S. N. Sawhney

Potent antiinflammatory 3-thiazole-4(5)-acetic acids of 1,2-benzisothiazole

Abstract A number of 1,2-benzisothiazole derivatives, having 2-thiazolyl-4(5)-acetic acid moiety attached to position-3 of 1,2-benzisothiazole nucleus, were prepared and evaluated as antiinflammatory agents. Some of these were found to possess excellent level of antiinflammatory activity in carrageenin-induced rat paw edema assay.

Synthesis and antiflammatory activity of some 3-heterocycle-1,2-benzisothiazoles

Abstract A number o 3-heterocyclyl-1,2-benzisothiazoles, having 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole ring systems attached to position-3 of 1,2-benzisothiazole nucleus, were prepared and evaluated as antiinflammatory agents.

A NEW SYNTHESIS OF 2-ARYLBENZOTHIAZOLES FROM 1,2,3-BENZODITHIAZOLE-2-OXIDES

Abstract The reaction of 6-substituted-1,2,3-benzodithiazole-2-oxides (3a-3d) with aromatic aldehydes, carboxylic acids, and their chlorides in the presence of an organic base provides a new method for the synthesis of 6-substituted-2-arylbenzothiazoles (4a-4d) without involving the preparation of intermediate 2-aminobenzenethiols.