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Sadahiko Iguchi

Kansas State University

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Publication

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Bulletin of the Chemical Society of Japan | 1981

Diisobutylaluminum 2,6-di-t-butyl-4-methylphenoxide. Novel stereoselective reducing agent for prostaglandin synthesis.

Sadahiko Iguchi; Hisao Nakai; Masaki Hayashi; Hisashi Yamamoto; Keiji Maruoka

In an effort to explore the selective reducing agents suitable for prostaglandin synthesis, diisobutylaluminum 2,6-di-t-butyl-4-methylphenoxide (1) is found to be among the best. Reduction of the C-15 ketone with 1 in toluene at −78 °C produced the desired 15S-alcohol in 95% yield with 92% stereoselectivity. The present procedure is suitable for the synthesis of prostaglandin derivatives and related polyfunctional natural products as shown in the conversion of PGE2 methyl ester to PGF2α methyl ester in 95% yield and 100% selectivity.

Chemical & Pharmaceutical Bulletin | 1992

Development of a Highly Cardioselective Ultra Short-Acting β-Blocker, ONO-1101

Sadahiko Iguchi; Hiroyuki Iwamura; Minoru Nishizaki; Akio Hayashi; Kazuhiko Senokuchi; Kaoru Kobayashi; Katsuhito Sakaki; Katsutoshi Hachiya; Yumiko Ichioka; Masanori Kawamura

Journal of Organic Chemistry | 1991

Stereoselective addition reactions of chiral N-benzylidene-p-toluenesulfinamides. Asymmetric syntheses of .beta.- and .gamma.-amino acids

Duy H. Hua; Shou Wu Miao; Jin Shan Chen; Sadahiko Iguchi

Journal of Medicinal Chemistry | 1992

Novel 5-HT3 antagonists. Isoquinolinones and 3-aryl-2-pyridones

Toshiaki Matsui; Tsuneyuki Sugiura; Hisao Nakai; Sadahiko Iguchi; Satoshi Shigeoka; Hideo Takada; Yoshihiko Odagaki; Yuhki Nagao; Yasuyuki Ushio

Journal of Organic Chemistry | 1979

Diisobutylaluminum 2,6-di-tert-butyl-4-methylphenoxide. Novel stereoselective reducing agent for prostaglandin synthesis

Sadahiko Iguchi; Hisao Nakai; Masaki Hayashi; Hisashi Yamamoto

Journal of Medicinal Chemistry | 1983

Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.

Yoshinobu Arai; Katsuichi Shimoji; Mitoshi Konno; Yoshitaka Konishi; Shigehiro Okuyama; Sadahiko Iguchi; Masaki Hayashi; Tsumoru Miyamoto; Masaaki Toda

Journal of Organic Chemistry | 1973

The synthesis of 16(R)- or 16(S) -methylprostaglandins.

Masaki Hayashi; Miyake H; Tadao Tanouchi; Sadahiko Iguchi; Y Iguchi

Journal of Organic Chemistry | 1992

An improved procedure of the Pechmann condensation in the synthesis of 8-ethyltrimethoxy-6H-benzo[d]naphtho[1,2-b]pyran-6-ones structurally related to the aglycon of gilvocarcins

Duy H. Hua; Shankar Saha; Didier Roche; Jin Coo Maeng; Sadahiko Iguchi; Christopher Baldwin

Synlett | 2002

Retention of Configuration in Displacement Reactions of 2-Chloro-1,3,2- oxazaphospholidin-2-one. Stereoselective 1,4-Addition Reaction of the Anion of Chiral 2-Propenylphosphonamide.

Duy H. Hua; Jin Chen; Shankar Saha; Hui Wang; Didier Roche; S. Bharathi; Roch Chan-Yu-King; Paul Robinson; Sadahiko Iguchi

Archive | 1977

15-Cycloalkyl-prostaglandin derivatives

Masaki Hayashi; Seiji Kori; Isao Ohyama; Sadahiko Iguchi; Takanori Okada

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Masaki Hayashi

Gunma University

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Duy H. Hua

Kansas State University

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Didier Roche

Kansas State University

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Katsuichi Shimoji

Harvard University

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Shankar Saha

Kansas State University

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Hisao Nakai

Nagoya University

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Hisashi Yamamoto

Chubu University

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Shigehiro Okuyama

Osaka University

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Hui Wang

Kansas State University

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Jin Chen

Kansas State University

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