Sadayoshi Yokoo

A case of a flare-up of systemic lupus erythematosus and Sjogren's syndrome manifesting with cholecystitis secondary to pregnancy

Abstracta 30-year- old had a 2 year history of systemic lupus erythematosus (SLE) was transferred to our hospital by her gynecologist because of a low-grade fever and dyspnea after delivery. Since a blood culture performed upon admission showed the presence ofBacteroides caccae, she was diagnosed with sepsis. Antibiotic therapy did not resolve her symptoms and she further developed an acute abdomen with marked cholecystitis. This was believed to be due to a flare-up of SLE after the pregnancy, overlapped with Sjögren’s syndrome which was evidenced by sialaden biopsy. She showed a good response to combination therapy with steroids and antibiotics.

Is Troglitazone a Real Indication for Obese Subjects With Impaired Glucose Tolerance

ations of parathyroid function should be investigated as a potential explanation for the associations between insulin and diabetes and bone mineral density An additional mechanism accounting for a reduction in bone formation is a direct effect of hyperglycemia on osteoblasts and their precursors. Advanced glycation end products (AGEs) have been found in the extracellular bone matrix in experimental studies. AGE-modified type I collagen has recently been demonstrated to inhibit osteoblastic function and may contribute to the reduced bone formation and, also by extension, to the reduction in bone turnover and activation frequency of bone remodeling (7). In fact, the trophic effect of insulin and various mechanisms reducing bone turnover may both contribute to the alterations of bone remodeling and the skeletal consequences of diabetes.