S. Graf

Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial

BACKGROUND Enteral nutrition (EN) is recommended for patients in the intensive-care unit (ICU), but it does not consistently achieve nutritional goals. We assessed whether delivery of 100% of the energy target from days 4 to 8 in the ICU with EN plus supplemental parenteral nutrition (SPN) could optimise clinical outcome. METHODS This randomised controlled trial was undertaken in two centres in Switzerland. We enrolled patients on day 3 of admission to the ICU who had received less than 60% of their energy target from EN, were expected to stay for longer than 5 days, and to survive for longer than 7 days. We calculated energy targets with indirect calorimetry on day 3, or if not possible, set targets as 25 and 30 kcal per kg of ideal bodyweight a day for women and men, respectively. Patients were randomly assigned (1:1) by a computer-generated randomisation sequence to receive EN or SPN. The primary outcome was occurrence of nosocomial infection after cessation of intervention (day 8), measured until end of follow-up (day 28), analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00802503. FINDINGS We randomly assigned 153 patients to SPN and 152 to EN. 30 patients discontinued before the study end. Mean energy delivery between day 4 and 8 was 28 kcal/kg per day (SD 5) for the SPN group (103% [SD 18%] of energy target), compared with 20 kcal/kg per day (7) for the EN group (77% [27%]). Between days 9 and 28, 41 (27%) of 153 patients in the SPN group had a nosocomial infection compared with 58 (38%) of 152 patients in the EN group (hazard ratio 0·65, 95% CI 0·43-0·97; p=0·0338), and the SPN group had a lower mean number of nosocomial infections per patient (-0·42 [-0·79 to -0·05]; p=0·0248). INTERPRETATION Individually optimised energy supplementation with SPN starting 4 days after ICU admission could reduce nosocomial infections and should be considered as a strategy to improve clinical outcome in patients in the ICU for whom EN is insufficient. FUNDING Foundation Nutrition 2000Plus, ICU Quality Funds, Baxter, and Fresenius Kabi.

Diarrhoea in the ICU: respective contribution of feeding and antibiotics

IntroductionDiarrhoea is frequently reported in the ICU. Little is known about diarrhoea incidence and the role of the different risk factors alone or in combination. This prospective observational study aims at determining diarrhoea incidence and risk factors in the first 2 weeks of ICU stay, focusing on the respective contribution of feeding, antibiotics, and antifungal drugs.MethodsOut of 422 patients consecutively admitted into a mixed medical–surgical ICU during a 2-month period, 278 patients were included according to the following criteria: ICU stay >24 hours, no admission diagnosis of gastrointestinal bleeding, and absence of enterostomy or colostomy. Diarrhoea was defined as at least three liquid stools per day. Diarrhoea episodes occurring during the first day in the ICU, related to the use of laxative drugs or Clostridium difficile infection, were not analysed. Multivariate and stratified analyses were performed to determine diarrhoea risk factors, and the impact of the combination of enteral nutrition (EN) with antibiotics or antifungal drugs.ResultsA total of 1,595 patient-days were analysed. Diarrhoea was observed in 38 patients (14%) and on 83 patient-days (incidence rate: 5.2 per 100 patient-days). The median day of diarrhoea onset was the sixth day, and 89% of patients had ≤4 diarrhoea days. The incidence of C. difficile infection was 0.7%. Diarrhoea risk factors were EN covering >60% of energy target (relative risk = 1.75 (1.02 to 3.01)), antibiotics (relative risk = 3.64 (1.26 to 10.51)) and antifungal drugs (relative risk = 2.79 (1.16 to 6.70)). EN delivery per se was not a diarrhoea risk factor. In patients receiving >60% of energy target by EN, diarrhoea risk was increased by the presence of antibiotics (relative risk = 4.8 (2.1 to 13.7)) or antifungal drugs (relative risk = 5.0 (2.8 to 8.7)).ConclusionDiarrhoea incidence during the first 2 weeks in a mixed population of patients in a tertiary ICU is 14%. Diarrhoea risk factors are EN covering >60% of energy target, use of antibiotics, and use of antifungal drugs. The combination of EN covering >60% of energy target with antibiotics or antifungal drugs increases the incidence of diarrhoea.

