S. Premalatha

Cutaneous Metastasis from Carcinoma Cervix

A ^.S-year-t)ld South Indian woman, mother of seven children, was diagnosed in 1979 as having squamous cell i.ircinoma of the cervix, staĵ e IMB, and was treated with external and intracavitary radiation. In early 1983, she sought an O[>inion regarding an 8 X 5-cm, pigmented, indurated, painless plaque on the posterior aspect of her left thigh present for 6 months (Fig. 1). All routine investigations were normal. A biopsy specimen w.is laken from the pigmented plaque and sections stained with HivE (Fig. 2). The epidermis showed hyperkeratosis, irregular acanthosis, and increased pigment in the basal cell layer. In ihe dermis, atypical squ.imous cells with hypcrthromatic nuclei and numerous mitotic figures were found extending into the subcutis, suggestive of metastatic squamous cell ( arc inoma [Fig. 3). A second course of irradiation over the plaque did not produce any improvement in the size of the plaque. As her general condition improved with supportive measures, she was discharged to her home.

Periumbilical perforating Pseudoxanthoma elasticum

Chez une femme multipare de 50 ans presentant une lesion abdominale depuis 12 ans. La lesion noirâtre augmente de taille progressivement avec inflammations douloureuses. Etude anatomopathologique

Cerebriform tongue—a clinical sign in pemphigus vegetans

Ten cases of pemphigus vegetans of Neumann type are reported. Six of these showed clinically distinctive changes in the tongue for which the term cerebriform tongue is proposed. Histological examination of the tongue showed typical features of pemphigus vegetans.

Lawrence‐Seip syndrome

A case is reported showing insulin resistant diabetes mellitus with acanthosis nigricans, clitoral hypertrophy and the typical facies of the Lawrence‐Seip syndrome.

Dermatoglyphics in Vitiligo

One hundred probands of vitiligo were studied for palmar dermatoglyphics, both qualitatively and quantitatively, and were compared with those of 100 phenotypically normal control subjects. Ulnar loop pattern was the most common digital pattern observed in both probands and controls. An increased incidence of whorls and arches in men and women probands, respectively, was found to be statistically significant when compared with those of controls. Simian crease and Sydney line also have been observed in the present study, which has not been previously reported. A statistically highly significant reduction has been observed in total finger ridge count (TFRC) and a-b ridge count in both sexes of vitiligo cases when compared with those of controls. No significant changes was observed in the values of atd angle and position of axial triradius.

Acanthosis palmaris in a patient with bullous pemphigoid

Acanthosis palmaris, a recently described dermatologic entity, is often associated with internal malignancy. We report the development, disappearance, and reappearance of this condition in a patient with bullous pemphigoid. Relevant screening tests did not reveal any internal malignant neoplasm. The significance of the appearance and disappearance of the condition is discussed.

Nocardiosis. Two case reports

Two cases of Nocardiosis involving unusual sites are reported. The diagnostic value of the appearance of the organism in section is emphasized. The remarkable tolerance to sulphonamide drugs is noted.

Deep angiomatous nevus with ipsilateral cataract

A woman reported to the dermatology department with a skin lesion over the left side of the forehead that had been present since birth. The lesion was asymptomatic until age 27 years. For tbe past 3 years there was a consistent increase in tbe size of tbe lesion with multiple nodules developing on the surface. Tbe patient also complained of progressive dimness of vision in tbe ieft eye during tbe past 3 years. Tbere was no bistory of seizures or beadacbe, no evidence of increased intracranial tension, and no history of gastrointestinal and cardiovascular symptoms. Family bistory was not significant.