Samy M. El-Megharbel

Synthesis, chemical identification, antioxidant capacities and immunological evaluation studies of a novel silver(I) carbocysteine complex.

A new silver-carbocysteine (Ccy-Ag) complex [Ag2(Ccy)2(H2O)2] has been synthesized and characterized by using a combination of FTIR, Raman, molar conductivity, (1)H NMR, electronic spectra, thermal analyses, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The infrared spectrum of Ccy-Ag complex in comparison with carbocysteine ligand prove that Ccy behaves as monobasic bidentate chelate to the silver metal ions via the deprotonated carboxylate O atom. The assessments of Ccy and its complexation with Ag(+) in treating COPD, evaluating immune activities through measuring IL-8, TGF-β1, VEGF and TNF-α, antioxidant activities of (Ccy-Ag) complex by measuring SOD, MDA and GPX and bronchial asthma were discussed.

Preparation, spectroscopic, thermal, antihepatotoxicity, hematological parameters and liver antioxidant capacity characterizations of Cd(II), Hg(II), and Pb(II) mononuclear complexes of paracetamol anti-inflammatory drug

Keeping in view that some metal complexes are found to be more potent than their parent drugs, therefore, our present paper aimed to synthesized Cd(II), Hg(II) and Pb(II) complexes of paracetamol (Para) anti-inflammatory drug. Paracetamol complexes with general formula [M(Para)2(H2O)2]·nH2O have been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), (1)H NMR, electronic spectral studies. The conductivity data of these complexes have non-electrolytic nature. Comparative antimicrobial (bacteria and fungi) behaviors and molecular weights of paracetamol with their complexes have been studied. In vivo the antihepatotoxicity effect and some liver function parameters levels (serum total protein, ALT, AST, and LDH) were measured. Hematological parameters and liver antioxidant capacities of both Para and their complexes were performed. The Cd(2+)+Para complex was recorded amelioration of antioxidant capacities in liver homogenates compared to other Para complexes treated groups.

Synthesis, spectroscopic and thermal studies of Mg(II), Ca(II), Sr(II) and Ba(II) diclofenac sodium complexes as anti-inflammatory drug and their protective effects on renal functions impairment and oxidative stress.

The main task of our present study is the preparation of newly complexes of Mg(II), Ca(II), Sr(II) and Ba(II) with diclofenac which succeeded to great extent in alleviating the side effects of diclofenac alone and ameliorating the kidney function parameters and antioxidant capacities with respect to diclofenac treated group alone. The Mg(II), Ca(II), Sr(II) and Ba(II) with diclofenac have been synthesized and characterized using infrared, electronic and (1)H NMR spectral, thermogravimetric and conductivity measurements. The diclofenac ligand has been found to act as bidentate chelating agent. Diclofenac complexes coordinate through the oxygens of the carboxyl group. The molar ratio chelation is 1:2 (M(2+)-dic) with general formula [M(dic)2(H2O)2]⋅nH2O. Antibacterial screening of the alkaline earth metal complexes against Escherichia coli (Gram-ve), Bacillus subtilis (Gram+ve) and anti-fungal (Asperagillus oryzae, Asperagillus niger, Asperagillus flavus) were investigated. The kidney functions in male albino rats were ameliorated upon treatment with metal complexes of dic, which are represented by decreasing the levels of urea and uric acid to be located within normal values. The other looks bright spot in this article is the assessment of antioxidant defense system including SOD, CAT and MDA with the help of Sr(2+), Mg(2+) and Ca(2+)-dic complexes. The hormones related to kidney functions and stresses have been greatly ameliorated in groups treated with dic complexes in comparable with dic treated group.

Spectroscopic, structural characterizations and antioxidant capacity of the chromium (III) niacinamide compound as a diabetes mellitus drug model

New binuclear chromium (III) niacinamide compound with chemical formula [Cr2(Nic)(Cl)6(H2O)4]·H2O was obtained upon the reaction of chromium (III) chloride with niacinamide (Nic) in methanol solvent at 60°C. The proposed structure was discussed with the help of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-vis.), magnetic calculations, thermogravimetric analyses (TG/TGA), and morphological studies (X-ray of solid powder and scan electron microscopy. The infrared spectrum of free niacinamide in comparison with its chromium (III) compound indicated that the chelation mode occurs via both nitrogen atoms of pyridine ring and primary -NH2 group. The efficiency of chromium (III) niacinamide compound in decreasing of glucose level of blood and HbA1c in case of diabetic rats was checked. The ameliorating gluconeogenic enzymes, lipid profile and antioxidant defense capacities are considered as an indicator of the efficiency of new chromium (III) compound as antidiabetic drug model.

Synthesis and molecular structure of moxifloxacin drug with metal ions as a model drug against some kinds of bacteria and fungi

Metal complexes of antibiotic molecules can be used as antimicrobial mimetic drug models. The current study is devoted to the synthesis, physicochemical properties, computational, and antimicrobial activity of the products of chelation of moxifloxacin hydrochloride (mox-HCl) antibiotic drug and metal ions including Ca(II), Mg(II), Zn(II), and Fe(III). Structures of the complexes were elucidated on the basis of elemental analyses, electronic, IR, Raman, and 1H NMR spectra. The data revealed that chelation of moxifloxacin could follow mono and bidentate pathways. Ca(II), Zn(II) and Fe(III) ions coordinated via N atoms of the piperidyl ring but Mg(II) coordinated via oxygen atoms of the carbonyl (quinolone) and carboxylic groups. According to molar conductance data the complexes had non-electrolyte nature. Formulas of the complexes can be presented as [Mg(mox-HCl)2(Cl)2]·2H2O (1), [Ca(mox-HCl)2(Cl)2]·2H2O (2), [Zn(mox-HCl)2(NO3)2] (3), and [Fe(mox-HCl)3(Cl)3] (4). All synthesized mox-HCl complexes demonstrated some antibacterial but no antifungal activities.

