Sabine Lutz

Cyclodextrins as chiral stationary phases in capillary gas chromatography. Part III: Hexakis(3-O-acetyl-2,6-di-O-pentyl)-α-cyclodextrin†

The properties of hexakis(3-O-acetyl-2,6-di-O-pentyl)-α-cyclodextrin as a chiral stationary phase for capillary gas chromatography are described. For the first time the enantiomers of a series of different lactones are separated and their order of elution is assigned. Moreover, the enantiomers of trifluoroacetylated aldols and amino alcohols, the cyclic carbonates of 1,2-diols, 1,3-diols, O-alkylated glycerols, and some chiral pharmaceuticals are also separated on the new chiral phase. The modified α-cyclodextrin is stable above 200°C.

Improved gas chromatographic separation of enantiomeric carbohydrate derivatives using a new chiral stationary phase

Abstract Pentylated cyclomaltohexaose (α-cyclodextrin) can be used as a chiral stationary phase for capillary g.l.c. in the range 40° to > 200°. Strong enantioselective molecular interactions are observed towards trifluoroacetylated carbohydrates, methyl glycosides, 1,4- and 1,5-anhydroalditols, polyols, and polyhydroxy acid methyl esters. Base-line resolution of enantiomers is achieved after only a few minutes.

Enantiomer separation of chiral barbiturates and of α-lipoic acid by capillary gas chromatography with modified cyclodextrins as chiral stationary phases

In this work, improved resolutions of racemic barbiturates and the first separation of the enantiomers of α-lipoic acid are demonstrated

Enantiomer separation of acyloins and cyanohydrins by enantioselective capillary gas chromatography

Abstract Enantioselective capillary gas chromatography was used to separate the isopropylurethane derivatives of α-hydroxyketones (acyloins) and of cyanohydrins. The investigation of acyloin samples with defined enantiomeric composition proved that derivatization proceeds without racemization.

Enantioselective Capillary Gas Chromatography with Modified Cyclodextrins as Chiral Stationary Phases

Hydrophobic derivatives of cyclodextrins are perfectly suited as chiral stationary phases for capillary gas chromatography. Per-penty-lated and partially pentylated and acetylated α- and β- cyclodextrins can be used to separate the enantiomers of a great variety of chiral molecules, thus providing a powerful tool for stereochemical analysis of natural compounds, flavour constituents, pheromones, pharmaceuticals and products from enantioselective chemical reactions.