Sadahide Ono

The first reported case of intestinal spirochaetosis in Japan

A 65‐year‐old Japanese male consulted Ozuchi Prefectural Hospital (Iwate, Japan) on 19 January 1994 complaining of weight loss. Cecal mucosal biopsy material, which was stained with hematoxylln‐eosin revealed a thick, basophllic fuzzy fringe covering the surface epithelium. Transmission and scanning electron microscopy observations demonstrated the presence of slightly wavy spirochaetes with tapered ends, which were attached to the surface epithelium of the colonlc mucosa via one of these ends. The patient did not display any clinical symptoms of Inflammatory bowel disease, and laboratory tests eliminated an Immunodeficiency condition. Thus, in the present case, the Intestinal spirochaetes appear to be harmless commensals. This paper presents the first reported case of Intestinal spirochaetosis fn Japan.

Portal venous gas associated with nonocclusive mesenteric infarction.

proved by the data of increased number of enterochromaffin cells and increased cell levels of 5-HT in celiac mucosa (12). The prolonged stimulation may trigger cell dysplasia and cancer transformation. Neuroendocrine tumors of the ileum are considered rare, but it is possible that a true association with the more common celiac disease exists, such as for adenocarcinoma of jejunum/ileum (4, 5). The question to be answered is if the association between carcinoid and celiac disease is greater than that expected by chance alone. To answer this question, it would be necessary to prospectively test for celiac disease all patients affected by neuroendocrine tumors of the gut.

A Case of Nonfunctioning Islet Cell Tumor Assessed Malignancy by Measuring the Nuclear DNA Content with a Flow Cytometer.

症例は60歳男性で集団検診にて肝機能異常を指摘され, 入院精査を受けたところ膵尾部に腫瘤が発見され, 膵尾部腫瘍の診断下に膵体尾部, 脾合併切除術を施行された.臨床的にホルモン過剰生産に伴う症状を呈さず, 組織化学検査でグリメリウス染色, クロモグラニン染色, NSE染色がいずれも陽性であり, 電顕にて内分泌顆粒が証明された.また, 血管侵襲像を認めたため非機能性膵島細胞癌と組織学的に診断された.Flow cytometryにより, 細胞核DNA量解析を行ったところ, 標本採取部位11か所中9か所でDI=1.36のaneuploidyを, 2か所でDI=1.36, 1.55の2クローンが混在していた.DNA ploidyからも病理組織診断が支持された.しかしながら, DNA合成期細胞の割合は小さく, 細胞の増殖能は低いことが示唆された.