Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where S. J. Ireland is active.

Publication


Featured researches published by S. J. Ireland.


Biochemical Pharmacology | 1992

Substituted imidazo[1,2-b]pyridazines: New compounds with activity at central and peripheral benzodiazepine receptors

Les P. Davies; G. B. Barlin; S. J. Ireland; Maria M.L. Ngu

A large range of substituted imidazo[1,2-b]pyridazines have been synthesized, and a number of potent ligands at central benzodiazepine (Bz) receptors on rat brain membranes have been identified in initial binding screens using [3H]diazepam. For those tested more extensively, binding studies conducted in the presence and absence of gamma-aminobutyric acid suggest that they were full receptor agonists. Some preliminary evidence was found suggesting some species selectivity, i.e. several of the compounds were more active in in vivo tests in rats than in mice. The agonist activity of these 2-phenyl (and substituted phenyl) imidazo[1,2-b]pyridazines is consistent with the model of Bz receptor ligands as proposed by Fryer [Raven Press, 1983, pp. 7-20]. Several compounds were identified which had more selective activity at peripheral-type (mitochondrial) Bz binding sites. Thus, substituted imidazo[1,2-b]pyridazines represent yet another class of low molecular mass compounds which have activity at Bz receptor sites.


Australian Journal of Chemistry | 1992

Imidazo[1,2-b]pyridazines. XII. Syntheses and Central Nervous System Activities of Some Substituted Imidazo[1,2-b]pyridazines and Related Imidazo[1,2-a]pyridines, Imidazo[1,2-a]pyrimidines and Imidazo[1,2-a]pyrazines

G. B. Barlin; Les P. Davies; S. J. Ireland; M. M. L. Ngu; Jk Zhang


Australian Journal of Chemistry | 1992

Imidazo[1,2-b]pyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo[1,2-b]pyridazines

G. B. Barlin; Les P. Davies; S. J. Ireland; M. M. L. Ngu; Jk Zhang


Australian Journal of Chemistry | 1994

Imidazo[1,2-b]pyridazines. XV. Synthesis and Anxiolytic Activity of Some 3-(Benzamidomethyl and fluorobenzamidomethyl)-6-(fluoro, chloro and methylthio)-2-(4-tolyl and 3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines

G. B. Barlin; Les P. Davies; B. Glenn; P. W. Harrison; S. J. Ireland


Australian Journal of Chemistry | 1996

Imidazo[1,2-b]Pyridazines. XXI. Syntheses of Some 3-Acylaminomethyl-6-(chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio)-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β-naphthyl and styryl)imidazo[1,2-b]pyridazines and Their Interaction With Central and Peripheral-Type Benzodiazepine Receptors

G. B. Barlin; Les P. Davies; P. W. Harrison; S. J. Ireland; A. C. Willis


Australian Journal of Chemistry | 1994

Potential Antimalarials. XXI. Mannich Base Derivatives of 4-[7-Chloro(and 7-trifluoromethyl)quinolin-4-ylamino]phenols

G. B. Barlin; S. J. Ireland; T. M. T. Nguyen; B. Kotecka; K. H. Rieckmann


Australian Journal of Chemistry | 1993

Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and trifluoromethyl)quinolin-4-ylamino]phenol

G. B. Barlin; S. J. Ireland; T. M. T. Nguyen; B. Kotecka; K. H. Rieckmann


Australian Journal of Chemistry | 1992

Imidazo[1,2-b]pyridazines. XIII. Syntheses and Central Nervous System Activities of Some 2-Benzyl(phenethyl, biphenyl-4'-yl, 6'-methylnaphthalen-2'-yl, t-Butyl and cyclohexyl)-3-methoxy(acylaminomethyl and dimethylaminomethyl)-6-(variously substituted)imidazo[1,2-b]pyridazines

G. B. Barlin; Les P. Davies; S. J. Ireland; Jk Zhang


Australian Journal of Chemistry | 1989

Imidazo[1,2-b]Pyridazines. VI. Syntheses and Central Nervous System Activities of Some 6-(Alkoxy- and Methylthio-phenoxy and Methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)Imidazo[1,2-b]pyridazines

G. B. Barlin; Les P. Davies; S. J. Ireland; M. M. L. Ngu


Australian Journal of Chemistry | 1997

Imidazo[1,2-b]pyridazines. XXII. Syntheses of Some 2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines and Their Interaction with Central and Mitochondrial (Peripheral-Type) Benzodiazepine Receptors

G. B. Barlin; Les P. Davies; S. J. Ireland; Maria Ngu-Schwemlein

Collaboration


Dive into the S. J. Ireland's collaboration.

Top Co-Authors

Avatar

G. B. Barlin

Australian National University

View shared research outputs
Top Co-Authors

Avatar

Les P. Davies

Australian National University

View shared research outputs
Top Co-Authors

Avatar

Maria M.L. Ngu

Australian National University

View shared research outputs
Top Co-Authors

Avatar

Maria Ngu-Schwemlein

Winston-Salem State University

View shared research outputs
Researchain Logo
Decentralizing Knowledge