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Dive into the research topics where Sa Yasin is active.

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Featured researches published by Sa Yasin.


Arthritis & Rheumatism | 2016

Muscle biopsy in combination with myositis-specific autoantibodies aids prediction of outcomes in juvenile dermatomyositis.

Claire T Deakin; Sa Yasin; Stefania Simou; Katie Arnold; Sarah L. Tansley; Zoe Betteridge; Neil McHugh; Hemlata Varsani; Janice L. Holton; Ts Jacques; Clarissa Pilkington; Kiran Nistala; Lr Wedderburn

Juvenile dermatomyositis (DM) is a rare and severe autoimmune condition characterized by rash and proximal muscle weakness. While some patients respond to standard treatment, others do not. This study was carried out to investigate whether histopathologic findings and myositis‐specific autoantibodies (MSAs) have prognostic significance in juvenile DM.


Pediatric Rheumatology | 2014

How do tissue infiltrating B cells and plasma cells correlate with other inflammatory features in muscle tissue from patients with JDM

Erdal Sag; Sa Yasin; Katie Arnold; Janice L. Holton; Ts Jacques; Lucy R. Wedderburn

The International Juvenile Dermatomyositis (JDM) Biopsy Consensus Group has previously published and validated a scoring tool for assessment of the severity of pathological change in biopsy specimens from patients with suspected or proven JDM. This tool assesses histological features characteristic of JDM, organised into four domains (inflammatory, vascular, muscle fibre and connective tissue). The score tool includes the assessment of CD3+ and CD68+ inflammatory cells. Given that JDM is a disease characterised by production of autoantibodies and some patients respond to anti-B cell therapy we hypothesise that B cells play an important role in the pathogenesis of the disease.


Pediatric Rheumatology | 2017

Effective induction therapy for anti-SRP associated myositis in childhood: A small case series and review of the literature

E. L. Binns; Elena Moraitis; S Maillard; Sarah L. Tansley; Neil McHugh; Ts Jacques; Lr Wedderburn; Clarissa Pilkington; Sa Yasin; K. Nistala


In: (pp. pp. 41-42). (2010) | 2010

Subependymal Giant Cell Astrocytoma (SEGA) cells respond to rapamycin in vitro

Sa Yasin; William Harkness; Jh Cross; Nr Cohen; Ts Jacques


In: (Proceedings) 117th Meeting of the British-Neuropathological-Society. (pp. p. 27). WILEY-BLACKWELL (2016) | 2016

Histological subtypes of juvenile dermatomyositis

Peter W. Schutz; Sa Yasin; Claire T Deakin; Ts Jacques; Janice L. Holton; Lr Wedderburn


Neuromuscular Disorders | 2015

How do tissue infiltrating B cells correlate with other inflammatory features in muscle tissue from patients with JDM and their clinical parameters

E. Sag; Sa Yasin; Katie Arnold; Janice L. Holton; Ts Jacques; Lucy R. Wedderburn


In: (Proceedings) Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology. (pp. p. 44). OXFORD UNIV PRESS (2015) | 2015

AN INTEGRATIVE ANALYTICAL APPROACH TO SUBPHENOTYPING OF JUVENILE DERMATOMYOSITIS

Claire T Deakin; Sa Yasin; Katie Arnold; Sarah L. Tansley; Zoe Betteridge; Neil McHugh; Janice L. Holton; Ts Jacques; Lr Wedderburn


In: (Proceedings) 8th Joint Meeting of the British-Division of the International-Academy-of-Pathology and the Pathological-Society-of-Great-Britain-and-Ireland. (pp. S13-S13). WILEY-BLACKWELL (2015) | 2015

Gene Network Analysis Reveals a Novel Pathological Cell Type in Paediatric Focal Cortical Dysplasia

F Scerif; Picker; Sa Yasin; A Alahdal; Alex Virasami; William Harkness; M Tisdall; F Guillemot; Sml Paine; Jh Cross; Ts Jacques


In: (Proceedings) 116th Meeting of the British-Neuropathological-Society. (pp. pp. 46-47). WILEY-BLACKWELL (2015) | 2015

B cells correlate with histological and clinical features of muscle disease in patients with juvenile dermatomyositis

Sa Yasin; Erdal Sag; Katie Arnold; C Sawali; Janice L. Holton; Ts Jacques; Lr Wedderburn


In: (Proceedings) 116th Meeting of the British-Neuropathological-Society. (pp. pp. 16-17). WILEY-BLACKWELL (2015) | 2015

Identifying novel cell types in focal cortical dysplasia by gene network analysis

F Scerif; Picker; Sa Yasin; Alex Virasami; A Alahdal; William Harkness; M Tisdall; F Guillemot; Sml Paine; Jh Cross; Ts Jacques

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Ts Jacques

Great Ormond Street Hospital for Children NHS Foundation Trust

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William Harkness

Great Ormond Street Hospital

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Jh Cross

Great Ormond Street Hospital

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Janice L. Holton

UCL Institute of Neurology

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Katie Arnold

University College London

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Lr Wedderburn

Great Ormond Street Hospital

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Brian Harding

Children's Hospital of Philadelphia

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K Miller

Great Ormond Street Hospital

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Sml Paine

UCL Institute of Child Health

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Claire T Deakin

University College London

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