Sadık Görür

Incidence of the Retroaortic Left Renal Vein in Patients With Varicocele

The purpose of this study was to investigate the incidence of the retroaortic left renal vein (RLRV) in patients with varicocele.

EEG abnormalities during treatment with tadalafil, a phosphodiesterase type 5 inhibitor

Abstract Objective: Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. Method: EEG recordings from 35 erectile dysfunction patients taking tadalafil (20 mg) were graded for severity of EEG abnormalities (at admission, 2 and 48 hours after tadalafil administration). Results: At admission, there were no EEG abnormalities. At second EEG, abnormalities occurred in 12 (34.3%) of the 35 patients. Eight (22.9%) patients had mild and four (11.4%) patients had moderate EEG abnormalities. At third EEG, one (2.9%) patient had mild and one (2.9%) patient had moderate EEG abnormalities. Conclusion: PDE-5 inhibitors may produce EEG abnormalities. Although the exact role of PDE in altering susceptibility to seizure remains unclear, epileptic seizures may occur during treatment with PDE inhibitors.

Preventive effect of rolipram, a phosphodiesterase 4 enzyme inhibitor, on oxidative renal injury in acute ascending pyelonephritis model in rats.

OBJECTIVES To evaluate the effects of rolipram, a phosphodiesterase 4 enzyme inhibitor, on Escherichia coli-induced renal oxidative damage in an acute pyelonephritis (PYN) rat model. METHODS A total of 35 male Wistar albino rats were randomly divided into 7 groups (n = 5) as follows: control (uninfected), PYN 24 hours, PYN 48 hours, PYN 72 hours, PYN + rolipram 24 hours, PYN + rolipram 48 hours, and PYN + rolipram 72 hours. Ascending PYN was induced in the study groups by E. coli inoculation into the bladder, and the urethras were then occluded by collodium for 4 hours. Rolipram injections (1 mg/kg) were started before bacterial inoculation and repeated at 24-hour intervals in the PYN + rolipram groups until death. The rats were killed at the indicated times. Malondialdehyde and nitric oxide levels and superoxide dismutase and catalase activities were determined in kidney homogenates. Histopathologic examinations were also performed. RESULTS Tissue malondialdehyde and nitric oxide levels and superoxide dismutase and catalase activities were significantly increased in the kidneys from the PYN groups. However, rolipram administration reduced renal malondialdehyde and nitric oxide levels and enhanced superoxide dismutase and catalase activities. The histopathologic examinations demonstrated that rolipram treatment reduced the inflammation grade in the kidney specimens. CONCLUSIONS The results of our study have shown that rolipram has a protective effect on renal tissue from E. coli-induced oxidative injury. Therefore, phosphodiesterase 4 inhibitors might be a novel therapeutic option for the prevention and/or management of acute PYN.

Toxic effects of formaldehyde on the urinary system.

Formaldehyde is a chemical substance with a pungent odor that is highly soluble in water and occurs naturally in organisms. Formaldehyde, when taken into organisms, is metabolized into formic acid in the liver and erythrocytes and is then excreted, either with the urine and feces or via the respiratory system. Form-aldehyde is widely used in the industrial and medical fields, and employees in these sectors are frequently exposed to it. Anatomists and medical students are affected by formaldehyde gas during dissection lessons. Because full protection from formaldehyde is impossible for employees in industrial plants using this chemical and for workers in laboratory conditions, several measures can be implemented to prevent and/or reduce the toxic effects of formaldehyde. In this review, we aimed to identify the toxic effects of formaldehyde on the urinary system.

PATOLOJİK T3 EVRE PROSTAT KANSERİNDE CERRAHİ SINIR POZİTİFLİĞİ VE RADYOTERAPİ

Prostate cancer is the most common solid cancer in men and of %91 is diagnosed as organ confined early stage. Extraprostatic invasion of the disease comes with the increased risk of surgical margin positivity in the postoperative period. Postoperative treatment with radiotherapy (RT) for the patients that have surgical margin positivity in the pathologic specimens reserve a crucial place. This review contains the knowledge of the importance and role of radiotherapy in surgical margin-positive prostate cancer patients compiling from the literature. Key Words: Prostate cancer, Radiotherapy, Surgical margin positivity

Erectil Dysfunction Therapy and Penile Rehabilitation After Radical Prostatectomy

Yaz›flma Adresi / Address for Correspondance: Dr. Sadık Görür, Ürgen Paşa Mah. 75. Yıl Bulvarı. Cem Apt. No: 10/17, 31100 Antakya, Hatay, Türkiye Tel: 0533 731 63 71 Faks: 0326 245 53 05 E-posta: sadikgorur@yahoo.com doi:10.5152/tus.2010.08 Radikal Prostatektomi Sonrası Erektil Disfonksiyon Tedavisi ve Penil Rehabilitasyon Erectil Dysfunction Therapy and Penile Rehabilitation After Radical Prostatectomy