Comparison of three indirect calorimetry devices and three methods of gas collection: A prospective observational study

BACKGROUND & AIMS Indirect calorimetry was performed for a long time with the DeltatracII(®) device (Datex, Finland), considered as a reference but no longer produced. This study aims at comparing the energy expenditure (EE), the volume of oxygen (VO2) and carbon dioxide (VCO2) measured by two new available indirect calorimeters, the QuarkRMR(®) (Cosmed, Italy) and the CCMexpress(®) (MedGraphic,USA), using three different methods of gas collection, with the DeltatracII(®) in healthy subjects. METHODS Twenty-four healthy subjects (15 women and 9 men, age 53 ± 15 yrs, mean BMI 25.5 ± 7.1 kg/m(2)) underwent measurements of EE with DeltatracII(®) using canopy, QuarkRMR(®) using canopy and CCMexpress(®) using canopy, face tent and facemask. All measurements were performed for 10 min in random order. Results are presented as mean ± SD and compared by linear regression, repeated measure one-way ANOVA with Bonferronis post hoc test and Bland & Altman test. RESULTS EE was 1630 ± 340 kcal for DeltatracII(®) and 1607 ± 307 kcal, 1741 ± 360 kcal, 1666 ± 315 and 1626 ± 336 kcal for QuarkRMR(®) and CCMexpress(®) with canopy, face tent and facemask, respectively (p = 0.001). Compared to DeltatracII(®), Bland & Altman test showed a mean EE difference (2SD) of 24(220)kcal for QuarkRMR(®), and -111(260) kcal, -36(304) kcal, 5(402) kcal for CCMexpress(®) with canopy, face tent and facemask, respectively. There was no systematic over- or underestimation with any device or gas collection method. CONCLUSION Mean EE was similar between QuarkRMR(®) and DeltatracII(®) but not between CCMexpress(®), in any mode of gas collection, and DeltatracII(®). Bland & Altman test shows a large variability in EE differences with both devices compared to DeltatracII(®), highlighting the need for refining their accuracy.

Prescription and indication for oral nutritional supplements in a Swiss university hospital: a prospective survey

AIMS OF THE STUDY Patients with an acute or chronically negative nutritional balance are at nutritional risk. Oral nutritional supplements (ONS) are simple and effective medical treatments of nutritional risk. In the ambulatory setting, in Switzerland, ONS are reimbursed by public insurance under conditions defined by Swiss Society for Clinical Nutrition. The reimbursement requires a medical prescription for ONS and their delivery at the patients home by a homecare service. The indication for the ONS, defined as a Nutritional Risk Screening-2002 (NRS-2002) score ≥3, must also be present. This survey aimed to document: (i) the existence of a medical prescription for ONS during hospitalisation and discharge for home, (ii) the adequacy of the indication for ONS during hospitalisation and at discharge for home, and (iii) the continuation or not of ONS treatment 1 month after discharge for home. METHODS This prospective survey included adult patients hospitalised in the departments of surgery, medicine or rehabilitation and who were about to receive ONS for the first time. Patients already on ONS, with major consciousness disorders, who refused to take ONS or to participate to the survey were excluded. The existence of a medical prescription for ONS and the adequacy of the indication (Nutritional Risk Screening-2002 [NRS-2002] score ≥3) were evaluated at first ONS delivery and at hospital discharge. At home, the continuation of ONS consumption was evaluated by the homecare service 1 month after discharge. Results are presented as mean ± standard deviation or frequencies and percentages, and comparisons between patients with and without ONS at discharge for home. RESULTS A total of 416 patients (age 71.7 ± 14.1 yr, 52.6% male, body mass index 23.6 ± 5.2 kg/m2) were included. At the first delivery of ONS, 44.5% (n = 185) of patients had no medical prescription for the supplements, and 82.7% (n = 344) had an NRS-2002 score ≥3. Out of 207 patients discharged for home, only 24.2% (n = 50) had an adequate homecare ONS prescription and 68% (n = 141) had a NRS-2002 score ≥3. One month after discharge for home, 76% (n = 29) were still taking ONS. CONCLUSIONS In our survey, only few patients receiving ONS during the hospital stay had a medical prescription for ONS during the hospitalisation and at discharge for home. For most patients receiving ONS during hospitalisation and at discharge for home, an NRS-2002 score of ≥3 was present. If a medical prescription was provided, ONS were generally continued one month after discharge for home. CLINICAL TRIAL REGISTRATION NUMBER NCT02476110.

