | 2011

Catalytic properties of micellar systems based on 4-aza-1-alkyl-1-azoniabicyclo[2.2.2]octane bromides

L. Ya. Zakharova; T. N. Pashirova; Ruslan R. Kashapov; E. P. Zhil’tsova; N. K. Gaisin; Oleg I. Gnezdilov; A. B. Konov; S. S. Lukashenko; I. M. Magdeev

The catalytic effect of micellar systems based on alkylated 1,4-diazabicyclo[2.2.2]octanes on the alkaline hydrolysis of butyl chloromethyl 4-nitrophenyl phosphonate is reported. The catalytic effect is due to the reactants concentrating in the micellar phase. It increases with an increase in the hydrophobicity of the surfactant. The bicyclic surfactant manifests the higher efficiency than its cyclic and noncyclic analogues. The micellization properties of alkylated 1,4-diazabicyclo[2.2.2]octanes in aqueous solutions have been investigated by the NMR method. An increase in the hydrophobicity of the surfactant decreases the critical micelle concentration and increases the hydrodynamic radius and aggregation numbers of the micelles.


Colloids and Surfaces B: Biointerfaces | 2014

Design of supramolecular biomimetic catalysts of high substrate specificity by noncovalent self-assembly of calix[4]arenes with amphiphilic and polymeric amines.

A. B. Mirgorodskaya; Ekaterina I. Yackevich; Yuliana R. Kudryashova; Ruslan R. Kashapov; Svetlana E. Solovieva; Aidar T. Gubaidullin; I. S. Antipin; Lucia Ya. Zakharova; Alexander I. Konovalov

Supramolecular biomimetic catalysts of high substrate specificity are developed based on amphiphilic oxyethylated calix[4]arene bearing iso-nonyl fragments at the upper rim and hexadeca(ethylene glycol) fragments at lower rim (9CO16), and amines of amphiphilic or polymeric nature. Two critical concentrations determined by tensiometry and dye solubilization methods are probably reflect the onset of association process and transition from bimodal to monomodal size distribution revealed by the dynamic light scattering method. Amine components used may form aggregates as well, which is mediated by hydrophobic effect due to occurrence of long-chain alkyl tails. The micellar rate effect of the designed systems toward the cleavage of carboxylic acid ester is shown to be contributed by the formation of mixed aggregates with the reactive functional groups, as well as by the pKa shift of the amine and the character of the distribution of reagents in functional micelles. In the case of long-chain primary amines, an inversion of micellar rate effect (catalysis to inhibition) occurs upon transferring from the less hydrophobic substrate, p-nitrophenyl acetate, to the more hydrophobic analogs, p-nitrophenyl laurate and p-nitrophenyl caprinate. The opposite effect (inhibition of the reaction of p-nitrophenyl acetate and the acceleration of the process of hydrophobic analogs) was observed in systems based on polyethyleneimine.


RSC Advances | 2014

Amphiphilic O-functionalized calix[4]resocinarenes with tunable structural behavior

T. N. Pashirova; E. M. Gibadullina; A. R. Burilov; Ruslan R. Kashapov; Elena P. Zhiltsova; Victor V. Syakaev; Wolf D. Habicher; Mark H. Rümmeli; Alexander I. Konovalov; Lucia Ya. Zakharova

Novel amphiphilic calix[4]resorcinarenes oxyethylated at the upper rim and alkylated at the lower rim (CR–CnH2n+1, here n is the number of carbon atoms in the alkyl substituent; n = 2,5,7,8,9,11) were synthesized, and their association behavior in water-organic solvents was explored. Surface properties and the association behavior of CRs were shown to be strongly controlled by their structure and the nature of the co-solvent. Solely CR–C5H11 demonstrates surface activity in the mixed water–DMF and water–DMSO solutions, while no surface activity occurs in the water–THF mixture. The DLS measurements revealed a very low concentration threshold of the aggregation (around 0.01 mM) for the CR series including surface inactive compounds. In water–DMF and water–DMSO solutions the CRs of low hydrophobicity were shown to associate through an open model with the formation of large aggregates of 300–400 nm, while more hydrophobic CRs can associate through a closed model and form rather small micelle-like aggregates of 10 to 20 nm.


New Journal of Chemistry | 2009

Self-assembly of an aminoalkylated resorcinarene in aqueous media: host–guest properties

Dmitry E. Korshin; Ruslan R. Kashapov; Leisan I. Murtazina; Rezeda K. Mukhitova; Sergey V. Kharlamov; I. S. Ryzhkina; Albina Y. Ziganshina; A. I. Konovalov

A new water-soluble resorcinarene, with a negatively-charged lower rim and a positively-charged upper rim self-assembles into supramolecular oligomers to bind 1,5-diaminonaphthalene in water.


