Sandeep Nair

Prevalence of atrial fibrillation in an urban population in India: the Nagpur pilot study

Objectives Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice with major public health impact mainly due to the increased risk of stroke. The recent Global Burden of Disease Study reported a lack of prevalence data from India. Our goal was to conduct a pilot study to evaluate the feasibility of assessing AF prevalence and stroke prophylaxis in an urban Indian community. Methods A screening camp was conducted in Nagpur, India, that evaluated adults aged ≥18 years. We collected demographics, recorded blood pressure, height, weight and the 12-lead electrocardiogram (ECG). The presence of diabetes and hypertension was recorded by self-reported history. Patients diagnosed with AF were evaluated further to assess aetiology and management. Results Of the total 4077 randomly selected, community-dwelling adults studied, 0.196% (eight patients) were found to have AF. Mean age of the population was 43.9±14.8, and 44.5% were female. The mean age of the patients with AF was 60.5±15.8 years (five females). Rheumatic heart disease was found in five patients with AF. Three patients had history of stroke (37.5%) and one had peripheral arterial thrombosis. Three patients were on warfarin, but without routine international normalised ratio (INR) monitoring. One patient was on aspirin. Five patients were on β-blockers and one on both β-blocker and digoxin. Conclusions The prevalence of AF was low compared with other regions of the world and stroke prophylaxis was underused. A larger study is needed to confirm these findings. This study demonstrates that larger evaluations would be feasible using the community-based techniques employed here.

Population Burden of Sudden Death Associated With Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a genetically transmitted cardiac disease, characterized by increased left ventricular (LV) wall thickness in the absence of abnormal loading conditions.1 The estimated prevalence of HCM is ≈1 per 500 in the general population,2 with a diverse clinical course including heart failure and sudden cardiac arrest (SCA), but also asymptomatic survival to normal life expectancy.3 SCA attributable to ventricular arrhythmias is a major cause of mortality in young and middle-aged patients with HCM.4 With modern management strategies, including implantable cardioverter-defibrillator therapy for high-risk individuals, contemporary disease-related mortality has been reported to be ≈0.5% annually.4 These estimates are derived from several HCM patient registries, representing a somewhat selected patient population. However, the absence of symptoms causes HCM to remain undetected in a large proportion of patients. Because few data exist on the burden of HCM-related SCA in the community, in the present study we assessed the incidence and characteristics of HCM-related SCA in the young and middle-aged general population from the ongoing Oregon SUDS (Oregon Sudden Unexpected Death Study). This study was approved by the institutional review boards of Cedars-Sinai Medical Center, Oregon Health …

Risk Factors of Sudden Cardiac Death in the Young: Multiple-Year Community-Wide Assessment

Background: Prevention of sudden cardiac arrest (SCA) in the young remains a largely unsolved public health problem, and sports activity is an established trigger. Although the presence of standard cardiovascular risk factors in the young can link to future morbidity and mortality in adulthood, the potential contribution of these risk factors to SCA in the young has not been evaluated. Methods: We prospectively ascertained subjects who experienced SCA between the ages of 5 and 34 years in the Portland, Oregon, metropolitan area (2002–2015, catchment population ≈1 million). We assessed the circumstances, resuscitation outcomes, and clinical profile of subjects who had SCA by a detailed evaluation of emergency response records, lifetime clinical records, and autopsy examinations. We specifically evaluated the association of standard cardiovascular risk factors and SCA, and sports as a trigger for SCA in the young. Results: Of 3775 SCAs in all age groups, 186 (5%) occurred in the young (mean age 25.9±6.8, 67% male). In SCA in the young, overall prevalence of warning signs before SCA was low (29%), and 26 (14%) were associated with sports as a trigger. The remainder (n=160) occurred in other settings categorized as nonsports. Sports-related SCAs accounted for 39% of SCAs in patients aged ⩽18, 13% of SCAs in patients aged 19 to 25, and 7% of SCAs in patients aged 25 to 34. Sports-related SCA cases were more likely to present with shockable rhythms, and survival from cardiac arrest was 2.5-fold higher in sports-related versus nonsports SCA (28% versus 11%; P=0.05). Overall, the most common SCA-related conditions were sudden arrhythmic death syndrome (31%), coronary artery disease (22%), and hypertrophic cardiomyopathy (14%). There was an unexpectedly high overall prevalence of established cardiovascular risk factors (obesity, diabetes mellitus, hypertension, hyperlipidemia, smoking) with ≥1 risk factors in 58% of SCA cases. Conclusions: Sports was a trigger of SCA in a minority of cases, and, in most patients, SCA occurred without warning symptoms. Standard cardiovascular risk factors were found in over half of patients, suggesting the potential role of public health approaches that screen for cardiovascular risk factors at earlier ages.

Device implantation for patients on antiplatelets and anticoagulants: Use of suction drain

Background and objectives Cardiovascular implantable electronic devices (CIED) are frequently implanted in patients on anti-thrombotic agents. Pocket hematomas are more likely to occur in these patients. The use of a sterile surgical drain in the pulse generator pocket site could prevent hematomas, but fear of infection precludes its use. The objective of the present study is to study the safety and efficacy of surgical drain in patients on antithrombotics undergoing CIED implantations. Methods This is a single-centre, retrospective study involving patients undergoing CIED implantations on antithrombotics (antiplatelets and anticoagulants) from August 2013 to July 2016. Patients with high risk of thromboembolism were continued on oral antithrombotics or were bridged with heparin after stopping oral antithrombotics. A sterile close wound suction drain was placed in device pockets following CIED implantations. Post procedure, pressure dressing was applied and removed after 12 h once the drain volume was less than 10 ml in 24 h. Results Sixty seven patients required surgical drain implantation. Major indications for antithrombotic use were presence of intracoronary stent, atrial fibrillation and mechanical valve replacements. The mean post-procedural hospital stay was 3 ± 0.9 days and mean overall drain was 16.6 ± 8.2 ml. At a mean follow up of 17.6 ± 8.2 months, one patient (1.4%) had pocket hematoma. There were no infections. Conclusion The use of a surgical drain in CIED implantation significantly reduces the risk of hematoma formation without increasing the risk of infection. Antithrombotic drugs can be safely continued at the time of implantation of cardiac devices.