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Dive into the research topics where Sagrario Mochales is active.

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Featured researches published by Sagrario Mochales.


Applied Microbiology and Biotechnology | 1993

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protien transferase

Russell B. Lingham; Keith C. Silverman; Gerald F. Bills; Carmen Cascales; Manual Sanchez; Rosalind G. Jenkins; Suzanne E. Gartner; Isabel Martin; Maria Teresa Diez; Fernando Pelaez; Sagrario Mochales; Yu Lin Kong; Richard W. Burg; Maria S. Meinz; Leeyuan Huang; Mary Nallin-Omstead; Scott D. Mosser; Michael D. Schaber; Charles A. Omer; David L. Pompliano; Jackson B. Gibbs; Sheo B. Singh

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.


The Journal of Antibiotics | 1987

Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. I. Production, taxonomy and antibacterial activity.

Sheldon B. Zimmerman; Cheryl D. Schwartz; Richard L. Monaghan; Barbara A. Pelak; Barbara Weissberger; Evemarie C. Gilfillan; Sagrario Mochales; Sebastian Hernandez; Sara A. Currie; Enrique Tejera; Edward O. Stapley


Mycologia | 2000

Phylogenetic study of Hypoxylon and related genera based on ribosomal ITS sequences

Javier Sanchez-Ballesteros; Vicente Gonzalez; Oscar Salazar; Javier Acero; Maria A. Portal; Maria Julian; Víctor J. Rubio; Gerald F. Bills; Jon D. Polishook; Gonzalo Platas; Sagrario Mochales; Fernando Pelaez


The Journal of Antibiotics | 1987

Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase

Satoshi Omura; Hiroshi Tomoda; Hidetoshi Kumagai; Michael D. Greenspan; Joel B. Yodkovitz; Julie S. Chen; Alfred W. Alberts; Isobel Martin; Sagrario Mochales; Richard L. Monaghan; John C. Chabala; Robert E. Schwartz; Arthur A. Patchett


The Journal of Antibiotics | 1992

A NOVEL INOSITOL MONO-PHOSPHATASE INHIBITOR FROM Memnoniella echinata

Y. K. T. Lam; Carol F. Wichmann; M. S. Meinz; L. Guariglia; Robert A. Giacobbe; Sagrario Mochales; Li Kong; Susan S. Honeycutt; Deborah L. Zink; Gerald F. Bills; Leeyuan Huang; Richard W. Burg; Richard L. Monaghan; R. Jackson; G. Reid; J. J. Maguire; A. T. Mcknight; C. I. Ragan


Archive | 1988

Sterol inhibitors of testosterone 5 alpha -reductase

Robert P. Borris; Richard W. Burg; Otto D. Hensens; Leeyuan Huang; Livia Kelemen; Sagrario Mochales


Archive | 1987

Sterol inhibitors of testosterone 5α-reductase

Robert P. Borris; Richard W. Burg; Otto D. Hensens; Leeyuan Huang; Livia Kelemen; Sagrario Mochales


Archive | 1992

Immunosuppressant-producing culture

Shieh-Shung T. Chen; Byron H. Arison; George M. Garrity; Edward S. Inamine; Sagrario Mochales; Linda S. Wicker


Archive | 1991

Xanthomegnin, a known compound, is an antiparasitic agent

Dan A. Ostlind; Sagrario Mochales


Archive | 1989

NEW IMMUNOSUPPRESSANT-PRODUCING CULTURE

Shieh-Shung T. Chen; Edward S. Inamine; Byron H. Arison; George M. Garrity; Sagrario Mochales; Linda S. Wicker

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