Erratum to: Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?

Background: Methods to calculate energy expenditure (EE) based on CO2 measurements (EEVCO2) have been proposed as a surrogate to indirect calorimetry. This study aimed at evaluating whether EEVCO2 could be considered as an alternative to EE measured by indirect calorimetry. Methods: Indirect calorimetry measurements conducted for clinical purposes on 278 mechanically ventilated ICU patients were retrospectively analyzed. EEVCO2 was calculated by a converted Weir’s equation using CO2 consumption (VCO2) measured by indirect calorimetry and assumed respiratory quotients (RQ): 0.85 (EEVCO2_0.85) and food quotient (FQ; EEVCO2_FQ). Mean calculated EEVCO2 and measured EE were compared by paired t test. Accuracy of EEVCO2 was evaluated according to the clinically relevant standard of 5% accuracy rate to the measured EE, and the more general standard of 10% accuracy rate. The effects of the timing of measurement (before or after the 7th ICU day) and energy provision rates (<90 or ≥90% of EE) on 5% accuracy rates were also analyzed (chi-square tests). Results: Mean biases for EEVCO2_0.85 and EEVCO2_FQ were -21 and -48 kcal/d (p = 0.04 and 0.00, respectively), and 10% accuracy rates were 77.7 and 77.3%, respectively. However, 5% accuracy rates were 46.0 and 46.4%, respectively. Accuracy rates were not affected by the timing of the measurement, or the energy provision rates at the time of measurements. Conclusions: Calculated EE based on CO2 measurement was not sufficiently accurate to consider the results as an alternative to measured EE by indirect calorimetry. Therefore, EE measured by indirect calorimetry remains as the gold standard to guide nutrition therapy.

Energy expenditure (EE) in mechanically ventilated patients: espen equation using different body weights (BW) vs. indirect calorimetry (IC)

IC is the reference method to measure EE, but is not available in every healthcare center. ESPEN guidelines recommend using a predictive equation based on the BW before acute illness in case of fluid retention, but the accuracy of this BW is questionable.

SUN-PP069: Energy Expenditure (EE) in Mechanically Ventilated Patients: Espen Equation Using Different Body Weights (BW) Vs. Indirect Calorimetry (IC)

Methods All mechanically ventilated patients staying >72h in ICU, with Fi02 < 60%, PEEP < 9cmH2O, no pulmonary fistula or lung multi-resistant bacteria were included and had IC measurement. We calculated EE with the ESPEN equation (20-25 kcal/kg acute phase and 25-30 kcal/kg post-acute phase), using several BW: anamnestic (BWAN), measured (BWMES), adjusted for water balance (BWADJ) and ideal BW calculated for a body mass index of 22.5 and 25 kg/m. Results are presented as mean ± SD. Calculated EE was compared to EE measured by IC, with ANOVA repeated measure and Bonferroni posthoc test, as well as Bland-Altman analysis.

PP013-SUN DIARRHEA IN THE INTENSIVE CARE UNIT (ICU): RESPECTIVE CONTRIBUTION OF FEEDING AND ANTIBIOTICS

PP012-SUN Outstanding abstract ASSOCIATION BETWEEN PLASMA AND ERYTHROCYTE COPPER LEVELS, AND ANTIOXIDANT STATUS IN CRITICALLY ILL PATIENTS WITH SYSTEMIC INFLAMMATORY RESPONSE SYNDROME E.M. Planells1, L. Saez2, J. Molina-Lopez2, D. Florea2, M. Navarro2, B. Quintero3, C. Cabeza3, A. Perez de la Cruz4, M. Rodriguez Elvira5. 1Physiology, University of Granada, Otura, Granada, 2Physiology, 3Phisico-Chemical, University of Granada, 4Unidad Nutricion y Dietetica, 5Unidad Cuidados Intensivos, Hospital Virgen de las Nieves, Granada, Spain