Sajid Jahangir

1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl acetate

In the title compound, C9H13N3O4, an ester of the anti-infection drug secnidazole, the dihedral angle between the nitroimidazole mean plane (r.m.s. deviation = 0.028 Å) and the pendant acetate group is 43.17 (11)°. In the crystal, inversion dimers linked by pairs of C—H⋯O interactions generate R 2 2(10) loops and further C—H⋯O hydrogen bonds link the dimers into [100] chains. Weak aromatic π–π stacking interactions with a centroid–centroid distance of 3.7623 (11) Å are also observed.

In vitro Studies of Interaction Between Dexamethasone and NSAIDS by Using RP-High Performance Liquid Chromatography

Abstract Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used because of their remarkable cure over mild and moderate pain including osteoarthritis and rheumatoid arthritis. Medical doctors commonly prescribe steroidal drugs in combination with the NSAID’s therefore we have developed a method to evaluate the percent availability of these two classes of drugs and analyzed their possible interactions. The proposed method is validated according to the International Conference on Harmonization (ICH) guide lines on RP-HPLC (Reverse Phase High Performance Liquid Chromatography). A good chromatographic separation was achieved using a mobile phase containing methanol-water (80:20 v/v) at pH = 3.2 with a flow rate of 1.0 mL/min (detection at 265 nm with a UV-vis detector). The in-vitro interaction study was conducted at physiological conditions (i.e. temperature 37°C and stomach pH = 3.2). The method provided a very good percent recovery of different molecules. The percent recovery of Piroxicam, Naproxen sodium, Flurbiprofen and Ibuprofen are 100.539, 100.373, 99.683 and 100.840 respectively. The results indicated that percent availability of all NSAIDs and dexamethasone reduced during the time interval 2.5 h which is likely due to the formation of charge transfer complexes. We can conclude that simultaneous administration of these drugs may alter their bio-availability.

Phytochemical and Biological Activities of Pseudocalymma elegans: A False Garlic

Evaluation of phytochemical constituents and antioxidant and antimicrobial activities of hexane (PELH), dichloromethane (PELDCM), ethyl acetate (PELEA), and MeOH (PELM) extracts of young leaves of Pseudocalymma elegans have been carried out. Moreover, extracts have also been explored for the presence of sulphur containing compounds, 1,2‐dithiolane (33), diallyl disulfide (35), 3‐vinyl‐1,2‐dithiacyclohex‐5‐ene (37), and diallyl trisulfide (38) responsible for the garlic like smell of P. elegans. All the extracts were found to be antioxidant and showed potent inhibition with IC50 values of 0.168 ± 0.001, 0.128 ± 0.002, 0.221 ± 0.011, and 0.054 ± 0.001, respectively, as compared to standard drugs ascorbic acid (AA) and butylated hydroxytoluene (BHT). The ethyl acetate extract (PELE) showed excellent activities against few Gram‐positive and Gram‐negative bacteria and some fungi as compared with standard drug ceftriaxone (3rd generation cephalosporin) and nystatin, respectively. Chemical constituents of hexane, dichloromethane, and ethyl acetate extracts were identified by gas chromatography‐mass spectrometry and mass spectral library search. Over all 55 chemical constituents were first time identified from the leaves which included branched and n‐hydrocarbons, fatty acids, fatty acid methyl esters, fatty alcohols, terpenes, alkaloid, vitamins, glycosides, aromatic compounds, and sulfur containing compounds. Two known chemical constituents, ursolic acid (1) and β‐amyrin (2), were also purified for the first time from the MeOH extract. To elucidate the structures of these compounds, UV, IR, EI‐MS, 1H‐ and 13C‐NMR spectroscopy were used.

Crystal structure of 2-{[1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl-oxy]carbon-yl}benzoic acid.

In the title compound, C15H15N3O6, the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10)°. An intramolecular C—H⋯O hydrogen bond is observed. In the crystal, O—H⋯N hydrogen bonds link the molecules into chains parallel to the c axis.