Ruth D. Peterson

EFFECT OF TOTAL BODY X-IRRADIATION ON GLUTATHIONE LEVELS IN RATS

Summary A study has been made of blood and liver glutathione after 500 r total body x-irradiation. The data show first, that irradiation generally causes a decrease in blood glutathione; and second, in some cases, a decrease in liver glutathione.

The effect of glycocyamine on the high-energy phosphate fractions in rat muscle

Abstract A single dose of glycocyamine and betaine increased the creatine phosphate levels in the skeletal muscles of adult rats to a slight but statistically significant extent. The creatine phosphate returned to control values between 6 and 12 days. Daily ingestion of glycocyamine over a 98-day period produced the same, but no greater increase, in creatine phosphate.

The effects of antihistaminic drugs upon the excretion of ascorbic acid by rats

Abstract 1.1. The results of our experiments show that Benadryl, Thephorin, Pyribenzamine, and Trimeton stimulate ascorbic acid synthesis in the rat while Neo-Antergan, Histadyl, and Antistine have little or no effect. 2.2. The stimulating action did not correlate with the narcotic effects of the drugs since Thephorin is somewhat stimulating and yet caused as much increase in ascorbic acid excretion as did Benadryl.

Effect of glycocyamine and betaine on creatine phosphate levels in muscle of adrenalectomized rats

Abstract Adrenalectomized, adult, female rats with a negative water-tolerance test for functional adrenal tissue and supplemented with NaCl were used in a study of muscle phosphate fractions and creatine values. Adrenalectomy decreases the creatine phosphate (CrP) levels in skeletal but not in heart muscle. The administration of glycocyamine and betaine raises the CrP level in skeletal but not in heart muscle of adrenalectomized rats. There is no effect on the levels of the other phosphate fractions or creatine in either case.