Sami Räsänen

Excess mortality among long-stay psychiatric patients in Northern Finland.

Abstract.Background: According to several studies, mortality in psychiatric patients is higher than in the general population, but cause-specific mortality analyses in long-stay psychiatric patients have not been studied very much. Individual follow-ups have been called for in order to identify possible treatment deficiencies and to make recommendations for clinical practices. In this study, mortality of long-stay psychiatric patients has been monitored for the years 1992–2000 and contrasted with that prevalent in the general population. Method: Data on psychiatric patients (N = 253) who were treated without a break for at least 6 months during 1992 in the Department of Psychiatry at Oulu University Hospital were linked with the National Death Register. Standardised mortality rates (SMRs) were determined according to gender, age groups, and different causes of death. Results: Of the total study population, 80.2 % had schizophrenia, 5.1 % other functional psychoses, 9.5 % organic mental disorders, 2.4 % personality disorders and 2.8 % mood disorders. Sixty-nine (27.3 %) of the patients (aged 31–88 years) had died before the end of the year 2000. The all-cause death risk for both males and females was four times that of the general population. The mortality risk was over ten-fold for males and almost 30-fold for females in the youngest age group (25–34 years), with suicides explaining about 75 % of these deaths. SMRs were found to decrease at older age, mortality thus approaching that of the general population. Diseases of the circulatory system were the most common single cause of death in both genders and mortality due to that cause exceeding mortality in the general population nearly 3.6-fold. However, the probability of death was highest (SMR 17.5) in connection with diseases of the digestive system. Increased risks of death due to respiratory complications (SMR 9.3), accidents (SMR 5.1) and neoplasms (SMR 2.1) were also noted. The overall death rates did not differ in relation to social class or professional education. Conclusions: Long-stay psychiatric patients were found to die from the same natural causes as the rest of the general population. However, the mortality risk of the long-stay psychiatric patients compared with that of the general population was notably higher, despite ongoing improvements in medical care and facilities. Inadequately organised somatic care and the prevailing culture of “non-somatic” treatment in psychiatry were suggested to, at least in part, explain this phenomenon. Attention ought to increasingly focus on somatic examinations and various health educational programmes specially designed for psychiatric patients and involving matters like healthy diet, smoking cessation and physical exercise. These practices should be a regular part of any patients treatment programme. Also, the need to recognise factors associated with a patients psychiatric disorder that could limit that patients ability to communicate somatic symptoms and/or even lead to a refusal by that patient to have somatic diseases treated was seen as essential for providers of psychiatric services.

A systematic narrative review of the studies on structured child‐centred interventions for families with a parent with cancer

Objective: To perform a systematic narrative review of the current state of published articles on the structured interventions targeted at children with a parent suffering from cancer.

Sex differences in schizophrenia: A review

During the past decade schizophrenia research has emphasized the importance of sex differences. Most studies have found that lifetime risk of schizophrenia has been equally common in both sexes. Men develop schizophrenia 3-4 years earlier than women, regardless of culture, but late-onset schizophrenia has been found to be commoner in women. Women more often have a favorable course of schizophrenia than men: they experience fewer and shorter hospitalizations, survive longer in the community, and also have better social functioning. Men more often have chronic and more severe forms of schizophrenia, they have negative symptoms more often, and their doses of neuroleptic medication are higher. Men with schizophrenia tend to have more central nervous system abnormalities than women. In the future it is important to study factors that have been observed in sex differences, heredity, and brain physiology as they relate to schizophrenia. Sex differences as they relate to treatment programs are important both from...During the past decade schizophrenia research has emphasized the importance of sex differences. Most studies have found that lifetime risk of schizophrenia has been equally common in both sexes. Men develop schizophrenia 3-4 years earlier than women, regardless of culture, but late-onset schizophrenia has been found to be commoner in women. Women more often have a favorable course of schizophrenia than men: they experience fewer and shorter hospitalizations, survive longer in the community, and also have better social functioning. Men more often have chronic and more severe forms of schizophrenia, they have negative symptoms more often, and their doses of neuroleptic medication are higher. Men with schizophrenia tend to have more central nervous system abnormalities than women. In the future it is important to study factors that have been observed in sex differences, heredity, and brain physiology as they relate to schizophrenia. Sex differences as they relate to treatment programs are important both from a scientific perspective and from a practical point of view.

Avoidable mortality in long-stay psychiatric patients of Northern Finland

The aim of the present study was to examine mortality due to avoidable and unavoidable causes, unnatural deaths, and mortality possibly related to the use of psychotropic drugs. Mortality of 253 long-stay psychiatric patients from Northern Finland were monitored over a 9-year period and characterized according to standardized mortality rates (SMRs). Deaths due to avoidable causes included about 30% of all deaths, SMRs being 1.9 times (males) and 3.2 times (females) higher than those of the general population. The risk of unnatural deaths was also elevated, with SMRs amounting to 3.9 in males and 8.5 in females. An increased mortality risk, possibly related to the use of psychotropic drugs, was noticed. The physical care of long-stay psychiatric patients seems not to reach the same level that the general population enjoys. Continuous attention to the physical health of psychiatric patients is important, but new strategies and specific intervention methods should not be neglected. The concept of “avoidable mortality” is a useful, but rarely used indicator of the quality of the medical care in psychiatric populations. However, the concept needs regular updates from the whole field of medicine. From the psychiatric point of view, it was suggested that suicides be regarded as avoidable deaths.

Genetic vulnerability and premature death in schizophrenia spectrum disorders: a 28-year follow-up of adoptees in the Finnish Adoptive Family Study of Schizophrenia.

