S. K. Dutta Chowdhury

Studies on β-Enaminonitriles: A one-pot Regiospecific Synthesis of Polysubstituted 3,4-Dihydro-2(1H)-Pyridones

Abstract Reaction of α, β-unsaturated acid chlorides with primary enaminonitriles in presence of triethylamine affords, under very mild conditions, a simple and highly efficient regiospecific synthesis of polysubstituted 3,4-dihydro-2(1H)-pyridones.

Synthesis of Novel 3,5‐Disubstituted‐4‐isothiazolecarbonitriles

Abstract α‐Cyano‐β‐enaminones, obtained by regioselective acylation of β‐enaminonitriles, were smoothly converted to thiones which on oxidative cyclization afforded 3,5‐disubstituted‐4‐isothiazolecarbonitriles in good to excellent yields.

A short and expeditious regiospecific synthesis of novel pyrazoles

α-Cyano-β-enaminones, obtained by regioselective acylation of β-aminocrotononitrile, are smoothly and regiospecifically converted into substituted pyrazoles in good to excellent yields.

Synthesis of substituted isoxazolones and isoxazoles from cyanoenaminones

α-Cyano-β-enaminones, obtained by regioselective acylation of β-aminocrotononitrile, are smoothly and regiospecifically converted into substituted 5-isoxazolones, which on alkaline hydrolysis afford 4-acyl-3-substituted-5-hydroxyisoxazoles in good to excellent yields.