S. Christopher Davis
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Featured researches published by S. Christopher Davis.
Nature Biotechnology | 2007
Richard J. Fox; S. Christopher Davis; Emily Mundorff; Lisa M. Newman; Vesna Gavrilovic; Steven K Ma; Loleta M Chung; Charlene Ching; Sarena Tam; Sheela Muley; John H. Grate; John M. Gruber; John C Whitman; Roger A. Sheldon; Gjalt W. Huisman
We describe a directed evolution approach that should find broad application in generating enzymes that meet predefined process-design criteria. It augments recombination-based directed evolution by incorporating a strategy for statistical analysis of protein sequence activity relationships (ProSAR). This combination facilitates mutation-oriented enzyme optimization by permitting the capture of additional information contained in the sequence-activity data. The method thus enables identification of beneficial mutations even in variants with reduced function. We use this hybrid approach to evolve a bacterial halohydrin dehalogenase that improves the volumetric productivity of a cyanation process ∼4,000-fold. This improvement was required to meet the practical design criteria for a commercially relevant biocatalytic process involved in the synthesis of a cholesterol-lowering drug, atorvastatin (Lipitor), and was obtained by variants that had at least 35 mutations.
Archive | 2004
S. Christopher Davis; John H. Grate; David R Gray; John M. Gruber; Gjalt W. Huisman; Steven K Ma; Lisa M. Newman; Roger Sheldon; Li A Wang
Archive | 2003
S. Christopher Davis; John H. Grate; David R Gray; John M. Gruber; Gjalt W. Huisman; Steven K Ma; Lisa M. Newman; Roger Sheldon; Li A Wang
Archive | 2005
S. Christopher Davis; Richard J. Fox; Gjalt W. Huisman; Vesna Gavrilovic; Emily Mundorff; Lisa M. Newman
Archive | 2004
S. Christopher Davis; Stephane J. Jenne; Anke Krebber; Gjalt W. Huisman; Lisa M. Newman
Archive | 2010
S. Christopher Davis; Stephane J. Jenne; Anke Krebber; Lisa M. Newman
Archive | 2004
Anke Krebber; Lisa M. Newman; S. Christopher Davis; Stephane J. Jenne
Journal of Statistical Planning and Inference | 2009
Richard J. Fox; David Elgart; S. Christopher Davis
Archive | 2006
S. Christopher Davis; Richard J. Fox; Vesna Gavrilovic; Gjalt W. Huisman; Lisa M. Newman
Archive | 2009
Linda A. Castle; Teddy Chen; Anthony Cox; S. Christopher Davis; Robin Emig; Richard J. Fox; Rebecca Gorton; Sridar Govindarajan; Claes Gustafsson; Jeremy Minshull; Phil Patten; Ajoy Roy; Daniel L. Siehl; ロイ アジョイ; コックス アンソニー; クリストファー デイビス エス; ガスタフソン クラエス; ミンシャル ジェレミー; ゴビンダラジャン スリダー; エル. シエル ダニエル; チェン テディー; パッテン フィル; ジョン フォックス リチャード; エー. キャッスル リンダ; リーン ゴートン レベッカ; エミグ ロビン