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Publication
Featured researches published by Ryoichi Misaka.
World Journal of Diabetes | 2015
Mariko Tsuchiya; Ryoichi Misaka; Kosaku Nitta; Ken Tsuchiya
The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs.
World Journal of Gastroenterology | 2014
Mikiko Fujita; Yuri Nakamura; Saeko Kasashima; Maiko Furukawa; Ryoichi Misaka; Hikaru Nagahara
AIM To elucidate risk factors associated with dysplasia of short-segment Barretts esophagus (BE). METHODS A total of 151 BE patients who underwent endoscopic examination from 2004 to 2008 in Aoyama Hospital, Tokyo Womens Medical University, Japan and whose diagnosis was confirmed from biopsy specimens were enrolled in the study. BE was diagnosed based on endoscopic findings of gastric-appearing mucosa or apparent columnar-lined esophagus proximal to the esophagogastric junction. Dysplasia was classified into three grades - mild, moderate and severe - according to the guidelines of the Vienna Classification System for gastrointestinal epithelial neoplasia. Anthropometric and biochemical data were analyzed to identify risk factors for BE dysplasia. The prevalence of Helicobacter pylori (H. pylori) infection and the expression of p53 by immunohistological staining were also investigated. RESULTS Histological examination classified patients into three types: specialized columnar epithelium (SCE) (n = 65); junctional (n = 38); and gastric fundic (n = 48). The incidence of dysplasia or adenocarcinoma from BE of the SCE type was significantly higher than that of the other two types (P < 0.01). The univariate analysis revealed that sex, H. pylori infection, body weight, p53 overexpression, and low diastolic blood pressure (BP) were associated with BE dysplasia. In contrast, body mass index, waist circumference, metabolic syndrome complications, and variables related to glucose or lipid metabolism were not associated with dysplasia. Multivariate logistic analysis showed that overexpression of p53 [odds ratio (OR) = 13.1, P = 0.004], H. pylori infection (OR = 0.19, P = 0.066), and diastolic BP (OR = 0.87, P = 0.021) were independent risk factors for epithelial dysplasia in BE patients with the SCE type. CONCLUSION Overexpression of p53 is a risk factor for dysplasia of BE, however, H. pylori infection and diastolic BP inversely associated with BE dysplasia might be protective.
Internal Medicine | 2010
Maiko Furukawa; Saeko Kasajima; Yuri Nakamura; Meiko Shouzushima; Naho Nagatani; Akira Takinishi; Ayumi Taguchi; Mikiko Fujita; Akiko Niimi; Ryoichi Misaka; Hikaru Nagahara
Pediatric Dermatology | 2003
Takayuki Ishikawa; Kazumasa Shimura; Etuko Takeuchi; Akiko Yanagisawa; Syoji Ogihara; Midori Furukawa; Mariko Tsuchiya; Masumi Akimoto; Akiko Niimi; Ryoichi Misaka; Atsushi Kurihara; Jun Maeda; Mutsuo Shigemoto; Katsuko Yamashita; Hideo Ooishi; Hironari Shindo
Internal Medicine | 2011
Maiko Furukawa; Mikiko Fujita; Akira Takinishi; Ryoichi Misaka; Hikaru Nagahara
Pediatric Dermatology | 2007
Kazumasa Shimura; Ryoichi Misaka; Yuko Furuichi; Yuko Kuboki; Etsuko Takeuchi; Junko Hotta; Takayuki Ishikawa; Akiko Niimi; Mutsuo Shigemoto; Athushi Maeda; Tetsuo Imamura
Ningen dock : official journal of the Japanese Society of Human Dry Dock | 2007
Akiko Niimi; Atsushi Maeda; Mutsuo Shigemoto; Ryoichi Misaka; Masatoshi Kawana
Pediatric Dermatology | 2006
Akira Nagao; Ryoichi Misaka; Emi Hirayama; Yuko Kuboki; Yoko Iga; Nozomi Kazuka; Junko Hotta; Etsuko Takeuchi; Takayuki Ishikawa; Akiko Niimi; Mutsuo Shigemoto; Atsushi Maeda; Tetsuo Imamura
Pediatric Dermatology | 2006
Kazumasa Shimura; Ryoichi Misaka; Maiko Furukawa; Yuko Furuichi; Yuko Kuboki; Junko Hotta; Takayuki Ishikawa; Akiko Niimi; Mutsuo Shigemoto; Hideto Ooishi; Athushi Maeda; Michihiko Masuda; Tetsuo Imamura
Pediatric Dermatology | 2005
Nozomi Kazuka; Ryoichi Misaka; Naoko Yokoyama; Mikiko Fuzita; Junko Omori; Etsuko Takeuchi; Takayuki Ishikawa; Shoji Ogihara; Mariko Tsuchiya; Akiko Niimi; Atsushi Maeda; Mutsuo Shigemoto; Katsuko Yamashita; Tetsuo Imamura