Samantha Swindell

Common Processes May Contribute to Extinction and Habituation

Abstract Psychologists routinely attribute the characteristics of conditioned behavior to complicated cognitive processes. For example, many of the characteristics of behavior undergoing extinction have been attributed to retrieval from memory. The authors argue that these characteristics may result from the simpler process of habituation. In particular, conditioned responding may decrease during extinction partially because habituation occurs to the stimuli that control responding when those stimuli are presented repeatedly or for a prolonged time (e.g., the experimental context, the conditioned stimulus in classical conditioning). This idea is parsimonious, has face validity, and evokes only processes that are well established by other evidence. In addition, behavior undergoing extinction shows 12 of the fundamental properties of behavior undergoing habituation. However, this model probably cannot provide a complete theory of extinction. It provides no obvious explanation for some of the other characteristics of extinguished behavior.

Repeated Formaldehyde Effects in an Animal Model for Multiple Chemical Sensitivity

Abstract: Chemical intolerance is a phenomenon observed in multiple chemical sensitivity (MCS) syndrome, an ill‐defined disorder in humans attributed to exposure to volatile organic compounds. Amplification of symptoms in individuals with MCS resembles the phenomenon of psychostimulant‐ and stress‐induced sensitization in rodents. We have recently tested in rats the hypothesis that repeated chemical exposure produces sensitization of central nervous system (CNS) circuitry. A rat model of MCS in our laboratory has employed several endpoints of CNS function after repeated formaldehyde (Form) exposure (1 h/day × 5 days/week × 4 weeks). Repeated Form exposure produced behavioral sensitization to later cocaine injection, suggesting altered dopaminergic sensitivity in mesolimbic pathways. Rats given repeated Form also demonstrated increased fear conditioning to odor paired with footshock, implicating amplification of neural circuitry guiding fear responding to a conditioned odor cue. Recent studies examining the effects of repeated Form on locomotor activity during each daily exposure showed a decrease in rearing activity after 12‐15 days of Form exposure compared to air‐exposed controls. EEG recordings taken 1 week after withdrawal from daily Form revealed altered sleep architecture. Some of the differences in sleep disappeared after subsequent brief (15 min) challenge with Form the next day. Overall, the findings indicate that repeated low‐level chemical exposure produces behavioral changes that may be akin to those observed in individuals with MCS, such as greater sensitivity to chemicals manifest as increased anxiety upon chemical exposure and altered sleep and/or fatigue. Study of the underlying CNS changes will provide a basis for mechanistically based animal models for MCS.

On the contributions of responding and reinforcement to within-session patterns of responding

Operant responding may change systematically within experimental sessions even when the contingencies of reinforcement remain constant across the session. In two experiments, eight pigeons pecked a key for mixed grain delivered by variable interval or multiple variable interval schedules. Experiment 1 showed that changes in the rate at which reinforcers were delivered altered the within-session patterns even when the total amount of reinforcement presented per session was held constant. Experiment 2 showed that changing the overall rate of responding did not alter within-session response patterns. These results question the idea that within-session patterns of responding are produced by simple interpretations of satiation or fatigue. If within-session changes in responding were produced by satiation, then subjects receiving equal amounts of reinforcement should have shown similar within-session patterns of responding, but they did not (Experiment 1). If within-session changes were produced by fatigue, then the patterns should have differed when the overall response rate differed, but they did not (Experiment 2). The present study confirms that within-session patterns of responding are sensitive to changes in rate of reinforcement.

Repeated low level formaldehyde exposure produces enhanced fear conditioning to odor in male, but not female, rats.

Multiple chemical sensitivity (MCS) is an ill-defined disorder in humans attributed to exposure to volatile organic compounds. This study draws on apparent parallels between individuals with posttraumatic stress disorder (PTSD) and panic disorder and a subset of those reporting MCS, using a conditioned fear task in rats. Male and female Sprague-Dawley rats were given repeated exposure to 2 ppm formaldehyde (Form) (1 h/day x 5 days/week x 4 week) or air, and after 2-3 weeks, rats were trained on the conditioned fear task. One half of Air and Form rats were given odor (orange oil, the conditioned stimulus, CS) paired with footshock (PRD) and the other half was given the same stimuli in an unpaired manner (UNP). After 24 h, rats were placed into the same context without the CS or footshock. Male and female PRD groups demonstrated contextual freezing 5-15% of the time, while the UNP groups showed freezing 30-50% of the time, with no effect of Air or Form pretreatment. For the next 5 days, rats were placed into a novel context and tested for freezing in the absence or presence of the CS. In male rats, Form pretreatment produced a significantly greater freezing response in both UNP and PRD groups in the presence of the CS, with no differences in freezing in the absence of the CS. In female rats, no significant differences between Form pretreated rats and Air controls were observed in either the PRD or UNP groups. The increase in conditioned fear responding to the CS after Form exposure in males suggests that repeated low-level Form may act as a stressor to produce sensitized responding within olfactory/limbic pathways, and may help explain the panic-like responses observed in a subset of individuals reporting MCS. Furthermore, the male/female differences suggest a gonadal hormonal contribution to this behavior.

