Sa Adebisi

Pattern Of Drug Induced Hyperuricaemia In Nigerians With Pulmonary Tuberculosis

Thirty-one patients with newly diagnosed pulmonary tuberculosis were longitudinally studied between January 1997 and June 1998; each for 6 months to determine the pattern of drug induced hyperuricaemia. Biochemical indices determined were serum urate and 24 hours urinary output of urate, before and during treatment with antituberculosis therapy. At the end of the 1st and 2nd months of therapy 16 (51.6%) and 15 (48.4%) of the patients respectively were hyperuricaemic. These were statistically significant when compared with the pretreatment data with P value of 0.001 and 0.002 respectively. At the end of the 6th months there was no significant difference in the incidence of hyperuricaemia observed as compared with the pretreatment level. The pretreatment mean 24 hours urinary urate output was 4.83 mmol/24 hours, the corresponding values at the end of the 1st and second months of treatment was 3.38 mmol/24 hour and 3.74mmol/24 hours. These value are significantly lower than the pretreatment value with P value of P (Af. J. of Clinical and Experimental Microbiology: 2002 3(1): 17-20)