Sadayuki Horiki
Okayama University
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Publication
Featured researches published by Sadayuki Horiki.
Journal of Gastroenterology | 2000
Naoto Gotohda; Satoshi Itano; Yoshikatsu Okada; Sadayuki Horiki; Akira Endo; Norihiko Terada; Hiroshi Isozaki; Norihisa Takakura; Noriaki Tanaka
Abstract: We report a case of appendicitis caused by amebiasis in a 45-year-old Japanese man. He presented to our hospital with bloody stools in June 1998. Sigmoidoscopy disclosed erosion, and a biopsy of the erosion showed colitis caused by Entamoeba histolytica infection. Four months later, he was admitted to our hospital with a small elastic mass and severe pain in the lower quadrant of the abdomen, which was diagnosed as acute appendicitis. He underwent appendectomy. Histopathological examination revealed numerous E. histolytica trophozoites, and we diagnosed acute appendicitis caused by E. histolytica. The patient has been free of symptoms, colonoscopy has revealed no erosion, and biopsy has revealed no E. histolytica for 12 months after the operation.
Journal of Immunotherapy | 1992
Kazuhiko Kataoka; Yoshio Naomoto; Kazushi Kojima; Sadayuki Horiki; Akio Hizuta; Noriaki Tanaka; Norio Yahagi; Yoko Miyazaki; Ko Okumura; Kunzo Orita
Perforin is a protein present in the cytoplasmic granules of killer cells and is considered to be an important effector molecule. We assessed the perforin appearance via flow cytometry in human peripheral blood mononuclear cells stimulated in vitro for 3 days by recombinant interleukin-2 (rIL-2) or OK-432, a biological response modifier. The relationship between the lymphocyte subsets and perforin was investigated via two-color assay. CD4-positive cells had almost no perforin, and most of the CD16-positive cells did. Regarding the relationship with CD8, some of the bright positive cells (which were likely T cells) and most of the dull positive cells (likely NK cells) had perforin. Mean fluorescence was greatest in perforin-positive cells incubated with rIL-2, less in cells incubated with OK-432, and minimal in cells incubated in a medium without additives. Immunohistochemical staining with antiperforin antibody revealed that blast-transformed and enlarge cells were stained positively and that the intensity of staining of each cell alone was enhanced in cells incubated with OK-432 or rIL-2. If the fluorescence intensity of perforin-positive cells correlates with the amount of perforin in those cells, then the appearance of perforin was enhanced with OK-432, more enhanced with rIL-2, and consistent for cytotoxicity against K562 and Daudi cells. IL-2 was induced by OK-432, suggesting that the indirect effect of this IL-2 may play a role in OK-432-perforin induction. The results suggest that perforin may be an effector molecule in killer cells induced by rIL-2 or OK-432.
Journal of Hepato-biliary-pancreatic Surgery | 2000
Naoto Gotohda; Satoshi Itano; Sadayuki Horiki; Akira Endo; Atsunori Nakao; Norihiko Terada; Noriaki Tanaka
Acta Medica Okayama | 1998
Naoto Gotohda; Hiromi Iwagaki; Satoshi Itano; Sadayuki Horiki; Toshiya Fujiwara; Shinya Saito; Akio Hizuta; Hiroshi Isozaki; Norihisa Takakura; Norihiko Terada; Noriaki Tanaka
Human Pathology | 2006
Yasuyuki Ohtawa; Yoshio Naomoto; Yasuhiro Shirakawa; Munenori Takaoka; Toshihiro Murata; Ryotaro Sonoda; Kazufumi Sakurama; Tomoki Yamatsuji; Mehmet Gunduz; Hidetsugu Tsujigiwa; Hitoshi Nagatsuka; Norihiko Terada; Satoshi Itano; Sadayuki Horiki; Kazuyoshi Yanagihara; Motowo Nakajima; Noriaki Tanaka
Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 2005
Satoshi Itano; Norihiko Terada; Sadayuki Horiki; Akira Endo; Yasuyuki Ohtawa
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2008
Yasumoto Yamasaki; Satoshi Itano; Norihiko Terada; Sadayuki Horiki; Akira Endo
Acta Gastro-Enterologica Belgica | 2001
Satoshi Itano; Sadayuki Horiki; Norihiko Terada; Akira Endo; Masahiro Urakami; Naoto Gotohda; K. Matsumoto
Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi | 1999
Naoto Gotohda; Satoshi Itano; Sadayuki Horiki; Norihiko Terade; Masaharu Kodama
Acta Gastro-Enterologica Belgica | 2003
Satoshi Itano; Norihiko Terada; Sadayuki Horiki; Akira Endo; Yasuyuki Ohtawa; Masahiro Urakami; Yukiko Ikeda; K. Matsumoto