Salah El-Akkad

Gastrointestinal lymphoma in adults: Clinical features and management of 300 cases

BACKGROUND/AIMS Gastrointestinal lymphoma is a rare disease. A study was conducted to assess its prevalence and clinical features in adult patients with lymphoma. METHODS Retrospective analysis of 1352 patients with adult non-Hodgkins lymphoma showed 300 (22%) cases with gastrointestinal involvement at initial presentation. RESULTS Of the 185 patients with primary gastrointestinal lymphoma, 94 (51%) had gastric primary lymphoma and the rest (49%) had a lymphoma of intestinal origin. Patients with intestinal lymphoma were considerably younger (median age, 35.0 years), frequently had multifocal disease (14%), and had a 10-year survival rate of 48%. Cases with gastric primary lymphoma had a median age of 54.5 years (P < 0.001) and rarely had multifocal disease (1%; P < 0.001) but had an equal 10-year survival rate of 53% (P = 0.431). For both groups, the combined surgical resection followed by chemotherapy led to better 10-year survival (45%) compared with either modality used alone (0% and 35%, respectively; P < 0.05). Better survival was also noted in ambulatory patients, younger patients, those with localized disease, and those without intestinal perforation. Another 115 patients had gastrointestinal involvement secondary to disseminated disease with frequent high-grade histology (29%) and a poor 10-year survival rate of 22%. CONCLUSIONS Gastrointestinal involvement is relatively common in patients with adult lymphoma. Multimodality treatment appeared superior to therapy with either surgery or chemotherapy used alone.

Colorectal Carcinoma During the First Four Decades of Life

ABSTRACT The clinical and pathologic characteristics of colorectal cancer were studied in patients 40 years of age and younger. The patients were divided into two groups: (1) those in whom the mali...

Nasopharyngeal Carcinoma in Saudi Arabia: Selected Clinical and Epidemiological Aspects

A retrospective review of 381 patients with histologically confirmed nasopharyngeal carcinoma referred from all regions of Saudi Arabia to the King Faisal Specialist Hospital and Research Centre du...

Neutron therapy in saudi arabia: An overview and results of dose searching study in head and neck cancer

The King Faisal Specialist Hospital and Research Centre is the only center in the Middle East that incorporates a neutron therapy facility. The neutron beam is produced by a cyclotron, which produces a beam by either a (d(15)+Be) or (p(26)+Be) reaction. The beam from the proton reaction is selected for therapy because of its superior physical characteristics. These were verified by an intercomparison conducted by the European Organization for Research on Treatment of Cancer (EORTC) Heavy Particle Therapy Group. Full beam data are presented. The first study in the neutron therapy Program is on the treatment of squamous cancers of the head and neck. This consists of two parts. Part I is a dose searching phase and Part II is a comparison of our current photon treatment versus neutrons using the neutron dose selected by Part I of the study. Results of the dose searching phase (Part I) are presented.

Spindle and Giant Cell Carcinoma of the Thyroid

ABSTRACT A retrospective chart review of all 15 patients presenting with anaplastic spindle and giant cell carcinoma of the thyroid at King Faisal Specialist Hospital between July 1975 and June 198...

Preoperative Chemotherapy in the Management of Esophageal Carcinoma: Preliminary Report

ABSTRACT Carcinoma of the esophagus is the most common malignancy of the digestive system seen in our institution. Since mid-1982, a multidrug regimen including fluorouracil, doxorubicin, cisplatin...

Therapy for Ewing's Sarcoma: King Faisal Specialist Hospital and Research Centre Experience

ABSTRACT Forty-one patients with histologically confirmed diagnosis of Ewing’s sarcoma were treated between the years 1976 and 1983. Thirty patients without metastasis at diagnosis were treated wit...

A New Simple Afterloading Applicator for Gynecological Intracavitary Therapy

ABSTRACT The description, technique, and advantages of an improvised, simple afterloading applicator for treatment of uterine-cervical carcinoma at the King Faisal Specialist Hospital and Research ...