Samuel Phillips

Adrenocortical steroid therapy and chemotherapy in acute, far-advanced toxic pulmonary tuberculosis

Abstract 1. 1. Four cases of acute, far-advanced pulmonary tuberculosis with organisms susceptible to antimicrobial agents and complicated by persistence of toxicity, fever, and failure to show improvement, or worsening, or standard antimicrobial therapy, are reported. One case had definite adrenocortical hypofunction. 2. 2. Adrenocortical steroids were given as adjunctive therapy to these cases, following which there appeared to be an accelerated improvement, clinically, radiographically, and hematologically in all four cases, and bacteriologically in three, There was one death in the series and it is possible that steroid therapy may have been a contributory factor. 3. 3. The pertinent literature is reviewed.

Preliminary report on the serial EEGs fo pulmonary tuberculous patients treated with isoniazid

Abstract Serial electroencephalograms were obtained on 52 cases of tuberculosis treated with isoniazid in combination with other antimicrobial therapy. There were no observable changes in the 166 electroencephalograms as compared with the normal or abnormal records prior to therapy. No signs of symptoms developed which could be attributed to brain involvement.