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Dive into the research topics where Samantha Martin is active.

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Featured researches published by Samantha Martin.


Oncotarget | 2016

Primary tumor microRNA signature predicts recurrence and survival in patients with locally advanced esophageal adenocarcinoma

Daisuke Matsui; Ali H. Zaidi; Samantha Martin; Ashten N. Omstead; Juliann E. Kosovec; Luai Huleihel; Lindsey T. Saldin; Christina DiCarlo; Jan Silverman; Toshitaka Hoppo; Gene Grant Finley; Stephen F. Badylak; Ronan J. Kelly; Blair A. Jobe

Esophageal adenocarcinoma (EAC) is an aggressive cancer necessitating the development of improved risk stratification tools for personalized care. Previously, microRNAs have been shown to correlate with the progression and prognosis of various cancer types; however, the value in EAC remains largely unexplored. We performed global microRNA profiling on 32 formalin-fixed, paraffin-embedded EAC specimens to identify microRNAs associated with progression. Literature search and pathway analysis further refined output to five significantly deregulated candidate biomarkers. Four of the five microRNAs (miR-652-5p, miR-7-2-3p, miR-3925-3p, and miR-219-3p) were validated by qRT-PCR. Survival outcomes were evaluated in testing set of 26 stage II/III EAC patients to determine the prognostic relevance of the selected microRNAs. In the testing set, miR-652-5p and miR-7-2-3p expressions were significantly associated with progression-free survival (p-value = .00771 and p-value = .00293). The highest area under receiver operating characteristic (ROC) curve was 0.8212 for the combination of miR-652-5p and miR-7-2-3p. Collectively, our findings demonstrated that the miR-652-5p/miR-7-2-3p signature may serve as a promising prognostic marker in patients with locally advanced EAC.


Surgical Endoscopy and Other Interventional Techniques | 2018

Sep70/Pepsin expression in hypopharynx combined with hypopharyngeal multichannel intraluminal impedance increases diagnostic sensitivity of laryngopharyngeal reflux

Toshitaka Hoppo; Ali H. Zaidi; Daisuke Matsui; Samantha Martin; Yoshihiro Komatsu; Emily J. Lloyd; Juliann E. Kosovec; Albert A. Civitarese; Natalie H. Boyd; Amit Shetty; Ashten N. Omstead; Emily Smith; Blair A. Jobe

BackgroundImproved methods of diagnosis of laryngopharyngeal reflux (LPR) would enable surgeons to better identify patients who may benefit from antireflux surgery (ARS). The objective of the present study was to assess if hypopharyngeal Pepsin and Sep70 expression combined with hypopharyngeal multichannel intraluminal impedance (HMII) has the potential to increase diagnostic sensitivity of LPR.MethodsThis study was performed on patients who underwent unsedated transnasal endoscopy with hypopharyngeal biopsy and 24-h HMII to determine abnormal proximal exposure (APE) and DeMeester score (DMS) from 2013 to 2016. Pepsin and Sep70 protein expression was assessed by Western blots of biopsy specimens. The outcomes of ARS were assessed using reflux symptom index (RSI). HMII APE classification, Sep 70, and Pepsin protein levels were compared in normative and symptomatic LPR patients and further analyzed alongside quality of life changes following ARS.ResultsOf 30 subjects enrolled, 23 were excluded for abnormal HMII results or endoscopic evidence of esophagitis. Seven subjects and 105 patients were included in the normative and symptomatic groups, respectively. Compared to the normative group, only Pepsin expression was significantly higher in the symptomatic group [APE+/LPR+ (p = 0.000), APE+/LPR− (p = 0.001), and APE− (p = 0.047)]. Further, the ratio of Sep70/Pepsin was significantly lower in the symptomatic group [APE+/LPR+ (p = 0.008), APE+/LPR− (p = 0.000), and APE− (p = 0.050)], and a cutoff ratio for a diagnosis of LPR was established as < 158. Of 105 symptomatic patients, 48 patients underwent ARS. Of these, 17 patients had complete pre- and post-RSI questionnaires. LPR symptoms improved in 15 (88%), of whom 2 were APE− but met criteria for a diagnosis of LPR based on the Sep70/Pepsin cutoff.ConclusionsThe identified Sep70/Pepsin ratio may serve as a reliable biomarker for the diagnosis of LPR. As a result, this may help identify additional patients who have a false-negative HMII result due to the 24-h testing window.


