Russell Robert Gettig
Rensselaer Polytechnic Institute
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Featured researches published by Russell Robert Gettig.
Avian Diseases | 1996
Jill Taylor; Lance Christensen; Russell Robert Gettig; Jacqueline Goebel; Jean-Francois Bouquet; Thomas R. Mickle; Enzo Paoletti
A fowl pox-based recombinant virus TROVAC-NDV (vFP96.5) was developed expressing the fusion and hemagglutinin-neuraminidase glycoproteins from a velogenic strain of Newcastle disease virus (NDV). Studies in specific-pathogen-free birds indicated that inoculation of a single dose of the recombinant led to the induction of significant levels of hemagglutination-inhibiting antibody that were maintained to 8 wk postinoculation. Further, the recombinant induced protective immunity against a combined intramuscular velogenic NDV challenge and respiratory NDV challenge. In commercial broiler chickens that were inoculated in the presence of maternally derived NDV immunity, the level of the NDV-specific humoral response was dampened, but significant levels of protection against both a lethal intramuscular NDV challenge and a fowl poxvirus challenge were obtained.
Archive | 1995
William I. Cox; Russell Robert Gettig; Enzo Paoletti
Since the pioneering studies of Edward Jenner on using live virus vaccines during the early 1800s (Baxby 1981), a considerable amount of information has been obtained on the biology and replication of poxviruses. Vaccinia virus, the agent used to vaccinate humans against smallpox and eradicate this disease, has been widely studied in the laboratory due to their large size and ease of growth in tissue culture. With advances in molecular biology and genetic engineering techniques during the past two decades, a large amount of information on the genomic organization and gene expression in vaccinia virus has accumulated. With this information came the ability to insert and express foreign genes under the control of vaccinial promoters (Panicali and Paoletti 1982; Mackett, Smith and Moss 1982). What follows in this section will be a brief description of the basic virology and molecular biology of poxviruses, with emphasis on those aspects important in using poxviruses as expression vectors. (Cited references are meant to be illustrative but not comprehensive. For more indepth coverage, the reader is directed to the following reviews: Fenner, Wittek and Dumbell 1989; Moss 1990a; Buller and Palumbo 1991; Moss 1992).
Archive | 1993
Enzo Paoletti; Marion E. Perkus; Jill Taylor; James Tartaglia; Elizabeth K. Norton; Michel Riviere; Charles de Taisne; Keith J. Limbach; Gerard P. Johnson; Steven E. Pincus; William I. Cox; Jean-Christophe Audonnet; Russell Robert Gettig
Archive | 1998
James Tartaglia; William I. Cox; Russell Robert Gettig; Hector Martinez; Enzo Paoletti; Steven E. Pincus
Archive | 1995
Enzo Paoletti; Marion E. Perkus; Jill Taylor; James Tartaglia; Elizabeth K. Norton; Michel Riviere; Charles de Taisne; Keith J. Limbach; Gerard P. Johnson; Steven E. Pincus; William I. Cox; Jean-Christophe Audonnet; Russell Robert Gettig
Archive | 1996
Enzo Paoletti; Marion E. Perkus; Jill Taylor; James Tartaglia; Elizabeth K. Norton; Michel Riviere; Charles de Taisne; Keith J. Limbach; Gerard P. Johnson; Steven E. Pincus; William I. Cox; Jean-Christophe Audonnet; Russell Robert Gettig
Archive | 1995
Enzo Paoletti; Marion E. Perkus; Jill Taylor; James Tartaglia; Elizabeth K. Norton; Michel Riviere; Charles de Taisne; Keith J. Limbach; Gerard P. Johnson; Steven E. Pincus; William I. Cox; Jean-Christophe Audonnet; Russell Robert Gettig
Archive | 1994
Enzo Paoletti; Jill Taylor; Russell Robert Gettig
Archive | 1996
Enzo Paoletti; Russell Robert Gettig
Archive | 1995
Enzo Paoletti; Jill Taylor; Russell Robert Gettig