S. Syed Shafi

Studies on the Kinetics of Tetraethylammonium Bromochromate Oxidation of Some Meta- and Para-Substituted Benzyl Alcohols in Non-Aqueous Media

Abstract Tetraethylammonium bromochromate (TEABC) oxidation of 18 meta- and para-substituted benzyl alcohols (BnOH) in dimethylsulphoxide (DMSO) leads to the formation of corresponding aldehydes. The reaction is first order each in TEABC and the alcohols. The reaction is catalyzed by hydrogen ions. The hydrogen ion dependence has the form: kobs=a+b[H+]. The oxidation of αα´-dideuterio benzyl alcohol exhibited a substantial primary kinetic isotope effect (kH/kD=5.71 at 303 K). Oxidation of benzyl alcohol was studied in 17 different organic solvents. The solvent effect has been analyzed using Kamlets and Swains multi parametric equation. A correlation of data with Kamlet–Taft solvatochromic parameters (α, β, π*) suggests that the specific solute-solvent interactions play a major role in governing the reactivity. A mechanism involving a hydride ion transfer via chromate ester is proposed.

Thiophene and benzodioxole appended thiazolyl-pyrazoline compounds: Microwave assisted synthesis, antimicrobial and molecular docking studies.

A novel series of thiophene and benzodioxole appended thiazolyl-pyrazoline derivatives have been designed, synthesized and evaluated against different bacteria and fungi. The antimicrobial activity of the synthesized compounds were screened using MIC method and were proved synthesized compounds 7o, 7r and 7t to show good antimicrobial activity against bacteria and fungi. In silico molecular docking studies revealed that all the synthesized molecules showed good binding energy toward the target receptor DNA topoisomerase IV, ranging from -10.42 to -11.66 kcal/mol.

Kinetics and Mechanism of Oxidation of Aromatic Aldehydes by Imidazolium Dichromate in Aqueous Acetic Acid Medium

The kinetics of oxidation of benzaldehyde (BA) and para-substituted benzaldehydes by imidazolium dichromate (IDC) has been studied in aqueous acetic acid medium in the presence of perchloric acid. The reaction is first order each in [IDC], [Substrate] and [H

Synthesis of Various Polyaniline / Clay Nanocomposites Derived from Aniline and Substituted Aniline Derivatives by Mechanochemical Intercalation Method

Polyaniline clay nanocomposite can be prepared by mechano-chemical method in which intercalation of anilinium ion into the clay lattices accomplished by mechanical grinding of sodium montmorillonite (Na