Sandeep P. Netalkar

Design, synthesis and DNA binding activities of late first row transition metal(II) complexes of bi- functional tri - and tetratopic imines.

A series of novel Co(II), Ni(II), Cu(II) and Zn(II) complexes of tri and tetratopic hydrazones have been prepared. Ligands L(1)H(2) and L(2)H(2) were synthesized by the condensation of 2-formylphenoxyacetic acid with 2-hydrazinobenzothiazole and 2-hydroxy-3-hydrazinebenzopyrazine, respectively. The prepared complexes were characterized by the analytical and spectral techniques. All the complexes were found to be monomeric in nature with octahedral geometry. Both ligands were found to be electrochemically active in the working potential range showing single electron transfer process attributed to the deprotonation of carboxylic group of the 2-formylphenoxyacetic acid. The potency of the ligand and its complexes as antimicrobial agents has been investigated and made to interact with Escherichia coli DNA to investigate the binding/cleaving ability by absorption, hydrodynamic and electrophoresis studies.

Pyrazole-bridged late first row transition metal complexes derived from hexadentate compartmental ligand: synthesis, characterization, antibacterial activity, and DNA binding/cleavage studies

A series of binuclear CoII, NiII, CuII, and ZnII complexes having μ-1,2 diazine bridging have been prepared and characterized by various physicochemical methods. The hexadentate ligand is synthesized by condensing pyrazole-3,5-dicarbohydrazide with 2-hydroxynaphthaldehyde (LH3) in 1:2 ratio. All the complexes were found to be monomeric in nature with octahedral geometry and act as nonelectrolytes. Ligand and complexes were screened for antibacterial activity against Escherichia coli and made to interact with its DNA to investigate the binding/cleaving ability by absorption, hydrodynamic, thermal denaturation, and electrophoresis studies. An intercalative binding mode is predicted by the results. Gel electrophoresis data indicate cleavage of DNA to a greater extent by both ligand and complexes.