Saidul Zafar Qureshi

Simultaneous spectrophotometric and volumetric determinations of amoxycillin, ampicillin and cloxacillin in drug formulations: reaction mechanism in the base catalysed hydrolysis followed by oxidation with iodate in dilute acid solution.

A method for the analysis of degraded products of amoxycillin, ampicillin and cloxacillin in drug formulations, obtained as a result of their base hydrolysis is described. Simultaneous spectrophotometric and volumetric determinations of the antibiotic is based on the neutralization of the degraded product by dilute hydrochloric acid to get a pH approximately 2 to be conducive for redox titration using potassium iodate as titrant. A red purple colour is developed in carbon tetrachloride at the end point. Spectrophotometry is done after separating the organic layer and measuring the absorbance of red-purple colour at lambda(max) 520 nm. The pathways of different degraded products and their oxidation mechanism is described on IR, TLC and UV spectroscopic studies.

Extraction spectrophotometric method for the determination of ascorbic acid in pharmaceutical preparations, urine and fruit juices with potassium iodate

An indirect determination of ascorbic acid is based on extraction of the iodine produced by reduction of potassium iodate. Beers law is obeyed over the range 0.02-0.36 mg/ml ascorbic acid.

Spectrophotometric determination of novalgin in tablets by use of potassium iodate

An indirect colour reaction has been studied for determination of novalgin in tablets. The method is simple, rapid and reproducible with a relative standard deviation of 0.2%. Novalgin is determined spectrophotometrically by means of its colour reaction with potassium iodate. Beers law is obeyed over the range 1-10 mg of drug. A tentative reaction mechanism has been proposed.

An ion-exchange method for the detection of amides, imides and anilides

Abstract Ion-exchange resins are efficient catalysts for the acid hydrolysis of amides, imides and anilides; the ammonium ion or aniline so formed can be detected by the well-known specific tests for these species. In general, the proposed tests are simpler, faster and more selective than those already available. The amounts that can be detected are of the order of 0.05–5 μg depending on the compound.

Some observations on a simple method for the determination of novalgin in drug formulations with iron(III)-1,10-phenanthroline

Abstract An accurate and simple spectrophotometric method for the determination of novalgin has been developed. The method is based on reduction of iron(III) with novalgin and subsequent complexation of iron(II) with 1,10-phenanthroline. The method has been applied to the determination of novalgin in drug formulations and interferences by excipients have been checked.

Resin bead detection and spectrophotometric determination of oxyphenbutazone with p-dimethylaminocinnamaldehyde: Application to bulk drug and dosage forms.

An analytical method for resin bead detection and spectrophotometric determination of oxyphenbutazone with p-dimethylaminocinnamaldehyde as a reagent is described. Acid hydrolysed product of oxyphenbutazone produced a red color product with p-dimethylaminocinnamaldehyde that absorbs maximally at 520 nm. The detection limit is 0.8 mug in resin phase and 4.0 mug in aqueous phase. Beers law is obeyed in the concentration range of 0.4-4.0 mug/ml of oxyphenbutazone. The method is unaffected by the presence of acetylsalicylic acid, salicylamide, phenylbutazone and number of other excipients but paracetamol gives a positive reaction and novalgin being reductone interferes with the test, both should be removed by extraction with dilute sulfuric acid.

Sensitive and selective ion exchange test for microgram detection and spectrophotometric determination of picric acid

Abstract The microgram detection and determination of picric acid with sodium hypochlorite solution is based on its oxidation in alkaline solution and chlorination with excess of chlorine present in hypochlorite solution. A characteristic orange color is obtained, which can be used as a specific test. The sensitivity of the picric acid was enhanced by performing the resin spot test. This color reaction was applied for the determination of picric acid spectrophotometrically.

Selective role of oxidants in the presence of cation-exchange resins in Na+-form for the detection and differentiation of acidic, basic and neutral amino-acids

A test for detection and differentiation of acidic, basic and neutral amino-acids is based on use of a sulphonic acid cation-exchange resin in Na(+)-form, in the presence of various oxidants (permanganate, dichromate, chromate, iodate, peroxide) and final detection with Nesslers reagent.

A new ion-exchange test for detection of ketones on the microgram scale

A test for the detection of certain ketones is based on the reaction with 1-chloro-2,4-dinitrobenzene in the presence of an anion-exchange resin in the OH(-) form, to give a violet colour on the resin bead surface.

Recent Progress in Ion-Exchange Studies on Insoluble Salts of Polybasic Metals

Abstract Zirconium phosphate is perhaps the first insoluble salt of a polybasic metal to be used as an ion exchanger. It is the most studied and probably the most useful of all the materials of this type. These materials are prepared by combining oxides of group IV with the more acidic oxides of groups V and VI of the periodic table, as shown in Table 1.