nan Sadiq‐ur‐Rehman

Synthesis, Spectroscopic Characterization: (IR, Multinuclear NMR, 119mSn Mössbauer and Mass Spectrometry), and Biological Activity (Antibacterial, Antifungal, and Cytotoxicity) of Di‐ and Triorganotin(IV) Complexes of (E)‐3‐(4‐Chlorophenyl)‐2‐phenylpropenoic Acid

Abstract In an effort to develop new organotin(IV) compounds of industrial and biological importance, a series of di‐ and triorganotin(IV) complexes of (E)‐3‐(4‐chlorophenyl)‐2‐phenylpropenoic acid with the general formula R4‐n SnL n have been synthesized by the reaction of the corresponding organotin chlorides with the sodium salt of (E)‐3‐(4‐chlorophenyl)‐2‐phenylpropenoic acid (C15H10ClO2Na) where, R = CH3, C2H5, n‐C4H9, C6H5, C6H5 · CH2, n = 1 or 2 and L = acid anion (C15H10ClO2 −). The dimeric tetraorganodicarboxylatodistannoxanes [(Me2SnL)2O]2 compound (2) and [(Bu2SnL)2O]2 compound (4), L = C15H10ClO2 −, were synthesized by the reaction of R2SnO with the ligand acid (HL) in 1:1 molar ratio with azeotropic removal of water. The structures of the complexes are discussed on the basis of IR, multinuclear (1H, 13C, 119Sn) NMR, 119mSn Mössbauer spectroscopies and mass spectrometry. The spectroscopic results substantiate that all the diorganotin(IV) derivatives possess trigonal‐bipyramidal structures in solution and octahedral geometry in the solid state. A linear polymeric trigonal‐bipyramidal structure in the solid state and a tetrahedral environment around the tin atom in non‐coordinating solvents has been proposed for the triorganotin(IV) derivatives. The Δν [Δν = νasym(COO) − νsym(COO)] values obtained from the IR data, in comparison to the ligand acid and its sodium salt, fall in the range which shows that the ligand may act as a bidentate coordinating group through the carboxyl (COO) oxygen atoms. The biological activity and LD50 data of the synthesized compounds are also reported. The triorganotin(IV) complexes exhibit significantly better activities than the diorganotin(IV) derivatives. The LD50 data show that most of the investigated compounds are cytotoxic.

Synthesis and Spectral Studies (FT‐IR, 1H, 13C, 119Sn, and Mass Spectrometry) of Mixed Organotin(IV) Compounds Containing a Long Chain Alkyl Group (n‐C7H15)

Abstract Di‐ and triorganotin(IV) compounds of the type R2SnR2′ and R3SnR′ (R = CH3, n‐C4H9, C6H5, C6H5CH2 and R′=n‐C7H15) have been prepared by the reaction of R2SnCl2 and R3SnCl with a stoichiometric amount of n‐heptylmagnesium bromide, prepared in situ in dry diethyl ether. The products obtained were vacuum distilled. The structural assignments were made on the basis of spectral studies such as FT‐IR, 1H, 13C, 119Sn NMR, and mass spectrometry which ascertain the tetrahedral environment around the tin atom.

Poly[μ2‐chlorido‐nonamethyl‐μ3‐nitrato‐tritin(IV)]

The crystal structure of the title compound, [Sn3(CH3)9Cl(NO3)], contains trigonal–bipyramidal Sn atoms with three methyl groups bonded in the equatorial plane and an O atom of the NO3 group and a Cl atom in the axial sites. The Cl atom, which lies on a threefold axis, is bridged between three Sn atoms, with Sn—Cl distances of 2.9298u2005(13)u2005A. The N atom of the NO3 group also lies on a threefold axis, with its O atoms bonded to three Sn atoms. Thus, polymeric sheets are formed parallel to the ab plane.

catena‐Poly­[[tri­methyl­tin(IV)]‐μ‐2‐(4‐chloro­phenyl)‐3‐(4‐methoxy­phenyl)­propenoato‐κ2O:O′]

The title compound, [Sn(CH3)3(C16H12ClO3)]n, forms polymeric chains incorporating both O atoms of the propenoate ligand. The coordination geometry around the Sn atom is distorted trigonal bipyramidal. The three methyl C atoms occupy the equatorial positions with almost identical Sn—C distances [2.115u2005(3)–2.120u2005(3)u2005A] and O atoms from two symmetry-related ligands are in the axial positions with significantly different Sn—O distances [2.150u2005(2) and 2.430u2005(2)u2005A].

