Sandra Lorenzi
University of Bologna
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Sandra Lorenzi.
Journal of The American Academy of Dermatology | 2000
Antonella Tosti; Bianca Maria Piraccini; Sandra Lorenzi
BACKGROUND Nail invasion by nondermatophytic molds (NDM) is considered uncommon with prevalence rates ranging from 1.45% to 17. 6%. OBJECTIVE We report the clinical features and response to treatment of onychomycosis caused by these molds. METHODS From 1995 through 1998 we performed a mycologic study on 1548 patients affected by nail disorders, and we diagnosed 431 cases of onychomycosis including 59 cases of onychomycosis caused by molds. These include 17 patients with onychomycosis caused by Scopulariopsis brevicaulis, 26 patients with onychomycosis caused by Fusarium sp, 9 patients with onychomycosis caused by Acremonium sp, and 7 patients with onychomycosis caused by Aspergillus sp. RESULTS Onychomycosis caused by S brevicaulis, Fusarium sp, and Aspergillus sp may often be suspected by clinical examination. In fact 38 of 50 patients with onychomycosis resulting from these molds were affected by proximal subungual onychomycosis associated with inflammation of the proximal nailfold. In our experience mold onychomycosis is not significantly associated with systemic diseases or immunodepression. NDM are difficult to eradicate; by using and combining different treatments (systemic itraconazole, systemic terbinafine, topical terbinafine after nail plate avulsion, and ciclopirox nail lacquer) we were able to cure only 69.2% of patients with S brevicaulis onychomycosis, 71.4% of patients with Acremonium onychomycosis, and 40% of patients with Fusarium onychomycosis. Aspergillus onychomycosis, on the other hand, responded very well to therapy and all our patients were cured after systemic or topical treatment. Eradication of the mold produced a complete cure of the nail abnormalities in all the patients who responded to treatment. CONCLUSION Clinical examination usually suggests diagnosis of onychomycosis resulting from NDM. Topical treatment can be more successful than systemic therapy to cure onychomycosis caused by S brevicaulis, Fusarium sp, and Acremonium sp.
British Journal of Dermatology | 1996
Antonella Tosti; Bianca Maria Piraccini; C. Stinchi; Sandra Lorenzi
Summary Six cases of Scopulariopsis onychomycosis, including four patients with onychomycosis exclusively caused by Scopulariopsis brevicaulis and two patients with a mixed nail infection (S. brevicaulis + Tricophyton rubrum and S. brevicaulis + T. interdigitale), are reported. Four patients presented with a typical distal subungual onychomycosis characterized by subungual hyperkeratosis and onycholysis of the distal nail plate. In two patients. Scopulariopsis infection produced a total dystrophic onychomycosis associated with painful periungual inflammation. Three patients were treated with four pulses of itraconazole. 400 mg daily for 1 week a month, and three patients with terbinafine, 250 mg daily for 4 months. The mycological examination 8 months after discontinuation of treatment showed that one patient was mycologically cured whereas the remaining five patients still carried S. brevicaulis in their nails. The clinical examination at the end of the follow‐up period showed a complete cure of the nail abnormalities in only one patient.
Dermatologic Clinics | 2003
Antonella Tosti; Bianca Maria Piraccini; Sandra Lorenzi; Matilde Iorizzo
Mold onychomycosis often can be clinically suspected because of the presence of periungual inflammation. Treatment with systemic antifungals is very effective in onychomycosis caused by Aspergillus sp. Scopulariopsis brevicaulis and Fusarium sp. infection are difficult to eradicate and treatment with systemic antifungals should always be associated with topical treatment with nail lacquers. Candida onychomycosis is always a sign of immunodepression. Systemic treatment with itraconazole or fluconazole is usually effective, but relapses are very common.
Journal of The European Academy of Dermatology and Venereology | 2002
Bianca Maria Piraccini; Sandra Lorenzi; Antonella Tosti
To the Editor A 59-year-old man was referred to our out-patient clinic for nail disorders because of a diffuse white discoloration on the nail of his right big toe; the white mark had appeared 1 year before, after nail shedding due to trauma. The affected nail showed several opaque and yellow-whitish areas especially evident on the lateral sides and proximal edge. The nail plate was opaque and fragile with loss of superficial keratin in several zones (fig. 1). Proximal nail plate involvement progressed proximally underneath the proximal nail fold, and the yellow-white discoloration was visible through the overlying transparent cuticle. Gentle scraping of the nail surface with a curette revealed that nail fragility involved even the depths of the nail plate. KOH preparation was positive and cultures grew Aspergillus candidus (fig. 2) on all inocula in three successive nail samplings. A diagnosis of white superficial onychomycosis (WSO) due to Aspergillus candidus was made and we prescribed topical amorolfine nail laquer to be applied twice a week. Cure of the onychomycosis was observed after 6 months of treatment. WSO is usually caused by dermatophytes, particularly Trichophyton interdigitale. 1 According to Zaias 2 5% of WSO are due to nondermatophytic molds, especially of the genus Acremonium , Fusarium and Aspergillus . Candida sp. may sometimes be responsible. 3 In our experience, WSO due to non-dermatophytes is not frequent, and in addition to the case reported here we have seen three other cases of WSO due to Fusarium sp., all with similar clinical features, consisting of ‘deep’ nail plate invasion and diffuse involvement of the nail plate surface. Differential diagnosis with proximal subungual onychomycosis (PSO) is particularly important, since this pattern of nail invasion is frequently shown by molds. 4 In PSO, however, nail penetration starts from the matrix and the superficial nail plate is normal. 1 Superficial speading of PSO is rare in children, but it may occur because the nail plate is very thin in the first years of life. WSO with deep nail penetration seems therefore typical for non-dermatophytic molds. A possible explanation for this ‘deep’ WSO caused by molds of the genus Fusarium and Aspergillus could be the eroding bodies possessed by these fungi. 5 These organs, characteristic of the saprophytic state of fungi, facilitate penetration of the nail plate that would otherwise be a strong barrier against fungal invasion. Although diffuse and deep invasion of the superficial nail could be an important factor in limiting the success of topical treatment, application of topical amorolfine was successful in our patient.