Background: Excess mortality is widely reported among schizophrenia patients, but rarely examined in adoption study settings. Aim: We investigated whether genetic background plays a role in the premature death of adoptees with schizophrenia. Methods: Mortality among 382 adoptees in the Finnish Adoptive Family Study of Schizophrenia was monitored from 1977 to 2005 through the national causes-of-death register. The sample covered 190 adoptees with a high genetic risk of schizophrenia (HR) and 192 with a low risk (LR). Results: Overall mortality among the adoptees did not differ between the HR and LR groups, as 10% and 9% respectively had died during the follow-up, at mean ages of 45 and 46 years. Schizophrenia spectrum disorder was the most significant predictor of premature death in both groups, with dysfunction in the rearing family environment associated with mortality, unnatural deaths and suicides in the HR but not in the LR group. All the suicides involved HR cases. Conclusions: Mortality among the adoptees was not related to genetic factors but to environmental ones. The association of unnatural deaths and suicides with dysfunction in the rearing environment among the HR adoptees may indicate that they had a greater genetically determined vulnerability to environmental effects than their LR counterparts. The genetic and rearing environments can be disentangled in this setting because the biological parents give the offspring their genes and the adoptive parents give them their rearing environment. Our findings add to knowledge of the factors associated with the premature death of adoptees in mid-life.

Mental disorder diagnoses of offspring affected by parental cancer before early adulthood: the 1987 Finnish Birth Cohort study

The purpose of this study is to investigate psychiatric diagnoses given to children affected by parental cancer in psychiatric and somatic specialized health care settings.

Parents' traumatic brain injury increases their children's risk for use of psychiatric care: the 1987 Finnish Birth Cohort study

OBJECTIVE Traumatic brain injury (TBI) of a parent causes significant changes in their family life and parent-children relationships. However, the number of children affected by parental TBI and the long-term consequences for these children remain unknown. We estimated the prevalence of children affected by parental TBI and investigated whether these children had greater use of psychiatric services than their peers. METHODS This a retrospective population-based register study. All 60,069 children born in Finland in 1987 were followed up through national health and social registers from 1987 to 2008. RESULTS During the 21-year follow-up, 1532 (2.6%) children had a parent with TBI. Overall, 22.5% of those having a parent with TBI were treated in specialized psychiatric care. Use of psychiatric care was significantly increased among those cohort members with a parent with mild [odds ratio (OR) 1.80, 95% confidence interval (CI) 1.37-2.38] or severe (OR 1.49, 95% CI 1.12-1.98) TBI compared to their peers. CONCLUSIONS Parental TBI is associated with increased use of specialized psychiatric services by children. Adult health care services must have appropriate systems in place to address the psychosocial needs and support the welfare and development of children of patients with TBI.

Gender differences in treatment and outcome in a therapeutic community ward, with special reference to schizophrenic patients.

This study examines gender differences in treatment and institutional outcome in a closed mixed-psychiatric ward functioning as a therapeutic community. Its first-time male (n = 784) and female (n = 741) patients were classified into five diagnostic categories according to criteria from the third revised edition of the Diagnostic and Statistical Manual of Mental Disorders: schizophrenia, schizophreniform/schizoaffective disorder, other psychoses, mood disorders, and nonpsychotic disorders. There were no statistically significant gender differences in sociodemographic variables either in the length of stay or in the number of treatment episodes in this ward in any diagnostic group. Differences in male and female participation in psychosocial therapies (individual, group, and milieu therapy) and in institutional outcome were minimal, with a slight trend in favor of the females. These minimal gender differences indicate an achievement of the treatment goals, and of achieving intergender equality. These goals are especially important for schizophrenic males due to their more severe clinical profile and poorer prognosis. With its greater degree of interaction and positive experiences, the therapeutic community model may help psychotic male patients in facing their age- and gender-specific life-span challenges.

Parental hospital-treated somatic illnesses and psychosis of the offspring-The Northern Finland Birth Cohort 1986 study

The aim of this study was to investigate whether parental somatic illnesses during childhood increase the risk for later psychosis in the offspring. In addition, we examined which parental illnesses in particular are associated with increased risk of psychosis in the offspring.

Association between parental hospital-treated somatic illnesses in childhood and later mental disorders among offspring up to early adulthood: An explorative study in the 1987 Finnish Birth Cohort

Aims: Earlier studies on the associations between parental somatic illnesses and children’s psychological wellbeing have focused on the most common somatic illnesses or on specific groups of illnesses. In this study, we aimed to systematically examine whether parental somatic illnesses, diagnosed during an offspring’s childhood, are associated with later mental disorders of the offspring and, if so, identify which parental somatic illnesses in particular increase the likelihood for later mental disorders among the offspring. Methods: The 1987 Finnish Birth Cohort study yields longitudinal nationwide follow-up data that include a complete census of children born in a single year. Children have been followed over time through to the year 2012 using official registers maintained by the Finnish authorities. Parental diagnoses of specialised hospital inpatient care were identified from the Hospital Discharge Register after children’s birth and followed up until the end of 1995. Children’s psychiatric diagnoses from specialised hospital care were identified from the same register for the periods 1996/1998–2012. Logistic regression analyses were used to calculate sex-specific odds ratios for associations of mental disorders with maternal and paternal somatic illnesses using parental death, education, social assistance and psychiatric inpatient care as covariates. Results: Parental somatic illnesses during an offspring’s childhood seem to increase the risk for later mental disorders. Several previously unreported somatic parental illnesses were found to be significantly associated with offspring’s later mental health. Conclusions: Parental somatic illnesses should be considered as a significant adverse childhood life event, calling for preventive actions and child-centred support in adult healthcare.