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Dive into the research topics where Sabry H. H. Younes is active.

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Featured researches published by Sabry H. H. Younes.


Acta Crystallographica Section E-structure Reports Online | 2013

3-Amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile

Mehmet Akkurt; Alan R. Kennedy; Shaaban K. Mohamed; Sabry H. H. Younes; Gary J. Miller

In the title compound, C20H14N2O, the phenyl ring is almost normal to the naphthalene ring system with a dihedral angle of 86.72 (9)°. The 4H-pyran ring fused with the naphthalene ring system has a boat conformation. In the crystal, molecules are linked into a helical supramolecular chain along the b axis via N—H⋯N hydrogen bonds. The chains are consolidated into a three-dimensional architecture by C—H⋯π interactions.


Archiv Der Pharmazie | 2013

Studies on Organophosphorus Compounds. Part 1: Synthesis and In Vitro Antimicrobial Activity of Some New Pyrimido[5′,4′:5,6]pyrano[2,3-d][1,3,2]thiazaphosphinine Compounds

Sabry H. H. Younes; Shaaban K. Mohamed; Mustafa R. Albayati

2,4‐Bis(4‐methoxyphenyl)‐1,3,2,4‐dithiadiphosphetane‐2,4‐disulfide (Lawessons reagent, LR) reacted with pyrano[2,3‐d]pyrimidine‐2,4‐(1H,3H)‐dione derivatives in boiling acetonitrile to afford various pyrimido[5′,4′:5,6]pyrano[2,3‐d][1,3,2]thiazaphosphinine derivatives. The structures of the target compounds were characterized by elemental analysis and spectral data. The biological activities of all synthesized compounds were tested against various microorganisms by the disk diffusion method. In general, the newly synthesized compounds showed good inhibitory effects against most of the applied microorganisms.


Chemical Science | 2013

Functionalization of Ibuprofen Core Structure Compound:Synthesis of New Potential Chemotherapeutic Agents Incorporating Ibuprofen Substructure

Shaaban K. Mohamed; Mustafa R. Albayati; Sabry H. H. Younes; Mohammed G Abed-Alkareem

New series of potential biologically active agents have been synthesized by functionalization of ibuprofen core structure involving hydrazidic, heterocyclic, quinone and indole containing motifs. The targeted products have been achieved in a very good yield (average 75%) under conventional heat and irradiation conditions. All compounds have been characterized by IR, 1H-NMR, 13C-NMR and Mass spectra.


Acta Crystallographica Section E-structure Reports Online | 2012

2-Amino-4-(4-meth­oxy­phen­yl)-5-oxo-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile 1,4-dioxane hemisolvate

Shaaban K. Mohamed; Mehmet Akkurt; Muhammad Nawaz Tahir; Antar A. Abdelhamid; Sabry H. H. Younes

In the crystal structure of the title compound, C17H16N2O3·0.5C4H8O2, pairs of N—H⋯N hydrogen bonds link molecules into dimers with R 2 2(12) motifs, which are connected by N—H⋯O hydrogen bonds, forming a supramolecular array in the ab plane. The 1,4-dioxane ring, which lies about an inversion center, adopts a chair conformation.


Phytochemical Analysis | 2018

Identification of some Bioactive Metabolites in a Fractionated Methanol Extract from Ipomoea aquatica (Aerial Parts) through TLC, HPLC, UPLC-ESI-QTOF-MS and LC-SPE-NMR Fingerprints Analyses

Mahmoud Hefny Gad; Emmy Tuenter; Nagwa M. Elsawi; Sabry H. H. Younes; El-Mewafy El-Ghadban; Kristiaan Demeyer; Luc Pieters; Yvan Vander Heyden; Debby Mangelings

INTRODUCTION The plant species Ipomoea aquatica contains various bioactive constituents, e.g. phenols and flavonoids, which have several medical uses. All previous studies were executed in Asia; however, no reports are available from Africa, and the secondary metabolites of this plant species from Africa are still unknown. OBJECTIVE The present study aims finding suitable conditions to identify the bioactive compounds from different fractions. METHODOLOGY Chromatographic fingerprint profiles of different fractions were developed using high-performance liquid chromatography (HPLC) and then these conditions were transferred to thin-layer chromatography (TLC). Subsequently, the chemical structure of some bioactive compounds was elucidated using ultra-performance liquid chromatography-quadrupole time of flight-tandem mass spectrometry (UPLC-QTOF-MS) and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) spectroscopy. RESULTS The HPLC fingerprints, developed on two coupled Chromolith RP-18e columns, using a gradient mobile phase (methanol/water/trifluoroacetic acid, 5:95:0.05, v/v/v), showed more peaks than the TLC profile. The TLC fingerprint allows the identification of the types of chemical constituents, e.g. flavonoids. Two flavonoids (nicotiflorin and ramnazin-3-O-rutinoside) and two phenolic compounds (dihydroxybenzoic acid pentoside and di-pentoside) were tentatively identified by QTOF-MS, while NMR confirmed the structure of rutin and nicotiflorin. CONCLUSION The HPLC and TLC results showed that HPLC fingerprints give more and better separated peaks, but TLC helped in determining the class of the active compounds in some fractions. Bioactive constituents were identified as well using MS and NMR analyses. Two flavonoids and two phenolic compounds were tentatively identified in this species for the first time, to the best of our knowledge. Copyright