Tetra­butyl­bis­[3‐(4‐methoxy­phenyl)‐2‐phenyl‐2‐propenoato]­distannoxane dimer

The crystal structure of the title compound, bisxad[μ2-3-(4-methoxyxadphenyl)-2-phenyl-2-propenoato]xadbisxad[3-(4-methoxyxadphenyl)-2-phenyl-2-propenoato]xaddi-μ3-oxo-tetrakisxad[dixadbutylxadtin(IV)], [Sn4(C4H9)8(C17H15O2)4O2], is composed of centrosymmetric dimers in which dixadbutylxadbis{[3-(4-methoxyxadphenyl)-2-phenyl-2-propenoato]xadtin} units containing monodentate and bridging bidentate ligands are coordinated to the central Sn2O2 core through its O atoms. Both Sn atoms adopt distorted trigonal bipyramidal geometry, with Sn—C distances lying in a narrow range 2.096u2005(13)–2.161u2005(6)u2005A, while Sn—O distances range between 2.041u2005(2) and 2.262u2005(3)u2005A.

catena-Poly­[[tri­methyl­tin(IV)]-μ-3-(4-chloro­phenyl)-2-phenylpropenoato-κ2O:O′]

The crystal structure of the title compound, [Sn(CH3)3(C15H10ClO2)]n, contains polymeric chains along the b axis. The geometry around the Sn atom is distorted trigonal bipyramidal, wherein three methyl groups are bonded to the Sn atom at equatorial positions with essentially identical bond distances [mean Sn—C = 2.119u2005(6)u2005A] and two O atoms of the carboxylate ligand are bonded asymmetrically with significantly different Sn—O distances of 2.159u2005(2) and 2.351u2005(2)u2005A.

Erratum: Poly[μ(2)-chlorido-nona-methyl-μ(3)-nitrato-tritin(IV)]. Corrigendum.

Corrigendum to Acta Cryst. (2007), E63, m2329.

Poly(l2-chlorido-nonamethyl-l3-nitrato- tritin(IV)). Corrigendum

Corrigendum to Acta Cryst. (2007), E63, m2329.

Di-n-butylbis[(E)-2-(4-chlorophenyl)-3-(3-fluorophenyl)prop-2-enoato-κ2 O,O]tin(IV)

The molxadecule of the title compound, [Sn(C4H9)2(C15H9ClFO2)2], has a skewed-trapezoidal planar geometry, defined by four O donors from the carboxylxadate ligands and two C atoms from the n-butyl groups. The C—Sn—C bond angle is 133.95u2005(12)°. The O atoms of the carboxylxadate ligands are bonded asymmetrically to Sn, with significantly different Sn—O distances; the values for the shorter are 2.0914u2005(18) and 2.1134u2005(19)u2005A, while the longer Sn—O distances are 2.513u2005(2) and 2.650u2005(2)u2005A.

catena-Poly­[[tri­methyl­tin(IV)]-μ-2,3-bis(4-chloro­phenyl)­propenoato-κ2O:O′]

The title compound, [Sn(CH3)(3)(C15H9Cl2O2)]n, forms polymeric chains involving both O atoms of the carboxylate group. The coordination geometry around the Sn atom is distorted trigonal-bipyramidal. The three methyl C atoms occupy the equatorial positions, with Sn-C distances of 2.113 (3)- 2.124 (2) Angstrom, and two O atoms, including one from a symmetry-related molecule, are at the axial positions, with Sn-O distances of 2.152 (2) and 2.454 (2) Angstrom.