Synthesis, spectroscopic, structural and thermal characterizations of vanadyl(IV) adenine complex prospective as antidiabetic drug agent

The vanadyl(IV) adenine complex; [VO(Adn)2]⋅SO4; was synthesized and characterized. The molar conductivity of this complex was measured in DMSO solution that showed an electrolyte nature. Spectroscopic investigation of the green solid complex studied here indicate that the adenine acts as a bidentate ligand, coordinated to vanadyl(IV) ions through the nitrogen atoms N7 and nitrogen atom of amino group. Thus, from the results presented the vanadyl(IV) complex has square pyramid geometry. Further characterizations using thermal analyses and scanning electron techniques was useful. The aim of this paper was to introduce a new drug model for the diabetic complications by synthesized a novel mononuclear vanadyl(IV) adenine complex to mimic insulin action and reducing blood sugar level. The antidiabetic ability of this complex was investigated in STZ-induced diabetic mice. The results suggested that VO(IV)/adenine complex has antidiabetic activity, it improved the lipid profile, it improved liver and kidney functions, also it ameliorated insulin hormone and blood glucose levels. The vanadyl(IV) complex possesses an antioxidant activity and this was clear through studying SOD, CAT, MDA, GSH and methionine synthase. The current results support the therapeutic potentiality of vanadyl(IV)/adenine complex for the management and treatment of diabetes.

Complexes of nalidixic acid with some vital metal ions: Synthesis, chemical structure elucidation, and antimicrobial evaluation

Complexes of nalidixic acid with Ca(II), Mg(II), Zn(II), Fe(III), and VO(II) ions, have been synthesized and characterized by means of microanalysis, conductance, IR, NMR and UV-Vis spectroscopy and thermogravimetric (TGA/DTG and DTA) measurements. The ligand coordinates in a bidentate mode via one carboxylate oxygen atom and the oxygen atom of the pyridine carbonyl group. The kinetic thermodynamic parameters such as: activation energy E*, ΔH*, ΔS*, and ΔG* have been estimated using Coats and Redfern as well as Horowitz-Metzger equations. Antimicrobial activity of the obtained complexes against some kinds of bacteria and fungi has been evaluated.

Synthesis of uranyl(II), vanadyl(II) and zirconyl urate complexes, spectral, thermal and biological studies.

Three urate chelations were obtained when uric acid was reacted with UO2(CH3COO)2H2O, VOSO4·XH2O and ZrOCl2·XH2O salts with neutralized with 0.1 M NaOH aqueous media. The 1:2 metal-to-ligand complexes [(UO2)2(C5H2N4O3)2](H2O), [(ZrO)2(H2O)2(C5H2N4O3)2] and [VO((C5H3N4O3)2] were characterized by elemental analyses, molar conductivity, (infrared, Raman and UV-vis) spectra, effective magnetic moment in Bohr magnetons, and thermal analysis (TG/DTG). The urate ligand coordinates as mononegative bidentate donor towards the mononuclear central vanadium atom and coordinated as binegative tetradentate mode towards the binuclear dioxouranium and zirconyl centers. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with uric acid. The ligand, ZrO(II) and UO2(II) complex showed a week potential degradation on calf thymus DNA, whereas VO(II) complex slightly degraded the DNA.

Synthesis of several new lanthanide Glimepiride complexes for evaluation of microbial activity

The complexation between lanthanide metal ions like Nd(III), Tb(III), and Er(III) with Glimepiride produces 1: 1 molar ratio (metal: Glimepiride) monodentate complexes of general formula: [M(GMP)(H2O)4]Cl3·xH2O, where: M = Nd, Tb, and Er, x = 1, 10, respectively. The structures of obtained compounds were assigned by IR, 1H NMR and UV/Vis spectra. Themogravimetric analysis and kinetic thermodynamic parameters have proved the thermal stability of Glimepiride complexes. Obtained lanthanide complexes showed significant effect against some bacteria and fungi.

Synthesis, spectral, antimicrobial, and thermal properties of Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) gliclazide complexes

The complexation between the lanthanide metal ions Ce(III), Gd(III), Nd(III), Tb(III), and Er(III) and gliclazide produced 1 : 1 molar ratio metal: gliclazide (Glz) complexes coordinated in a monodentate fashion via the OH group and having the general formulas [M(Glz)Cl3(H2O)]·xH2O (M = Ce, Gd, Nd and x = 1, 3, 4, respectively) and [M(Glz)(H2O)4]Cl3·yH2O (M = Tb, Er and y = 1, 2, respectively). The structure of the synthesized lanthanide gliclazide complexes was assigned by IR, 1HNMR, and UV-Vis spectroscopy. Thermal analysis and kinetic and thermodynamic parameters gave evidence for the thermal stability of the Glz complexes. The latter showed a significant antimicrobial effect against some bacteria and fungi.