S. A. Lewis
University of Southampton
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by S. A. Lewis.
Clinical & Experimental Allergy | 2005
J. O'b. Hourihane; Kate Grimshaw; S. A. Lewis; R.A. Briggs; J. B. Trewin; R. M. King; Sally Kilburn; J. O. Warner
Background The severity of allergic reactions to food appears to be affected by many interacting factors. It is uncertain whether challenge‐based reactions reflect the severity of past reactions or can predict future risk.
Pediatric Allergy and Immunology | 2003
Jane S. Lucas; S. A. Lewis; Jonathan O'b Hourihane
Allergy to kiwi fruit was first described in 1981, and there have since been reports of the allergy presenting with a wide range of symptoms from localized oral allergy syndrome (OAS) to life‐threatening anaphylaxis. The article reviews the available information concerning the clinical features of kiwi fruit allergy and the role of clinical investigations for diagnosis. Work identifying the major allergens in kiwi fruit has resulted in conflicting results, the possible reasons for which are discussed. The clinical associations of kiwi fruit allergy with allergies to pollens or latex are reviewed.
Clinical & Experimental Allergy | 2005
G. H. S. Vance; S. A. Lewis; Kate Grimshaw; P. J. Wood; R.A. Briggs; Catherine A. Thornton; J. O. Warner
Background Maternally derived allergens may be transferred to the developing infant during pregnancy and lactation. However, it is not known how manipulation of environmental allergen levels might impact on this early‐life exposure.
Clinical & Experimental Allergy | 2005
S. A. Lewis; Kate Grimshaw; J. O. Warner; J. O'b. Hourihane
Background IgE binding to a specific protein has been shown to be associated with severe anaphylaxis to hazelnuts; however, the relationship between IgE binding to specific peanut allergens and symptom severity is currently unclear.
Clinical & Experimental Allergy | 2004
G. H. S. Vance; Kate Grimshaw; Roger Briggs; S. A. Lewis; Mark Mullee; Catherine A. Thornton; John O. Warner
Background The value of allergen elimination diets during pregnancy for primary prevention of infant allergy has been questioned. However, dietary compliance may influence effectiveness.
Pediatric Allergy and Immunology | 2005
Jane S. Lucas; S. A. Lewis; Jennifer B. Trewin; Kate Grimshaw; J. O. Warner; Jonathan O'b Hourihane
Actinidia chinensis (gold kiwi) is a newly available fruit which has been shown to have in vitro immunoglobulin E (IgE) cross‐reactivity with green kiwi. This is the first study to investigate clinical reactivity of gold kiwi. Five patients clinically allergic to green kiwi were investigated by skin test and double‐blind placebo controlled food challenge (DBPCFC) with gold kiwi fruit. IgE‐binding patterns of individual sera from the five challenged patients and a pool of sera from a further nine patients with kiwi allergy were compared in the two fruits by Western blotting. Cross reactivity of proteins in the two fruits was assessed by inhibition of immunoblots and by IgE enzyme‐linked immunosorbent assay (ELISA) inhibition. Four of the five patients had a positive DBPCFC to gold kiwi. Western blotting showed marked differences in the allergen patterns of green and gold kiwi. However, inhibition of the immunoblots and ELISA assay reveals extensive inhibition of IgE binding to proteins in each fruit by the alternative species. Gold kiwi fruit is allergenic and patients allergic to green kiwi are at risk of reacting to the gold kiwi fruit. Despite having different protein profiles and IgE‐binding patterns, the two species have proteins that extensively cross‐inhibit the binding to IgE.
Pediatric Allergy and Immunology | 2007
Fatima El-Khouly; S. A. Lewis; L. Pons; A. Wesley Burks; Jonathan O'b Hourihane
The role of antibody avidity in allergy is poorly understood and there is no existing literature describing antibody avidity in food allergy. The main aim of this study was to investigate IgE and IgG avidity to a total peanut protein extract (TPPE) and purified Ara h 2 in a group of well‐characterized peanut allergic individuals. Forty peanut allergic patients underwent a double‐blind placebo‐controlled low‐dose peanut challenge, during which the severity of the patients’ peanut allergy was scored. Serum peanut‐specific IgE (psIgE) and IgG (psIgG) concentrations were measured for 37 individuals and the avidities of the same antibodies to a TPPE and purified Ara h 2 were determined using a thiocyanate ELISA method. Both IgE and IgG avidity to Ara h 2 showed weak positive correlations with challenge score [r = 0.459 (p = 0.012) and r = 0.486 (p = 0.003), respectively]. IgE avidity to TPPE showed a weak positive correlation with skin prick test results (SPT), r = 0.467 (p = 0.004) and there was an inverse relationship between the ratio of total IgE:psIgE and challenge score r = −0.561 (p < 0.001). No significant relationship was found between the ratios of IgE avidity:IgG avidity and challenge score or SPT. This is the first description of IgE and IgG avidity in peanut allergy, and it appears that the avidities of IgE and IgG antibodies to purified Ara h 2 are weakly related to the severity of peanut allergy (as measured by a challenge score).
The Journal of Allergy and Clinical Immunology | 2004
S. A. Lewis; J. O. Warner; Jonathan O'b Hourihane; Jane S. Lucas
The Journal of Allergy and Clinical Immunology | 2006
S. A. Lewis; F. El-Khouly; L. Pons; Wesley Burks; J.O. Hourihane
Archive | 2004
Jane S. Lucas; S. A. Lewis; Kate Grimshaw; J.A. Warner; Jonathan O'b Hourihane