Women in applied behavior analysis.

The status of women in applied behavior analysis was examined by comparing the participation of women in the Journal of Applied Behavior Analysis (JABA) to their participation in three similar journals. For all journals, the percentage of articles with at least one female author, the percentage of authors who are female, and the percentage of articles with a female first author increased from 1978 to 1997. Participation by women in JABA was equal to or greater than participation by women in the comparison journals. However, women appeared as authors on papers in special sections of Behavior Modification substantially more often when the editor was female than when the editor was male. In addition, female membership on the editorial boards of JABA, Behavior Modification, and Behaviour Research and Therapy failed to increase from 1978 to 1997. We conclude that a “glass ceiling” reduces the participation of women at the highest levels of applied behavior analysis and related fields.

Reinforcer value may change within experimental sessions

Large and systematic changes in response rates often occur within sessions during operant conditioning procedures. In the present experiment, we asked whether the value of the reinforcer that supports responding also changes within sessions. Pigeons pecked a key for mixed grain available throughout the session. Occasionally, wheat was also provided for pecking a second key. The ratio of the rates of responding for mixed grain and wheat, a frequently used measure of relative reinforcer value, changed significantly within sessions when mixed grain was provided at high, but not at low, rates. Habituation to the reinforcer provides the most likely explanation for these changes in reinforcer value. Eventually, habituation may provide a unified explanation for the within-session changes in behavior that occur when many species of subjects respond on a wide variety of tasks.

Within-session patterns of responding when the operandum changes during the session

Eight pigeons and 10 rats responded on variable interval 1-min or variable interval 30-s schedules. During baseline, the same operandum produced reinforcers throughout the session. During the switch conditions, performing one response produced reinforcers early in the session and performing a different response produced reinforcers later. The switch between the two responses occurred 10, 20, 30, or 40 min into the session in different conditions. Within-session patterns of responding were not usually different when the same operandum produced reinforcers throughout the session and when the operandum changed from the right to the left key (pigeons) or lever (rats). Changes from a treadle to a key (pigeons) or from a lever to a key (rats) also failed to alter within-session patterns of responding. These results suggest that factors related to the form of the instrumental response (e.g., muscular warm-up, fatigue) contributed little to within-session changes in responding under the present circumstances.

Prospective factors contribute little to within-session changes in responding

Five rats pressed levers for food delivered by a multiple variable interval 1-min variable interval 1-min schedule. In theunpredictable conditions, sessions were 20, 40, 60, 80, or 100 min long, determined randomly at the beginning of each session. In thepredictable conditions, each of these session durations was presented for 15 consecutive sessions. Rate of responding changed systematically within the session even when the end of the session was unpredictable. This implies that prospective factors related to anticipation of the end of the session are not necessary for producing withinsession changes in responding. Within-session patterns of responding were also similar for the predictable and unpredictable conditions. This suggests that prospective factors contributed little to the form of the within-session patterns under the present conditions.

Women in the experimental analysis of behavior

We examined the status of women in the experimental analysis of behavior by comparing authorship by women in the Journal of the Experimental Analysis of Behavior (JEAB) to authorship by women in three similar journals. For all journals, the percentage of articles with at least one female author, the percentage of authors who are female, and the percentage of articles with a female first author increased from 1978 to 1997. However, the participation by women in JEAB lagged behind participation in the other journals on each measure. Female membership on the editorial board of JEAB also failed to increase from 1978 to 1997. Suggestions are made that may increase the participation of women in the experimental analysis of behavior.

Within-session changes in responding during delayed matching-to-sample and discrimination procedures

Two experiments examined within-session changes in responding during discrimination procedures. In Experiment 1, rate of responding changed significantly within sessions during symbolic delayed matching-to-sample tasks when the delay between the stimulus and the choice period was short (1–5 sec), but not when it was long (8–12 sec). The percentage of responses that were correct did not change within sessions. In Experiment 2, response rates increased and then decreased within sessions during both S1 and S2 when successive discrimination procedures provided high, but not low, rates of reinforcement. Discrimination ratios sometimes increased within sessions. These results question two potential definitions of attention as explanations for within-session changes in response rates. They are more compatible with explanations based on concepts such as arousal, satiation, habituation, and interfering responses.