Sameera Husain

Resolution of urticarial vasculitis after treatment of neurocysticercosis.

in January 2014, complete remission was sustained. However, a right side submandibular mass of about 2 3 2 cm was noted incidentally in June 2013. Computed tomography revealed a cystlike lesion. The patient and family refused further evaluation of themass. The size of themass was unchanged during 6 months of follow-up. IAC has the advantage of delivering a high concentration of drug to the lesion. Studies by Harker and Stephen showed that a greater concentration of 5-FU in the tumor region is achieved by intra-arterial than by intra-venous administration. In studies by Claudio et al after IAC, 87.5% of the carcinoma of the facial skin attained resectability. However, none of the cases was an adenocarcinoma. IAC has potential for the treatment of refractory neoplasms, and may have advantages in terms of cosmetic and functional preservation.

Lethal T‐ and NK‐cell lymphomas mimicking granulomatous panniculitidies: a clinicopathologic study of three cases

An infiltrate mimicking subcutaneous panniculitis associated with a granulomatous response represents an uncommon histopathologic presentation of lymphoma. We report three cases, comprising one case each of nasal‐type extranodal NK/T‐cell lymphoma, cutaneous γ/δ T‐cell lymphoma and human T‐lymphotropic virus‐I associated adult T‐cell leukemia/lymphoma, which based on initial histopathologic and/or clinical presentation were thought to represent systemic lupus erythematosus, sarcoidosis and psoriasiform dermatitis, respectively. Excisional biopsies of indurated lesions performed at our institute; however, in each case showed an atypical subcutaneous lymphohistiocytic infiltrate associated with a variable number of granulomas. Extensive immunophenotypic characterization, in conjunction with histomorphologic and molecular analysis, established the diagnosis of lymphoma in all instances. All patients had a rapidly progressive clinical course and death was attributable to complications of lymphoma shortly after diagnosis. These cases highlight the importance of using a multimodality diagnostic approach to distinguish lymphomas masquerading as granulomatous panniculitis from inflammatory or reactive disorders associated with such histopathologic patterns.

Papular acantholytic dyskeratosis of the genitocrural area: A rare unilateral asymptomatic intertrigo

Papular acantholytic dyskeratosis (PAD) of the genitocrural area is a rarely reported skin disorder in women and even less frequently reported in men. We present a case of PAD localized to the inguinal fold of a 78-year-old man. PAD should be added to the differential diagnosis of intertrigo.

Herpetic zoster folliculitis in the immunocompromised host

Exclusive involvement of herpes zoster (HZ) in the follicular epithelium occurs rarely and lacks the typical cutaneous and histopathologic findings associated with herpesvirus.1 We describe a patient who underwent adjuvant chemotherapy for pancreatic cancer and subsequently had a nonvesicular rash for several weeks, ultimately proving to be herpetic zoster folliculitis.

Nevus anemicus: An island of sparing in the setting of drug-induced hypersensitivity

DIHS: drug-induced hypersensitivity syndrome HHV-6: human herpes 6 virus NA: nevus anemicus NDP: nevus depigmentosus INTRODUCTION Nevus anemicus (NA) is an uncommon congenital finding characterized by a discrete area of hypopigmentation that remains stable in size throughout life. To our knowledge, generalized cutaneous eruption sparing NA in a mosaic fashion has never been reported in the literature. We report a case of erythrodermic drug-induced hypersensitivity syndrome (DIHS) in the setting of human herpes 6 virus (HHV-6) viremia, sparing NA.

Trichophyton rubrum tinea capitis in an HIV-positive patient with generalized dermatophytosis

INTRODUCTION Generalized dermatophytosis, or chronic widespread dermatophytosis, is an uncommon disease most often caused by Trichophyton rubrum in the immunocompromised or chronically ill host. Tinea capitis caused by T rubrum is rare in adult patients and has not, to our knowledge, been described in the HIV/AIDS population. We report the unusual case of a 62-year-old HIV-positive woman with generalized dermatophytosis and tinea capitis caused by T rubrum.

Delayed-onset vemurafenib-induced panniculitis

INTRODUCTION Approved in 2011, vemurafenib is a selective serine/threonine kinase inhibitor directed against the V600E mutation in the BRAF gene. This drug is often used in dermatology as a targeted therapy for metastatic or unresectable melanomas, for which about 50% have this mutation. Other tumors possessing the V600E mutation are targets for this therapy. The commonly reported adverse effects of vemurafenib include rash, squamoproliferative growths, photosensitivity, squamous cell carcinoma, milia, hand-foot skin reaction, and dry skin. Panniculitis is a rare adverse effect associated with BRAF inhibitors. To the authors’ knowledge, this is the first report of histopathologically confirmed delayed-onset vemurafenib-induced panniculitis in an adult, with the patient presenting 324 days after initiating therapy.

A case of lymphomatoid granulomatosis presenting with cutaneous lesions

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder that involves the skin in approximately 50% of cases. We describe a patient with LYG who first presented with cutaneous lesions. His skin biopsy failed to show large B-cell lymphocytes positive for Epstein-Barr virus (EBV)-encoded RNA in situ hybridization (EBER-ISH), highlighting the diagnostic challenges that dermatologists may face when encountering cutaneous LYG.

Patient with a history of indurated plaques and renal disease

Figure 2 Six years prior, biopsies performed on initial skin lesions showed a diffuse increase in fibroblasts in the upper dermis, a sparse superficial lymphocytic infiltrate and vascular ectasia (hematoxylin and eosin stain; 9100) Figure 3 Histopathology on skin lesions shown in Fig. 1. Note mild fibrosis of the dermis, a slight increase in spindle shaped cells and well-circumscribed, sclerotic appearing amorphous eosinophilic bodies in distinct foci within the upper dermis (arrow) (hematoxylin and eosin stain; 9100)