Cancer Investigation | 2018

Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development

Ashten N. Omstead; Juliann E. Kosovec; Daisuke Matsui; Samantha Martin; Matthew A. Smith; D. Aaron Guel; Jenna Kolano; Yoshihiro Komatsu; Fahim Habib; Christopher Lai; Kevi Christopher; Ronan J. Kelly; Ali H. Zaidi; Blair A. Jobe

Abstract A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett’s with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.


Gastroenterology | 2018

Su1160 - Improvements in Quality of Life and Objective Patient Characteristics are Seen after Magnetic Sphincter Augmentation

Kirsten Newhams; Anne Meslang; Adam Alleyne; Samantha Martin; Kristy Chovanec; Philip Jackson; Emily Smith; Ali H. Zaidi; Blair A. Jobe


Gastroenterology | 2018

Mo1009 - Magnetic Sphincter Augmentation Improves Lower Esophageal Sphincter Pressure while Maintaining Esophageal Function

Kirsten Newhams; Anne Meslang; Adam Alleyne; Samantha Martin; Kristy Chovanec; Philip Jackson; Emily Smith; Ali H. Zaidi; Blair A. Jobe


Journal of Clinical Oncology | 2017

Magnitude and duration of immune checkpoint up-regulation and changes in the immune microenvironment post chemo-radiation (CRT) in esophageal cancer.

Ronan J. Kelly; Ali Hussainy Zaidi; Matthew A. Smith; Ashten N. Omstead; Juliann E. Kosovec; Daisuke Matsui; Samantha Martin; Christina DiCarlo; E. Day Werts; Jan Silverman; David H. Wang; Blair A. Jobe


Journal of Clinical Oncology | 2017

Antitumor efficacy of CDK 4/6 dual inhibitor, abemaciclib, in an esophageal adenocarcinoma model.

Ashten N. Omstead; Daisuke Matsui; Juliann E. Kosovec; Samantha Martin; Ronan J. Kelly; Ali Hussainy Zaidi; Blair A. Jobe


Journal of Clinical Oncology | 2017

Implementation of a multidisciplinary quality improvement initiative to improve molecular testing rates in advanced non-squamous non-small cell lung cancer.

Zachary Otaibi; Rohit Rao; Matthew Bartock; Mamatha Gaddam; Samantha Martin; Gene Grant Finley


Journal of Clinical Oncology | 2017

Checkpoint expression pre and post chemoradiation in operable esophageal cancer.

Ronan J. Kelly; Ali H. Zaidi; Matthew R. Smith; Ashten N. Omstead; Juliann E. Kosovec; Daisuke Matsui; Samantha Martin; Gene Grant Finley; Jan F. Silverman; E. Day Werts; Blair A. Jobe


Gastroenterology | 2017

Effect of Anti-Reflux Surgery (ARS) on Symptom Resolution and Quality of Life (QOL) in Patients with Laryngopharyngeal Reflux (LPR) who Fail Medical Therapy

Fahim Habib; Ali H. Zaidi; Yoshihiro Komatsu; Emily J. Lloyd; Samantha Martin; Emily Smith; Blair A. Jobe; Toshitaka Hoppo

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Blair A. Jobe

Allegheny Health Network

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Ali H. Zaidi

Allegheny Health Network

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Ronan J. Kelly

Johns Hopkins University

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Daisuke Matsui

Toyama Prefectural University

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Emily Smith

Allegheny Health Network

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Emily J. Lloyd

Allegheny Health Network

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Fahim Habib

Allegheny Health Network

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