Ruth Sahler
Heidelberg University
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Publication
Featured researches published by Ruth Sahler.
Journal of Cataract and Refractive Surgery | 2016
Ruth Sahler; Josef F. Bille; Sean Enright; Somaly Chhoeung; Kevin Chan
Purpose To assess the efficiency and effectiveness of the technology that creates a hydrophilicity‐based refractive index change within a standard intraocular lens (IOL) to alter the refractive characteristics of the IOL. Setting Perfect Lens LLC, Irvine, California, USA. Design Experimental study. Methods The IOL used in this experiment was a standard hydrophobic model (EC‐1Y). The refractive index of the material was changed by exposure of the material to a femtosecond laser and the subsequent absorption of water by the material. An experimental system using a femtosecond laser, an acoustic‐optic modulator, beam‐shaping optics, a scan system, and an objective lens was used to create the refractive index change within the IOL. Experiments were performed to determine the optimum wavelength, energy per pulse, and line spacing to produce the refractive index shaping lens. A power and modulation transfer function (MTF) measurement device for refractive and diffractive IOLs was used to measure the diopter and MTF before and after the creation of the refractive index shaping lens. Results The technology successfully altered the refractive characteristics of the IOL. The refractive index change altered the diopter (D) of the IOL (to within ±0.1 D of the targeted change) without significant diminution in the MTF (<0.1 or MTF ≥0.51 for the 100 lp/mm measurement). Conclusion The refractive properties of an IOL can be altered by building a refractive index shaping lens within an IOL using a femtosecond laser with minimal diminution in MTF. Financial Disclosure All authors are employed by Perfect Lens, LLC and have a financial interest in the products of Perfect Lens, LLC.
Biomedical Optics Express | 2017
Josef F. Bille; Johann Engelhardt; Hans-Robert Volpp; Abdelmoutalib Laghouissa; Marcus Motzkus; Zhongxiang Jiang; Ruth Sahler
The chemical basis for the alteration of the refractive properties of an intraocular lens with a femtosecond laser was investigated. Three different microscope setups have been used for the study: Laser Induced Fluorescence (LIF) microscopy, Raman microscopy and coherent anti-Stokes Raman Scattering (CARS) microscopy. Photo-induced hydrolysis of polymeric material in aqueous media produces two hydrophilic functional groups: acid group and alcohol group. The spectral signatures identify two of the hydrophilic polar molecules as N-phenyl-4-(phenylazo)-benzenamine (C18H15N3) and phenazine-1-carboxylic acid (C13H8N2O2). The change in hydrophilicity results in a negative refractive index change in the laser-treated areas.
Archive | 2014
Ruth Sahler; Stephen Q. Zhou; Josef F. Bille
Investigative Ophthalmology & Visual Science | 2011
Ruth Sahler; Josef F. Bille; Stephen Q. Zhou; Rick Aguilera; David J. Schanzlin
Archive | 2017
Josef F. Bille; Ruth Sahler
Archive | 2016
Ruth Sahler; Stephen Q. Zhou; Bille Josef F
Archive | 2015
Ruth Sahler; Stephen Q. Zhou; Josef F. Bille
Archive | 2013
Ruth Sahler; Stephen Q. Zhou; Josef F. Bille
Archive | 2013
Ruth Sahler; Stephen Q. Zhou; Josef F. Bille
Archive | 2013
Ruth Sahler; Stephen Q. Zhou; Josef F. Bille