Sadia Khan
University of Karachi
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Sadia Khan.
Medicinal Chemistry Research | 2012
Tariq Harit; Fouad Malek; Brahim El Bali; Ajmal Khan; Kourosh Dalvandi; Bishnu P. Marasini; Shagufta Noreen; Rizwana Malik; Sadia Khan; M. Iqbal Choudhary
Three tridentate N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)-1-hydroxy-2-aminoethane (2), N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)-cyclohexylamine (3) and 2-[bis(1,5-dimethyl-1H-pyrazol-3-ylmethyl)amino]ethan-1-ol (4) are synthesized and spectroscopically characterized together with 1-hydroxymethyl-3,5-dimethylpyrazole (1). These have been tested in inhibitory activities against various hyperactive enzymes like urease, β-glucuronidase, phosphodiesterase, α-chymotrypsin, acetylcholinesterase and butyrylcholinesterase. Compounds 1, 2 and 3 were found to be selective inhibitors of urease. Compound 4 was found to be selective inhibitor of butyrylcholinesterase. The nature of the junction between pyrazoles cycles determined the activities of these tripods. While the tripods are inactive towards urease or glucuronidase, they turn to be selective towards butyrylcholinesterase.
Letters in Drug Design & Discovery | 2009
Khalid Mohammed Khan; Uzma Rasool Mughal; Sadia Khan; Saira Khan; Shahnaz Perveen; M. Iqbal Choudhary
A variety of imidazolones 1-34 derivatives were synthesized and tested for their antibacterial effects against Escherichia coli, Bacillus subtilis, Shigella flexnari, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi. Compound 18 found to be moderately active against S. flexnari, however, compounds 8, 11, 15, 21, 22, 25 showed to be moderate and compounds 31 and 34 exhibited good activities against P. aeruginosa. Compounds 7, 9, 12-14, 24-26, and 29 demonstrated good to excellent activity against S. typhi, while remaining compound did not show significant antibacte- rial activities. Compounds 7, 9, 12, 13, 14, 25, 26, 29 showed good activities against S. typhi. The antifungal activities of imidazolones were also determined against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glabrata and found that compounds showed varying degree of percentage inhibition.
Journal of Asian Natural Products Research | 2011
Sadia Khan; Rashad Mehmood; Mehdi Hussain Kazmi; Abdul Malik
Alliumonoate (1), a new cyclopentane derivative, has been isolated from the chloroform-soluble fraction of the ethanolic extract of Allium victorialis, along with β-amyrin acetate (2), β-sitosterol acetate (3), 22-cyclohexyl-1-docosanol (4), β-amyrin (5), β-sitosterol (6), and β-sitosterol 3-O-β-d-glucopyranoside (7), reported for the first time from this species. Their structures were elucidated on the basis of spectral data including mass spectra and 2D NMR experiments.
Archives of Pharmacal Research | 2017
Farah Inamullah; Itrat Fatima; Sadia Khan; Mehdi Hassan Kazmi; Abdul Malik; Rasool Bakhsh Tareen; Tanveer Abbas
Colucins A (1) and B (2), new flavonoids and colucone (3), the new chalcone derivative, have been isolated from the CHCl3-soluble fraction of the whole plant of Colutea armata along with luteolin (4), luteolin 7-O-β-D-glucoside (5), isoliquiritigenin (6), trans-caffeic acid (7) and stigmasterol (8) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobial activity against two Gram positive and three Gram negative bacterial strains while 3 was moderately active.
Chemistry of Natural Compounds | 2015
Sadia Khan; Itrat Fatima; Mehdi Hussain Kazmi; Abdul Malik; Nighat Afza; Lubna Iqbal; Mehreen Latif
Cashmins A (1) and B (2), two new coumarins, have been isolated from the chloroform-soluble subfraction of the methanolic extract of Sorbus cashmiriana Hedl. Both compounds showed potent antioxidant activity in different antioxidant assays.
Chemistry of Natural Compounds | 2016
Sundus Shabbir; Itrat Fatima; Farah Inamullah; Uzma Rasheed Mughal; Sadia Khan; Mehdi Hassan Kazmi; Abdul Malik; Rasool Bakhsh Tareen; Tanvir Abbas
Brahin (1), a new ursene-type triterpene, has been isolated from the CHCl3-soluble fraction of Spiraea brahuica together with β-sitosterol (2), 3-(3,4-dimethoxyphenyl)-2-propenal (3), and cinnamic acid (4), which are reported for the first time from this species. The structures of these compounds were elucidated by 1D and 2D NMR spectroscopic techniques. Brahin showed moderate inhibitory activity against the enzyme lipoxygenase.
Chemistry of Natural Compounds | 2016
Unber Shakeel; Farah Inamullah; Itrat Fatima; Sadia Khan; Mehdi Hassan Kazmi; Abdul Malik; Rasool Bakhsh Tareen; Tanvir Abbas
A new isoflavan, colutin (1), has been isolated from the EtOAc soluble fraction of the MeOH extract of Colutea armata, along with three known compounds, sativan (2), isovestitol (3), and cinnamic acid (4), isolated for the first time from this species. Their structures were elucidated by spectroscopic techniques including two-dimensional NMR. Colutin (1) showed significant antifungal activity.
Chemistry of Natural Compounds | 2015
Sadia Khan; Itrat Fatima; Mehdi Hassan Kazmi; Abdul Malik
Allumine C (1), a new steroidal alkaloid, has been isolated from the CHCl3-soluble fraction of the whole plant of Allium victorialis L. Its structure was elucidated by chemical and spectral studies.
Archive | 2009
Alembert T. Tchinda; Victorine Fuendjiep; Ali Sajjad; Sadia Khan; Muhammad Iqbal Choudhary
Journal of Molecular Catalysis B-enzymatic | 2010
Syed Ghulam Musharraf; Asma Najeeb; Sadia Khan; Masood Pervez; Rahat Azher Ali; M. Iqbal Choudhary