Russian Journal of Electrochemistry | 2014

Binding of 1,5-bis(p-sulfonatophenyl)-3,7-diphenyl-1,5-diaza-3,7-diphosphacyclooctane with tetramethylviologen calix[4]resorcin with a methyl radical in the resorcinol ring

A. Yu. Ziganshina; G. R. Nasybullina; V. V. Yanilkin; N. V. Nastapova; Dmitry E. Korshin; Yu. S. Spiridonova; Ruslan R. Kashapov; Margit Gruner; Wolf D. Habicher; Andrey A. Karasik; A. I. Konovalov

The binding of the amphiphilic 1,5-bis(para-sulfonatophenyl)-3,7-diphenyl-1,5-diaza-3,7-diphosphacyclooctane dianion (APCO2−) with the octacation of the amphiphilic tetramethylviologen calix[4]resorcin having a methyl radical in the resorcinol ring (MVCA-C18+) in 30% aqueous DMSO in a 0.1M NaCl supporting solution was studied by various methods. The dianion was bound at the upper rim of calixresorcin due to the donor-acceptor interactions between the viologen acceptor units and the nitrogen- and phosphorus-centered electron-donor fragments of APCO2− and at the lower rim due to hydrophobic interactions. The composition of the complex depended on the MVCA-C18+: APCO2− ratio. The complexes aggregated, forming insoluble precipitates. MVCA-C18+-APCO2− is a system with reversibly electro-switchable aggregation. The starting MVCA-18+ octacation partially bound APCO2−, a certain quantity of both substrates remaining in a free state in solution. The MVCA-C14+· tetraradical tetracation formed as a result of the reduction of MVCA-C18+ completely bound APCO2− due to hydrophobic interactions when the MVCA-C18+: APCO2− ratio was 1: 3. The reversible oxidation of MVCA-C14+· to the starting MVCA-C18+ octacation brought the system back to its starting state


Chemistry: A European Journal | 2014

Controlling the Size and Morphology of Supramolecular Assemblies of Viologen–Resorcin[4]arene Cavitands

Ruslan R. Kashapov; Sergey V. Kharlamov; Elza D. Sultanova; Rezeda K. Mukhitova; Yuliana R. Kudryashova; Lucia Ya. Zakharova; Albina Y. Ziganshina; Alexander I. Konovalov

A novel class of self-assembling nanoparticles is formed with viologen-resorcin[4]arene cavitands; the association model is strongly controlled by their hydrophobicity. Interestingly, the cavitand assemblies are designed through click chemistry to form self-assembled noncovalently connected aggregates through counterion displacement. The iodide and benzoate ions are utilized as strongly polarizable counterions to induce cavitand self-assembly. The counterion-mediated decrease in hydrophilicity of the viologen-resorcin[4]arenes is the underlying trigger to induce particle formation. These particles can be used as nanocontainers and find their applications in delivery systems.


Russian Journal of Physical Chemistry A | 2012

Supramolecular Systems Based on Aminomethylated Calix(4)resorcinarene and a Cationic Surfactant: Catalysts of the Hydrolysis of Esters of Phosphorus Acids

Ruslan R. Kashapov; T. N. Pashirova; Elena P. Zhiltsova; S. S. Lukashenko; A. Yu. Ziganshina; L. Ya. Zakharova

Kinetics of alkaline hydrolysis of 4-nitrophenyl esters of tetracoordinated phosphorus acids in micellar solutions of aminomethylated calix[4]resorcinarene containing sulfonatoethylene groups on the lower rim of the macrocycle, 4-aza-1-hexadecyl-azoniabicyclo[2.2.2]octane bromide and their mixtures was investigated spectrophotometrically. It is established that the catalytic effect of aggregates depends on the concentration of calixarene and surfactants, pH, presence of lanthanum salt and reaches more than two orders of magnitude. The parameters of the catalyzed reactions and their dependence on the composition are determined.


RSC Advances | 2016

Controlling the release of hydrophobic compounds by a supramolecular amphiphilic assembly

Ruslan R. Kashapov; Regina I. Rassadkina; Albina Y. Ziganshina; Rezeda K. Mukhitova; V. A. Mamedov; Nataliya A. Zhukova; Marsil K. Kadirov; Irek R. Nizameev; Lucia Ya. Zakharova; O. G. Sinyashin

Here, we report a novel approach of using a supramolecular system based on calix[4]resorcinarene and surfactant to facilitate the release of hydrophobic compounds. This finding is an important step towards the development of controlled-release formulations for water-insoluble drugs.


Encapsulations#R##N#Nanotechnology in the Agri-Food Industry Volume 2 | 2016

Supramolecular strategy of the encapsulation of low-molecular-weight food ingredients

Lucia Ya. Zakharova; A. B. Mirgorodskaya; Gulnara A. Gaynanova; Ruslan R. Kashapov; T. N. Pashirova; E. A. Vasilieva; Yuriy F. Zuev; Oleg Synyashin

Abstract A large number of additives (stabilizers, preservatives, vitamins, and nutraceuticals) are scarcely soluble in polar media, and therefore poorly mix with aqueous food dispersion. Besides, they are unstable against light, temperature, pH changing, and oxygen. Therefore, design of effective nanocontainers with controlled binding/release functions toward active components remains a challenge in the food industry. The chapter is oriented on the elucidation of recent trends in the field of engineering of delivery and storage systems for food ingredients. According to modern nanotechnological criteria and the green chemistry approach, food formulations tend to be polycomponent and polyfunctional, with natural and low toxic synthetic materials receiving special attention. Several lines of investigations have been reviewed, including the amphiphile- and polymer-based nanocontainers, supramolecular guest–host strategies involving macrocycle platforms, as well as binding/release behavior of loads.

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S. S. Lukashenko

Russian Academy of Sciences

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T. N. Pashirova

Russian Academy of Sciences

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O. G. Sinyashin

Russian Academy of Sciences

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Elena P. Zhiltsova

Russian Academy of Sciences

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L. Ya. Zakharova

Russian Academy of Sciences

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Marsil K. Kadirov

Russian Academy of Sciences

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