Sami Jannin

Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry

Dynamic nuclear polarization (DNP) can boost sensitivity in nuclear magnetic resonance (NMR) experiments by several orders of magnitude. This Feature illustrates how the coupling of DNP with both liquid- and solid-state NMR spectroscopy has the potential to considerably extend the range of applications of NMR in analytical chemistry.

A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T

A novel system for dissolution dynamic nuclear polarization based on a cost-effective cryogen-free magnet that can generate fields up to 9.4u202fT with a sample space that can reach temperatures below 1.4u202fK in a continuous and stable manner. Polarization levels up to P(1H)u202f=u202f60u202f±u202f5% can be reached with TEMPOL in about 20u202fmin, and P(13C)u202f=u202f50u202f±u202f5% can be achieved using adiabatic cross polarization.

Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging

Tailoring the physical features and the porous network architecture of silica-based hyperpolarizing solids containing TEMPO radicals, known as HYPSO (hybrid polarizing solids), enabled unprecedented performance of dissolution dynamic nuclear polarization (d-DNP). High polarization values up to P(1 H)=99u2009% were reached for samples impregnated with a mixture of H2 O/D2 O and loaded in a 6.7u2005T polarizer at temperatures around 1.2u2005K. These HYPSO materials combine the best performance of homogeneous DNP formulations with the advantages of solid polarizing matrices, which provide hyperpolarized solutions free of any-potentially toxic-additives (radicals and glass-forming agents). The hyperpolarized solutions can be expelled from the porous solids, filtered, and rapidly transferred either to a nuclear magnetic resonance (NMR) spectrometer or to a magnetic resonance imaging (MRI) system.

Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups

Dissolution-dynamic nuclear polarization is implemented to hyperpolarize long-lived nuclear spin states in monodeuterated methyl groups.