Journal of Dermatological Treatment | 2003
Sandra Lorenzi; Antonietta D'Antuono; Matilde Iorizzo; Antonella Tosti
Ganciclovir is a nucleotide‐analogue similar to acyclovir, which has an in vitro activity against herpes simplex type 1, herpes simplex type 2 and varicella zoster virus. Numerous studies suggest that ganciclovir has clinical efficacy against cytomegalovirus disease, as well as an in vivo antiviral effect, and that this agent reduces morbidity of serious cytomegalovirus infections in immunocompromised patients. Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.
Contact Dermatitis | 1996
Fabrizio Placucci; Sandra Lorenzi; Michelangelo La Placa; Colombina Vincenzi
Case Report A 44-year-old man presented with a !-year history of erythematous desquamative lesions on the penis and scrotum. Erythematous desquamative lesions were also found to be present in the periorbital region and on the frontal area of the hairline. Patch tests with the GIRDCA standard series demonstrated a positive reaction to benzocaine 5% pet. (D2+/D3++). Reviewing the history revealed that the patient habitually used retarding condoms, and that the dermatitis worsened after sexual intercourse. Further patch tests with a rubber series, a piece (1 em X I em) of the same brand of condom that the patient used, a piece (I em X I em) of the same condom washed clean of lubricant, and pure polyethylene glycol and pure glycerin, other components of the lubricant, were positive only to the lubricated condom (D2I D3++).
International Journal of Dermatology | 2011
Fernanda Torres; Antonella Tosti; Cosimo Misciali; Sandra Lorenzi
Background Sarcoidosis is an idiopathic systemic granulomatous disease, in which non‐caseating granulomas formations can occur in any organ. Although rare, involvement of the scalp can occur, which might lead to cicatricial alopecia. Dermoscopic features of scalp sarcoidosis had not been reported.
Journal of Dermatological Treatment | 2000
Bianca Maria Piraccini; Colombina Vincenzi; Sandra Lorenzi; Matilde Jorizzo; Antonella Tosti
A 20-year-old girl presented with a rapidly enlarging band of linear scleroderma involving the forehead and frontal scalp with linear alopecia. The parietal skull contained an arciform bone depression with mild thinning of the hair. Previous treatment with hydroxychloroquine and systemic steroids had failed to arrest the progression of the plaque. Treatment with calcitriol (Rocaltrol®, Roche) 0.75 m g/day for 12 months produced a prompt resolution of the perilesional erythema, gradual thinning of the band of scleroderma and partial hair regrowth. ( J Dermatol Treat (2000) 11: 207-208)
Skin Appendage Disorders | 2018
Maria Mariano; Maria Pia De Padova; Sandra Lorenzi; Norma Cameli
Purpose of the Study: The aim of the present prospective multicenter open study was to clinically and instrumentally evaluate the efficacy, safety, and tolerability of a shampoo, Mellis Cap® shampoo, containing ichthyol, zanthalene, mandelic acid, and honeydew honey in the treatment of mild to moderate scalp psoriasis. Procedures: Thirty subjects with mild to moderate psoriasis applied the shampoo three times a week for 12 weeks. The outcome was evaluated at 30 days (T1), 60 days (T2), and 90 days (T3) of treatment, comparing it to baseline (T0) by means of clinical and patients’ evaluation, digital photographs, and videodermoscopy. Results: Clinical and patients’ evaluation showed improvement of scalp psoriasis and itching. This was confirmed by videodermoscopy analysis with a significant reduction of scalp psoriasis severity at T2 and T3 compared to baseline. No side effects were observed or reported. Conclusions: Study treatment was well tolerated and showed significant clinical and instrumental improvement of scalp psoriasis. Mellis Cap® shampoo is a good alternative to other medicated shampoos in the treatment of mild to moderate scalp psoriasis.
Contact Dermatitis | 2018
Martina Lambertini; Colombina Vincenzi; Sandra Lorenzi; Bm Piraccini; M. La Placa
A 51-year-old woman consulted because of suspected allergic contact dermatitis, recurring over the last 17 years. The patient had been working in an abrasive fibre production factory for the last 20 years, pasting abrasive fibres onto rollers with industrial glues (Fig. 1a). Patch tests performed in 2000 showed positive reactions to nickel and ammoniated mercury, but, on subsequent testing in 2014, both gave negative results. The patient’s medical history was otherwise unremarkable. On clinical