Sakurai M
Mie University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Sakurai M.
Urologia Internationalis | 1993
Kawamura J; Sakurai M; Katsumi Tsukamoto; Tochigi H
We report a case of leiomyosarcoma in the bladder which occurred in an 18-year-old boy who had been treated with cyclophosphamide over a period of 6 years for retinoblastoma diagnosed 50 days postpartum. Total cystectomy and formation of an ileal conduit were performed. Three years after the operation, he was tumor-free.
Urologia Internationalis | 2003
Hiroshi Matsuura; Sakurai M; Kiminobu Arima
A case of recurrent eosinophilic cystitis with peripheral eosinophilia and hyperimmunoglobulinemia E, which responded successfully to initial and secondary steroid therapies is reported.
FEBS Letters | 1988
Hiroshige Hibasami; Masahiro Kawase; Tetsuya Tsukada; Satoru Maekawa; Sakurai M; Kunio Nakashima
Spermidine synthase from rat ventral prostate was inhibited by 2‐mercaptoethylamine (MEA). Inhibition of spermidine synthase by MEA was competitive with respect to one of the substrates putrescine, but not competitive with respect to the other substrate decarboxylated S‐adenosylmethionine. MEA markedly depressed spermidine and spermine contents in human erythroid leukemia K562 cells, suggesting that these changes resulted from the inhibitory effect of MEA on spermidine synthase in situ.
Cancer Letters | 1988
Hiroshige Hibasami; Sakurai M; Satoru Maekawa; Taku Murata; Kunio Nakashima
Difluoro-phenyl-ethyl(4-aminopropylamidinohydrazone) (DFPA) was synthesized as an irreversible inhibitor of ornithine and S-adenosylmethionine decarboxylases and analyzed for antiproliferative effects on leukemia cells. The compound irreversibly inhibited ornithine and S-adenosylmethione decarboxylases. This inhibition could not be reversed by dialysis or chromatography on Sephadex G-50. When human lymphoid leukemia Molt 4B cells were cultured in the presence of the inhibitor, the intracellular levels of polyamines (putrescine, spermidine and spermine) and the rate of cell proliferation were markedly depressed. In these polyamine-depleted and growth-retarded cells, the synthesis of protein, but not of DNA or RNA, was observed to be significantly inhibited.
Biochemical and Biophysical Research Communications | 1987
Hiroshige Hibasami; Tetsuya Tsukada; Satoru Maekawa; Sakurai M; Kunio Nakashima
Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. The increase of ODC activity was due to the enhanced syntheses of mRNA and protein. The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG).
The Japanese Journal of Urology | 1999
Hiroshi Matsuura; Sakurai M; Kiminobu Arima
We reported the experience of high-dose chemotherapy (HDC) combined with peripheral stem cell transplantation (PBSCT) in 29 years-old man with advanced retroperitoneal germ cell tumor accompanied with left supraclavicular lymph node metastases, who obtained complete remission after comprehensive treatment. The initial levels of serum AFP, hCG and beta-hCG were high at 30.2 ng/ml, 14,000 mIU/ml and 66 ng/ml, respectively. After 3 courses of chemotherapy (BEP regimen), while left supraclavicular lymph node swelling was disappeared, the retroperitoneal mass lesion persisted on CT scan. Not all of 3 markers fell to the normal range. After myelosuppressive chemotherapy (etoposide 500 mg/m2 Day 1-3), PBSCs were collected by two consecutive apheresises on Day 17 and 18. In total, 19.5 x 10(6)/kg CD 34 positive cells were obtained. The patient underwent PBSCT (all CD 34 positive cells were infused) on Day 0 following HDC (CBDCA 250 mg/m2/day, etoposide 300 mg/m2/day, IFM 1.5 g/m2/day, Day-7(-)-3, respectively). He became severely leukopenic and thrombopenic with nadir of 200/microliter on Day 6 and 2 x 10(4)/microliter on Day 2, respectively. By administration of platelet transfusion and G-CSF, the white blood cell counts and thrombocyte counts recovered to 6,400/microliter and 4.1 x 10(4)/microliter on Day 10, respectively. Microbiologically enterocolic and respiratory tract infections occurred with elevated body temperature (> 40 degrees C). Antibiotic and antimycotic treatments were continued until disappearance of all clinical and microbiological evidence. He was kept for 10 days in clean room. After HDC, all markers fell to the normal range, but the retroperitoneal residual mass still persisted. Resection of the residual mass and retroperitoneal lymph node dissection were performed with pathological examination revealing tissue necrosis without viable cell. The patient has survived with no sign of the disease for 9 months.
The Prostate | 1994
Yoshiki Sugimura; Sakurai M; Norio Hayashi; Atsushi Yamashita; Kawamura J
Carcinogenesis | 1988
Hiroshige Hibasami; Tetsuya Tsukada; Satoru Maekawa; Sakurai M; Kunio Nakashima
Hinyokika kiyo. Acta urologica Japonica | 1993
Sakurai M; Yoshiki Sugimura; Satani H; Kameda K; Kurimoto K; Oonishi Y; Norio Hayashi; Kiminobu Arima; Tochigi H; Kawamura J
Hinyokika kiyo. Acta urologica Japonica | 1994
Matsuura H; Hioki T; Sakurai M; Kiminobu Arima; Yanagawa M; Yoshiki Sugimura; Tochigi H; Kawamura J; Kinoshita N; Katoh H