S. Maddaluno
University of Naples Federico II
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Publication
Featured researches published by S. Maddaluno.
Journal of Paediatrics and Child Health | 2012
Claudio Veropalumbo; Ennio Del Giudice; Gabriella Esposito; S. Maddaluno; Lucia Ruggiero; Pietro Vajro
The aim of this study was to call the attention to the often disregarded message that hypertransaminasemia may be a marker of both liver and muscle diseases by presenting personal case reports and a systematic literature review. Three male children (mean age 5.7 years) were inappropriately addressed, during the last 12 months, to our paediatric liver unit for diagnostic work‐up of a chronic hypertransaminasemia of unknown origin. In one of them, a liver biopsy had already been performed. On admission, physical examination, evaluation of serum levels of creatine kinase, and dystrophin genetic testing finally led to a diagnosis of muscular dystrophy. One hundred fourteen similar cases, 21 with unnecessary liver biopsy, were found by Medline search. Expensive and invasive tests planned to investigate liver diseases should be postponed until alternative sources of increased serum aminotransferases, primarily myopathic injury, have been excluded.
World Journal of Pediatrics | 2013
Pietro Vajro; Claudio Veropalumbo; S. Maddaluno; Mariacarolina Salerno; Giancarlo Parenti; Claudio Pignata
BackgroundAt present, therapy of children with chronic hepatitis B and C is still based on few drugs, all burdened by a series of side-effects, unsatisfactory serum conversion rates, and/or drug-resistance. Moreover, selection of subjects to treat with conventional therapies is not univocal, especially during the pediatric age when the disease course is often mild with significant spontaneous seroconversion rate. Our review deals with pros and cons points when a physician decides to design a drug therapy for a child with chronic viral hepatitis, and different possible therapeutic opportunities.MethodsA literature search was performed through PubMed. The newest articles, reviews, systematic reviews, and guidelines were included in this review.ResultsThe management of children with viral hepatitis is still controversial over whom and when to treat and the use of drug(s). Novel therapeutic strategies have been evaluated only in clinical and preclinical trials involving, for instance, “therapeutic” vaccines. The data on safety and effectiveness of new drugs are also reviewed.ConclusionThe results of reported studies confirmed that at least some of the new drugs, with greater efficacy and/or minor side-effects, will be used clinically.
Transplant Infectious Disease | 2009
Pietro Vajro; Etienne Sokal; S. Maddaluno; M. Esposito; F. Caranci; G. Capuano; M. Caropreso; S. Lenta
Abstract: Brain abscesses are a rare, severe complication of orthotopic liver transplantation (OLT). They are almost exclusively due to fungi, Nocardia, or Toxoplasma, and usually occur within months of surgery. Here we report the case of an adolescent who developed a brain abscess due to Klebsiella pneumoniae 11.5 years after OLT. Fever was absent and laboratory parameters were not indicative of infectious disease, and therefore the diagnosis of a central nervous system neoplasm was considered. Subsequent magnetic resonance imaging and spectroscopy led to a diagnosis of a brain abscess, and to prompt appropriate antibiotic treatment. This case shows that K. pneumoniae may cause a brain abscess long after liver transplantation. The appearance of neurological symptoms should alert clinicians to consider a brain abscess even in the absence of overt clinical/laboratory signs of inflammation, which may be blunted by chronic immunosuppression.
World Journal of Gastroenterology | 2013
Pietro Vajro; S. Maddaluno; Claudio Veropalumbo
Journal of the Pediatric Infectious Diseases Society | 2015
Francesco Raimondi; Claudio Veropalumbo; Clara Coppola; S. Maddaluno; Teresa Ferrara; Giancarlo Cangiano; Letizia Capasso
Journal of Pediatric Gastroenterology and Nutrition | 2013
Pietro Vajro; Riccardo Campanile; M. Caropreso; Carmelo Piscopo; S. Maddaluno; Giuseppe Castaldo
Journal of Pediatric Gastroenterology and Nutrition | 2010
M. Caropreso; Riccardo Campanile; S. Maddaluno; Claudio Veropalumbo; Carmelo Piscopo; Giuseppe Castaldo; Pietro Vajro
Digestive and Liver Disease | 2012
Maria Sangermano; R. D'Aniello; Giulia Paolella; Claudio Veropalumbo; S. Maddaluno; Pietro Vajro
Digestive and Liver Disease | 2012
Giulia Paolella; Giuseppe Giordano; Claudio Veropalumbo; S. Maddaluno; Pietro Vajro
Digestive and Liver Disease | 2012
Claudio Veropalumbo; S. Maddaluno; Giulia Paolella; I. De Micco; L. Ferrante; N. Di Cosmo; Pietro Vajro