Sandor L. Varga
Merck & Co.
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Featured researches published by Sandor L. Varga.
Journal of Medicinal Chemistry | 1983
John J. Baldwin; Marcia E. Christy; George H. Denny; Charles N. Habecker; Mark B. Freedman; Paulette A. Lyle; Gerald S. Ponticello; Sandor L. Varga; Dennis M. Gross; Charles S. Sweet
A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for beta-adrenoceptor antagonism, and several examples were found to be selective for the beta 1-adrenoceptor. The structure--activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-4-(2 -thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the beta 1-adrenergic receptor and has been selected for in-depth studies.
Journal of Organic Chemistry | 1986
Barry M. Trost; J. L. Belletire; Stephen A. Godleski; Patrick G. McDougal; James M. Balkovec; John J. Baldwin; Marcia E. Christy; Gerald S. Ponticello; Sandor L. Varga; James P. Springer
Journal of the American Chemical Society | 1972
Daniel F. Veber; John D. Milkowski; Sandor L. Varga; Robert G. Denkewalter; Ralph Hirschmann
Journal of Medicinal Chemistry | 1999
Nigel J. Liverton; John W. Butcher; Christopher F. Claiborne; David A. Claremon; Brian Libby; Kevin Nguyen; Steven M. Pitzenberger; Harold G. Selnick; Garry R. Smith; Andrew J. Tebben; Joseph P. Vacca; Sandor L. Varga; Lily Agarwal; Kim Dancheck; Amy J. Forsyth; Daniel S. Fletcher; Betsy Frantz; William A. Hanlon; Coral Harper; Scott J. Hofsess; Matthew Kostura; Jiunn Lin; Sylvie Luell; Edward A. O'Neill; Chad Orevillo; Margaret Pang; Janey Parsons; Anna Rolando; Yousif Sahly; Denise M. Visco
Journal of the American Chemical Society | 1969
Ralph Hirschmann; Ruth F. Nutt; Daniel F. Veber; Ronald A. Vitali; Sandor L. Varga; Theodore A. Jacob; Frederick W. Holly; Robert G. Denkewalter
Journal of Medicinal Chemistry | 1987
Gerald S. Ponticello; Mark B. Freedman; Charles N. Habecker; Paulette A. Lyle; Harvey Schwam; Sandor L. Varga; Marcia E. Christy; William C. Randall; John J. Baldwin
Journal of Organic Chemistry | 1979
Stephen F. Brady; Sandor L. Varga; Roger M. Freidinger; Debra A. Schwenk; Michael Mendlowski; Frederick W. Holly; Daniel F. Veber
Archive | 1992
Keith M. Witherup; Richard W. Ransom; Sandor L. Varga; Steven M. Pitzenberger; Victor J. Lotti; William J. Lumma
Archive | 1975
Daniel F. Veber; Frederick W. Holly; Ruth F. Nutt; Sandor L. Varga
Journal of the American Chemical Society | 1969
Daniel F. Veber; Sandor L. Varga; John D. Milkowski; Henry Joshua; John B. Conn; Ralph Hirschmann; Robert G. Denkewalter