Acta Crystallographica Section E: Crystallographic Communications | 2015

Crystal structure of [(E)-({2-[3-(2-{(1E)-[(carbamo­thioyl­amino)­imino]­meth­yl}phen­oxy)prop­oxy]phen­yl}methyl­idene)amino]­thio­urea with an unknown solvate

Joel T. Mague; Shaaban K. Mohamed; Mehmet Akkurt; Sabry H. H. Younes; Mustafa R. Albayati

The title molecule, C19H22N6O2S2, has crystallographically imposed C 2 symmetry, with the central C atom lying on the rotation axis. The O—C—C—C torsion angle for the central chain is −59.22 (16)° and the dihedral angle between the planes of the benzene rings is 75.20 (7)°. In the crystal, N—H⋯O and N—H⋯S interactions link the molecules, forming a three-dimensional network encompassing channels running parallel to the c axis, which account for about 20% of the unit-cell volume. The contribution to the scattering from the highly disordered solvent molecules in these channels was removed with the SQUEEZE routine [Spek (2015). Acta Cryst. C71, 9–18] in PLATON. The stated crystal data for M r, μ etc. do not take these into account.


Acta Crystallographica Section E: Crystallographic Communications | 2015

Crystal structure of 3-amino-1-(4-chlorophenyl)-1H-benzo[f]chromene-2-carbonitrile

Mehmet Akkurt; Peter N. Horton; Shaaban K. Mohamed; Sabry H. H. Younes; Mustafa R. Albayati

In the title compound, C20H13ClN2O, the chlorobenzene ring is almost perpendicular to the mean plane of the naphthalene ring system, making a dihedral angle of 81.26 (8)°. The 4H-pyran ring fused with the naphthalene ring system has a flattened boat conformation. In the crystal, N—H⋯N hydrogen bonds generate chains along the b-axis direction. Further N—H⋯N hydrogen bonds link these chains into sheets parallel to (010). The crystal packing also features C—H⋯π interactions. The crystal studied was an inversion twin with a 0.557 (16):0.443 (16) domain ratio.


Acta Crystallographica Section E-structure Reports Online | 2013

2-(4-Oxo-3-phenyl-1,3-thia­zolidin-2-yl­idene)propanedi­nitrile

Mehmet Akkurt; Ahmed M. M. El-Saghier; Sabry H. H. Younes; Peter N. Horton; Mustafa R. Albayati

In the title compound, C12H7N3OS, the five-membered 1,3-thiazolidine ring is nearly planar [maximum deviation = 0.032 (2) Å] and makes a dihedral angle of 84.14 (9)° with the phenyl ring. In the crystal, molecules are linked by C—H⋯N hydrogen bonds into infinite chains along [-101]. C—H⋯π interactions contribute to the arrangement of the molecules into layers parallel to (101).


Acta Crystallographica Section E-structure Reports Online | 2012

4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one

Mehmet Akkurt; Alan R. Kennedy; Sabry H. H. Younes; Shaaban K. Mohamed; Antar A. Abdelhamid

In the title compound, C15H12N2O, the phenyl ring makes a dihedral angle of 32.45 (9)° with the benzene ring of the 1,5-benzodiazepin-2-one unit. The seven-membered ring adopts a boat conformation with the methylene group as the prow and the fused benzene-ring C atoms as the stern. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds generate R 2 2(8) loops. The dimers are further linked by C—H⋯O hydrogen bonds, so forming a column along the a-axis direction.


Acta Crystallographica Section E: Crystallographic Communications | 2015

Crystal structure of (5Z)-5-(2-hy-droxy-benzyl-idene)-1,3-thia-zolidine-2,4-dione.

Joel T. Mague; Shaaban K. Mohamed; Mehmet Akkurt; Sabry H. H. Younes; Mustafa R. Albayati

The title compound, C10H7NO3S, crystallizes with four independent molecules in the asymmetric unit with slightly different conformations; the dihedral angles between the six- and five-membered rings are 2.6 (1), 1.09 (9), 8.6 (1) and 6.2 (1)°. In the crystal, molecules are linked by O—H⋯O and N—H⋯O hydrogen bonds, forming sheets lying parallel to (101).

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Shaaban K. Mohamed

Manchester Metropolitan University

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Mustafa R. Albayati

Manchester Metropolitan University

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Peter N. Horton

University of Southampton

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Antar A. Abdelhamid

Manchester Metropolitan University

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Shaaban K. Mohamed

Manchester Metropolitan University

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Alan R. Kennedy

University of Strathclyde

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